APIXABAN

(a PIX a ban) Brand: Eliquis

What is the most significant information I must know about apixaban?

• Because apixaban keeps your blood from coagulating (clotting) to prevent unwanted blood clots, this medication can also create it easier for you to bleed, even from a minor injury such as a fall or a bump on the head. Avoid activities that may magnify your risk of bleeding or injury. Contact your doctor or search abnormal medical attention if you have bleeding that will not stop.

• Call your doctor at once if you have any signs of bleeding such as weakness, feeling like you might pass out, light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin, pink or brown urine, bloody or tarry stools, coughing up blood, joint pain or swelling, or hard menstrual bleeding.

• Speak any doctor or dentist who treats you that you are using apixaban. If you need surgery or dental work, you may need to stop using the medication for a short time.

• Some drugs can raise or lower your blood levels of apixaban, which may reason side effects or create apixaban smaller effective. Much another drugs (including some over-the-counter medicines) can magnify your risk of bleeding or life-threatening blood clots. It is very significant to speak your doctor about all medicines you have recently used.

• Do not stop taking apixaban without first talking to your doctor. Stopping suddenly can magnify your risk of blood clot or stroke.

What is apixaban?

• Apixaban keeps the platelets in your blood from coagulating (clotting).

• Apixaban is used in people with atrial fibrillation (a heart rhythm disorder) to lower the risk of stroke caused by a blood clot.

• Apixaban may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking apixaban?

• You must not take apixaban if you are allergic to it, if you have an artificial heart valve, or if you have any active bleeding from a surgery, injury, or another cause.

• Apixaban may reason you to bleed more easily, especially if you have a bleeding mess that is inherited or caused by disease.

• To create certain apixaban is safety for you, speak your doctor if you have:

· kidney disease;

· liver malady;

· if you are older than 80; or

· if you weigh smaller than 132 pounds.

• FDA pregnancy category B. Apixaban is not expected to reason birth defects. However, taking this medication during pregnancy may magnify the risk of bleeding while you are pregnant or during your delivery. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether apixaban passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.

How must I take apixaban?

• Apixaban is generally taken twice for day. Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• You may take apixaban with or without food.

• Because apixaban keeps your blood from coagulating (clotting) to prevent unwanted blood clots, this medication can also create it easier for you to bleed, even from a minor injury such as a fall or a bump on the head. Contact your doctor or search abnormal medical attention if you fall or hit your head, or have any bleeding that will not stop.

• If you need surgery or dental work, speak the doctor or dentist onward of time if you have taken apixaban within the past 24 hours. You may need to stop taking apixaban for a short time till you have surgery or another medical procedures.

• Do not stop taking this medicine without first talking to your doctor. Stopping suddenly can magnify your risk of blood clot or stroke.

• If you stop taking apixaban for any cause, your doctor may prescribe other medicine to prevent blood clots before you start taking apixaban again.

• Use apixaban regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Take your following doze the next day and remain on your once-daily schedule. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking apixaban?

• Avoid activities that may magnify your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

What are the possible side effects of apixaban?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have:

· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), bleeding from wounds or needle injections, any bleeding that will not stop;

· hard menstrual periods;

· headache, dizziness, weakness, feeling like you might pass out;

· red, pink, or brown urine;

· black or bloody stools, coughing up blood or vomit that looks like coffee grounds;

· numbness, tingling, or muscle weakness (especially in your legs and feet); or

· loss of movement in any part of your body.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect apixaban?

• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with apixaban, especially:

· bosentan;

· conivaptan;

· cyclosporine;

· imatinib;

· isoniazid, rifabutin, rifampin, rifapentine;

· nefazodone;

· St. John's wort;

· an antibiotic--azithromycin, clarithromycin, erythromycin, nafcillin, telithromycin;

· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

· heart or blood pressure medication--amiodarone, captopril, carvedilol, diltiazem, dronedarone, felodipine, nicardipine, quinidine, ranolazine, verapamil;

· the hepatitis C medications boceprevir or telaprevir;

· HIV or AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir, tipranavir; or

· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone.

• Much another drugs (including some over-the-counter medicines) can magnify your risk of bleeding, or your risk of developing blood clots near the brain or spinal cord during a spinal tap or epidural. It is very significant to speak your doctor about all medicines you have recently used, especially:

· dextran;

· abciximab, eptifibatide, ticagrelor, tirofiban;

· alteplase, reteplase, tenecteplase, urokinase;

· anagrelide, cilostazol, clopidogrel, dipyridamole, eltrombopag, oprelvekin, prasugrel, romiplostim, ticagrelor, ticlopidine;

· argatroban, bivalirudin, dabigatran, lepirudin, rivaroxaban;

· dalteparin, enoxaparin, fondaparinux, heparin, tinzaparin, warfarin, Coumadin;

· an antidepressant such as citalopram, duloxetine, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, venlafaxine, vilazodone;

· an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others; or

· salicylates such as aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others.

• These lists are not complete and much another medicines can interact with apixaban. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about apixaban.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.