INDOMETHACIN

(in doe METH a sin) Brand: Indocin, Indocin SR

What is the most significant information I must know about indomethacin?

• This medication can magnify your risk of life-threatening heart or circulation problems, including heart onslaught or stroke. This risk will magnify the longer you use indomethacin. Do not use this medication just till or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

• Search abnormal medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

• This medication can also magnify your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking indomethacin. Older adults may have an even greater risk of these serious gastrointestinal side effects.

• Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

• Do not drink alcohol while taking indomethacin. Alcohol can magnify the risk of stomach bleeding caused by indomethacin.

• Do not use any another over-the-counter cool, allergy, or pain medicine without first asking your doctor or pharmacist. Much medicines accessible over the counter contain aspirin or another medicines similar to indomethacin (such as ibuprofen, ketoprofen, or naproxen). If you take determined commodity together you may accidentally take too many of this type of medicine. Read the label of any another medication you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.

What is indomethacin?

• Indomethacin is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Indomethacin works by reducing hormones that reason inflammation and pain in the body.

• Indomethacin is used to treat pain or inflammation caused by much conditions such as arthritis, gout, ankylosing spondylitis, bursitis, or tendinitis.

• Indomethacin may also be used for another purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking indomethacin?

• Taking an NSAID can magnify your risk of life-threatening heart or circulation problems, including heart onslaught or stroke. This risk will magnify the longer you use an NSAID. Do not use this medication just till or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

• NSAIDs can also magnify your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

• Do not use this medicine if you are allergic to indomethacin, or if you have a history of allergic reaction to aspirin or another NSAIDs.

• Till taking indomethacin speak your doctor if you are allergic to any drugs, or if you have:

· a history of heart onslaught, stroke, or blood clot;

· heart malady, congestive heart failure, tall blood pressure;

· a history of stomach ulcers or bleeding;

· liver or kidney disease,

· a seizure mess such as epilepsy;

· asthma;

· polyps in your nose;

· a bleeding or blood clotting mess; or

· if you smoke.

• If you have any of these conditions, you may need a doze adjustment or particular trials to safely take indomethacin.

• FDA pregnancy category C. This medicine may be deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment. Taking indomethacin during the recent 3 months of pregnancy may harm the unborn baby. Do not take indomethacin during pregnancy unless your doctor has told you to.

• Indomethacin passes into breast milk and may affect a nursing child. Do not take indomethacin without first talking to your doctor if you are breast-feeding a baby.

• Do not give this medication to a baby younger than 14 years old without the advice of a doctor.

How must I take indomethacin?

• Take this medicine exactly as it was predesigned for you. Do not take the medicine in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

• Take indomethacin with food or milk to lessen stomach upset.

• Do not crush, chew, interrupt, or open an extended-release capsule. Swallow the pill intact. It is specially made to release medication slowly in the body. Breaking or opening the pill would reason too many of the drug to be released at one time.

• Shake the oral suspension (liquid) well just till you measure a doze. To be certain you get the correct doze, measure the liquid with a marked measuring spoon or medication cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• If you take indomethacin for a long period of time, your doctor may want to check you on a regular basis to create certain this medicine is not causing deleterious effects. Do not miss any scheduled visits to your doctor.

• This medicine can reason you to have unusual results with determined medical trials. Speak any doctor who treats you that you are using indomethacin.

• Store indomethacin at room temperature away from moisture and heat. Do not let the liquid medication to freeze.

What happens if I miss a dose?

• If you are taking indomethacin on a regular schedule, take the missed doze as soon as you remember. However, if it is nearly time for the following doze, skip the missed doze and take only the following regularly scheduled doze. Do not take a double dose.

• If you are taking indomethacin as needed, take the missed doze if it is needed, then wait the recommended or predesigned amount of time till taking other dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medication. Symptoms of an indomethacin overdose may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma.

What must I avoid while taking indomethacin?

• Do not drink alcohol while taking indomethacin. Alcohol can magnify the risk of stomach bleeding caused by indomethacin.

• Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Indomethacin can create your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you should be out in the sun.

What are the possible side effects of indomethacin?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking indomethacin and search medical attention or call your doctor at once if you have any of these serious side effects:

· chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;

· black, bloody, or tarry stools;

· coughing up blood or vomit that looks like coffee grounds;

· swelling or rapid weight gain;

· urinating smaller than normal or not at all;

· nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or

· bruising, severe tingling, numbness, pain, muscle weakness.

• Smaller serious side effects may include:

· upset stomach, mild heartburn, diarrhea, constipation;

· bloating, gas;

· dizziness, nervousness, headache;

· skin rash, itching;

· blurred vision; or

· ringing in your ears.

• This is not a complete list of side effects and others may occur. Speak your doctor about any unusual or bothersome side effect. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect indomethacin?

• Speak your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with indomethacin may reason you to bruise or bleed easily.

• Till taking indomethacin, speak your doctor if you are taking any of the next drugs:

· a blood thinner such as warfarin (Coumadin);

· cyclosporine (Gengraf, Neoral, Sandimmune);

· digoxin (digitalis, Lanoxin);

· diuretics (water pills) such as furosemide (Lasix);

· lithium (Eskalith, Lithobid);

· methotrexate (Rheumatrex, Trexall);

· probenecid (Benemid);

· steroids (prednisone and others);

· aspirin or another NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others; or

· a beta-blocker such as atenolol (Tenormin), bisoprolol (Zebeta), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others.

• This list is not complete and there may be another drugs that can interact with indomethacin. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about indomethacin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(32)