ISONIAZID

(eye so NYE a zid) Brand:

What is the most significant information I must know about isoniazid?

• Take all of the isoniazid that has been predesigned for you even if you begin to feel better. Your symptoms may begin to improve till the infection is completely treated.

• Avoid alcohol while taking isoniazid. Alcohol may magnify the risk of hurt to the liver during isoniazid treatment.

• Contact your doctor immediately if you experience numbness or tingling in the hands or foots, weakness, fatigue, loss of appetite, nausea and vomiting, yellowing of the skin or eyes, or darkening of the urine.

What is isoniazid?

• Isoniazid is an antibiotic. It prevents tuberculous bacteria from multiplying in the body.

• Isoniazid is used to treat and to prevent tuberculosis (TB).

• Isoniazid may also be used for purposes another than those listed in this medicine guide.

What must I discuss with my healthcare provider till taking isoniazid?

• Till taking this medicine, speak your doctor if you have

· ever had an allergic reaction to isoniazid,

· kidney malady, or

· liver disease.

• You may not be able to take isoniazid, or you may require a dosage adjustment or particular monitoring during treatment if you have any of the conditions listed above.

• It is not known whether isoniazid will be deleterious to an unborn child. Do not take this medicine without first talking to your doctor if you are pregnant or could become pregnant during treatment.

• It is not known whether isoniazid will be deleterious to a nursing child. Do not take this medicine without first talking to your doctor if you are breast-feeding a baby.

How must I take isoniazid?

• Take isoniazid exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

• Take every doze with a full glass (8 ounces) of water.

• Take isoniazid on an empty stomach 1 hour till or 2 hours after meals.

• If nausea occurs, ask your doctor if you can take isoniazid with food.

• Take all of the isoniazid that has been predesigned for you even if you begin to feel better. Your symptoms may begin to improve till the infection is completely treated.

• It is significant to take isoniazid regularly to get the most benefit.

• Your doctor may also want you to take a supplemental vitamin B6 (pyridoxine) tablet daily during treatment to prevent numbness and tingling caused by low levels of this vitamin.

• Your doctor may want you to have blood trials or another medical evaluations during treatment with isoniazid to monitor progress and side effects.

• Store this medicine at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. If it is nearly time for the following regularly scheduled doze, skip the missed doze and take the following one as directed. Do not take a double doze of this medication.

What happens if I overdose?

• Search abnormal medical attention if an overdose is suspected.

• Symptoms of an isoniazid overdose include nausea, vomiting, dizziness, slurring of speech, blurred vision, visual hallucinations, seizures, coma, and death.

What must I avoid while taking isoniazid?

• Avoid alcohol while taking isoniazid. Alcohol will magnify the risk of hurt to the liver during treatment with this medication.

• Use caution with the foods listed adown. They can interact with isoniazid and reason a reaction that includes a severe headache, big pupils, neck stiffness, nausea, vomiting, diarrhea, flushing, sweating, itching, irregular heartbeats, and chest pain. A reaction will not necessarily occur, but ate these foods with caution before you know if you will react to them. Call your doctor immediately if you experience any of these symptoms.

• Ate the next foods with caution:

· cheeses, including American, Blue, Boursault, Brick, Brie, Camembert, Cheddar, Emmenthaler, Gruyere, Mozzarella, Parmesan, Romano, Roquefort, Stilton, and Swiss;

· sour cream and yogurt;

· beef or chicken liver, fish, meats prepared with tenderizer, bologna, pepperoni, salami, summer sausage, game meat, meat extracts, caviar, dried fish, herring, shrimp paste, and tuna;

· avocados, bananas, figs, raisins, and sauerkraut;

· soy sauce, miso soup, bean curd, and fava beans;

· yeast extracts;

· ginseng;

· chocolate;

· caffeine (coffee, tea, cola, etc.); and

· beer (alcoholic and nonalcoholic), red wine (especially Chianti), sherry, vermouth, and another distilled spirits.

What are the possible side effects of isoniazid?

• If you experience any of the next serious side effects, stop taking isoniazid and search abnormal medical attention or contact your doctor immediately:

· an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or person; or hives);

· unusual weakness or fatigue;

· nausea, vomiting, or loss of appetite;

· abdominal pain;

· yellow skin or eyes;

· dark urine;

· numbness or tingling in your hands or feet;

· seizures;

· blurred vision; or

· confusion or emergency behavior.

• Side effects another than those listed here may also occur. Conversation to your doctor about any side effect that seems unusual or that is especially bothersome. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect isoniazid?

• Till taking isoniazid, speak your doctor if you are taking any of the next drugs:

· antacids. Aluminum salts will decrease the action of isoniazid. Do not take antacids that contain aluminum for 1 to 2 full hours till or after taking a doze of isoniazid.

· ketoconazole (Nizoral) and itraconazole (Sporanox). Isoniazid may decrease the actions of these antifungal medicines. Therefore, a fungal infection may not be adequately treated.

· rifampin (Rimactane, Rifadin) or rifabutin (Mycobutin).

· disulfiram (Antabuse). Unusual behavior and coordination difficulties may occur if these medicines are taken together.

• Isoniazid may magnify the effects of the next medicines:

· warfarin (Coumadin);

· carbamazepine (Tegretol);

· cycloserine (Seromycin);

· phenytoin (Dilantin), ethotoin (Peganone), and mephenytoin (Mesantoin);

· meperidine (Demerol);

· benzodiazepines such as alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril);

· theophylline (Theo-Dur, Theochron, Theolair, Elixophyllin, Slo-Phyllin, others);

· ethionamide (Trecator-SC).

• You may require a dosage adjustment or particular monitoring if you are taking any of the medicines listed above.

• Drugs another than those listed here may also interact with isoniazid. Conversation to your doctor and pharmacist till taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has additional information about isoniazid written for health professionals that you may read.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.