RIVAROXABAN

(RIV a ROX a ban) Brand: Xarelto

What is the most significant information I must know about rivaroxaban?

• You must not use this medicine if you are allergic to rivaroxaban, or if you have active or uncontrolled bleeding.

• Speak any doctor who treats you that you are using rivaroxaban. If you need anesthesia for a medical procedure or surgery, you may need to stop using the medication for a short time.

• Rivaroxaban can reason a very serious blood clot near your brain or spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural), especially if you have a genetic spinal defect, a history of spinal surgery or repeated spinal taps, or if you are using another medications to treat or prevent blood clots. Symptoms of this type of blood clot include numbness, tingling, muscle weakness, or loss of movement.

• Blood clots near the brain or spinal cord may occur during a spinal tap or epidural if you are using rivaroxaban with another drugs that can affect blood clotting, including aspirin, non-steroidal anti-inflammatory drugs (NSAIDs) such as Advil or Motrin, and any another medications to treat or prevent blood clots.

• Much another drugs (including some over-the-counter medicines) can magnify your risk of bleeding or life-threatening blood clots, and it is very significant to speak your doctor about all medicines you have recently used.

• Speak your caregivers at once if you have signs of bleeding such as black or bloody stools, coughing up blood, confusion, feeling like you might pass out, or any bleeding that will not stop.

• Do not stop taking this medicine without first talking to your doctor. Stopping suddenly can magnify your risk of blood clot or stroke.

What is rivaroxaban?

• Rivaroxaban is an anticoagulant (blood thinner) that prevents the formation of blood clots.

• Rivaroxaban is used to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after determined types of surgery.

• Rivaroxaban is also used in people with atrial fibrillation (a heart rhythm disorder) to lower the risk of stroke caused by a blood clot.

• Rivaroxaban may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking rivaroxaban?

• You must not use this medicine if you are allergic to rivaroxaban, or if you have active or uncontrolled bleeding.

• Rivaroxaban can reason a very serious blood clot near your brain or spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could reason long-term paralysis, and may be more likely to occur if you have:

· a genetic spinal defect;

· a history of spinal surgery or repeated spinal taps; or

· if you are using another medications to treat or prevent blood clots.

• Rivaroxaban may reason you to bleed more easily, especially if you have:

· a bleeding mess that is inherited or caused by disease;

· hemorrhagic stroke;

· uncontrolled tall blood pressure; or

· stomach or intestinal bleeding or ulcer.

• To create certain you can safely take rivaroxaban, speak your doctor if you have kidney or liver disease.

• FDA pregnancy category C. It is not known whether rivaroxaban will harm an unborn child. However, this medication could reason bleeding complications during childbirth. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether rivaroxaban passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using rivaroxaban.

How must I take rivaroxaban?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Rivaroxaban is generally taken once for day. Follow your doctor's instructions.

• For hip or knee replacement surgery: You may take rivaroxaban with or without food.

• For atrial fibrillation: Take rivaroxaban with your evening meal.

• Speak any doctor who treats you that you are using rivaroxaban. If you need surgery or dental work, speak the surgeon or dentist onward of time that you are using this medicine. If you need anesthesia for a medical procedure or surgery, you may need to stop using rivaroxaban for a short time.

• Use rivaroxaban regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.

• Do not stop taking this medicine without first talking to your doctor. Stopping suddenly can magnify your risk of blood clot or stroke.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Take your following doze the next day and remain on your once-daily schedule. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose may reason overweening bleeding.

What must I avoid while taking rivaroxaban?

• Avoid activities that may magnify your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

What are the possible side effects of rivaroxaban?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using rivaroxaban and call your doctor at once if you have a serious side effect such as:

· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), bleeding from wounds or needle injections, any bleeding that will not stop;

· hard menstrual periods;

· headache, dizziness, weakness, feeling like you might pass out;

· red or pink urine;

· black or bloody stools, coughing up blood or vomit that looks like coffee grounds;

· numbness, tingling, or muscle weakness (especially in your legs and feet); or

· loss of movement in any part of your body.

• Smaller serious side effects may include:

· muscle pain;

· itching; or

· pain in your arms or legs.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect rivaroxaban?

• Speak your doctor about all another medicines you use, especially:

· bosentan (Tracleer);

· conivaptan (Vaprisol);

· dexamethasone (Cortastat, Dexasone, Solurex, DexPak);

· rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);

· St. John's wort;

· quinidine (Quin-G);

· verapamil (Calan, Covera, Isoptin, Verelan);

· an antibiotic such as azithromycin (Zithromax), clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole);

· antifungal medicine such as itraconazole (Sporanox) or ketoconazole (Nizoral);

· a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

· heart or blood pressure medicine such as reserpine, amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), dronedarone (Multaq), felodipine (Plendil), quinidine (Quin-G), or verapamil (Calan, Covera, Isoptin, Verelan);

· HIV medicine such as efavirenz (Sustiva, Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), or saquinavir (Invirase);

· medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil);

· medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune) or tacrolimus (Prograf); or

· seizure medicine such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

• Much another drugs (including some over-the-counter medicines) can magnify your risk of bleeding, or your risk of developing blood clots near the brain or spinal cord during a spinal tap or epidural. It is very significant to speak your doctor about all medicines you have recently used, especially:

· dextran (Gentran, Hyskon);

· abciximab (ReoPro), eptifibatide (Integrilin), ticagrelor (Brilinta), tirofiban (Aggrastat);

· alteplase (Activase), reteplase (Retavase), tenecteplase (TNKase), urokinase (Abbokinase);

· anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eltrombopag (Promacta), oprelvekin (Neumega), prasugrel (Effient), romiplostim (Nplate), ticagrelor (Brilinta), ticlopidine (Ticlid);

· argatroban (Acova), bivalirudin (Angiomax), dabigatran (Pradaxa), lepirudin (Refludan);

· dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), heparin, tinzaparin (Innohep), warfarin (Coumadin, Jantoven);

· an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or

· salicylates such as aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others.

• This list is not complete and another drugs may interact with rivaroxaban. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about rivaroxaban.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

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