VORICONAZOLE

(vor i KON a zole) Brand: VFEND

What is the most significant information I must know about voriconazole?

• Do not use voriconazole if you are pregnant. It could harm the unborn child.

• There are much another medicines that can reason serious or life-threatening drug interactions with voriconazole. Tell your doctor about all the prescription and over-the-counter medications you use.

• Till taking voriconazole, speak your doctor if you have heart rhythm problems, an electrolyte imbalance, liver or kidney malady, or a history of allergy to another antifungal medications such as fluconazole (Diflucan), ketoconazole (Nizoral), or itraconazole (Sporanox).

• Take this medicine for the full predesigned length of time. Your symptoms may improve till the infection is completely cleared. Skipping doses may also magnify your risk of further infection that is resistant to antibiotics. Voriconazole will not treat a viral infection such as the general cool or flu.

• Voriconazole can reason problems with your vision. If you use this medication for more than 28 days, you may need to have your eyes checked.

What is voriconazole?

• Voriconazole is an antifungal medication.

• Voriconazole is used to treat infections caused by yeast or another types of fungus.

• Voriconazole may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking voriconazole?

• You must not take this medicine if you are allergic to voriconazole, or if you are taking any of the next drugs:

· carbamazepine (Carbatrol, Equetro, Tegretol);

· cisapride (Propulsid);

· pimozide (Orap);

· quinidine (Quin-G);

· sirolimus (Rapamune);

· mephobarbital (Mebaral) or phenobarbital (Solfoton);

· ritonavir (Norvir, Kaletra) in tall doses;

· rifabutin (Mycobutin) or rifampin (Rifadin, Rimactane, Rifater);

· St. John's wort; or

· an ergot medication such as ergotamine (Ergomar, Cafergot, Ercaf, Wigraine, others) or dihydroergotamine (D.H.E., Migranal).

• The drugs listed above can reason dangerous serious or life-threatening drug interactions with voriconazole. Speak your doctor about all another medicines you are using.

• To create certain you can safely take voriconazole, speak your doctor if you have any of these another conditions:

· heart rhythm problems;

· a metabolic mess such as tall or low levels of calcium, potassium, or magnesium;

· liver disease;

· kidney malady; or

· a history of allergy to another antifungal medications such as fluconazole (Diflucan), ketoconazole (Nizoral), or itraconazole (Sporanox).

• Voriconazole tablets contain lactose. Till taking a voriconazole tablet, speak your doctor if you have a hereditary form of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.

• FDA pregnancy category D. Do not use voriconazole if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.

• It is not known if voriconazole passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take voriconazole?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Take voriconazole at least one hour till or after eating a meal.

• Shake the oral suspension (liquid) well just till you measure a doze. Measure the liquid with a particular dose-measuring spoon or medication cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• Do not mix the oral suspension with any another medication or liquid.

• To be certain voriconazole is helping your condition, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Visit your doctor regularly.

• Voriconazole can reason problems with your vision. If you use this medication for more than 28 days, you may need to have your eyes checked.

• Store voriconazole tablets at room temperature away from moisture and heat. Store the oral liquid at room temperature for up to 14 days. Throw away any unused liquid after 14 days.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include vision problems, overweening mouth watering, enlarged pupils, weakness, loss of balance, shortness of breath, or seizure (convulsions).

What must I avoid while taking voriconazole?

• Voriconazole may reason changes in vision including blurred vision and sensitivity to easy. Wear sunglasses during the day to protect your eyes from bright easy. Be careful if you drive or do anything that requires you to have clear vision.

• Avoid exposure to sunlight or tanning beds. Voriconazole can create you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of voriconazole?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have any of these serious side effects:

· sudden behavior changes, problems with thinking or speech;

· upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· urinating smaller than normal or not at all;

· bone pain, swelling;

· uneven heart course, chest pain, common ill feeling; or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• Smaller serious side effects may include:

· vision problems such as blurred vision, eyes being more sensitive to light;

· fever;

· mild nausea, vomiting, or diarrhea;

· headache; or

· swelling in your hands, ankles, or feet.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect voriconazole?

• Much drugs can interact with voriconazole. Adown is just a partial list. Speak your doctor if you are using:

· clopidogrel (Plavix);

· cyclosporine (Sandimmune, Neoral);

· phenytoin (Dilantin);

· prednisolone (Orapred, Pediapred, Predalone, Veripred, and others);

· tacrolimus (Prograf);

· warfarin (Coumadin, Jantoven);

· birth control pills;

· medicine to treat HIV or AIDS, especially efavirenz (Atripla, Sustiva);

· alfentanil (Alfenta) or fentanyl (Abstral, Actiq, Fentora, Duragesic, Lazanda, Onsolis);

· omeprazole (Prilosec) and another stomach acid reducers;

· cancer medication such as vinblastine (Velban), vincristine (Oncovin), or vinorelbine (Navelbine);

· methadone (Diskets, Methadose, Dolophine) or oxycodone (OxyContin, Combunox, Roxicodone, Percocet);

· non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

· tranquilizers or sedatives such as alprazolam (Xanax), midazolam (Versed), triazolam (Halcion), and others;

· cholesterol-lowering medicines such as atorvastatin (Lipitor, Caduet), lovastatin (Mevacor), pravastatin (Pravachol), or simvastatin (Zocor, Simcor, Vytorin);

· heart or blood pressure medication such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), felodipine (Plendil), nicardipine (Cardene), nifedipine (Nifedical, Procardia), and others; or

· an oral diabetes medication such as glipizide (Glucotrol, Metaglip), glyburide (DiaBeta, Micronase, Glucovance), or tolbutamide (Orinase).

• This list is not complete and there are much another drugs that can interact with voriconazole. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about voriconazole.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(47)