PAROXETINE

(pa ROX a teen) Brand: Paxil, Paxil CR, Pexeva

What is the most significant information I must know about paroxetine?

• You must not use paroxetine if you are also taking pimozide or thioridazine, or if you are being treated with methylene blue injection.

• Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using paroxetine. Your family or another caregivers must also be alert to changes in your mood or symptoms.

• Do not give paroxetine to anyone younger than 18 years old without the advice of a doctor. Paroxetine is not authorized for treating depression in children.

What is paroxetine?

• Paroxetine is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may become unbalanced.

• Paroxetine is used to treat depression, obsessive-compulsive mess, anxiety disorders, post-traumatic stress mess (PTSD), and premenstrual dysphoric mess (PMDD).

• Paroxetine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking paroxetine?

• You must not use this medication if you are allergic to paroxetine, or if:

· you are also taking pimozide or thioridazine; or

· you are being treated with methylene blue injection.

• Do not use paroxetine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking paroxetine you should wait at least 14 days till you start taking an MAO inhibitor.

• To create certain paroxetine is safety for you, speak your doctor if you have:

· liver or kidney disease;

· a bleeding or blood clotting disorder;

· seizures or epilepsy;

· narrrow-angle glaucoma; or

· bipolar mess (manic depression), or a history of drug abuse or suicidal thoughts.

• FDA pregnancy category D. Taking an SSRI antidepressant during pregnancy may reason heart defects, serious lung problems, or another complications in the child. However, you may have withdrawal symptoms or a relapse of depression if you stop taking your antidepressant. Speak your doctor right away if you become pregnant while taking paroxetine. Do not start or stop taking this medication during pregnancy without your doctor's advice.

• Paroxetine can pass into breast milk and may harm a nursing child. Speak your doctor if you are breast-feeding a baby.

• Do not give paroxetine to anyone younger than 18 years old without the advice of a doctor. Paroxetine is not authorized for treating depression in children.

How must I take paroxetine?

• Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact.

• Shake the oral suspension (liquid) well just till you measure a doze. Measure the liquid with a particular dose-measuring spoon or medication cup. If you do not have a dose-measuring device, ask your pharmacist for one.

• It may take up to 4 weeks till your symptoms improve. Hold using the medicine as directed and speak your doctor if your symptoms do not improve.

• Do not stop using paroxetine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using paroxetine. Follow your doctor's instructions about tapering your dose.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of paroxetine can be fatal.

What must I avoid while taking paroxetine?

• Ask your doctor till taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with paroxetine may reason you to bruise or bleed easily.

• Drinking alcohol can magnify some of the side effects of paroxetine.

• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of paroxetine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

• Call your doctor at once if you have:

· unusual bone pain or tenderness, swelling or bruising;

· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), coughing up blood;

· agitation, hallucinations, fever, quick heart course, overactive reflexes, nausea, vomiting, diarrhea, feeling unsteady, loss of coordination, fainting;

· very stiff (rigid) muscles, tall fever, sweating, confusion, quick or uneven heartbeats, tremors, overactive reflexes, feeling like you might pass out;

· headache, trouble concentrating, memory problems, weakness, confusion, hallucinations, seizure, shallow breathing or breathing that stops; or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• General side effects may include:

· mild headache, drowsiness, dizziness, sleep problems (insomnia), feeling restless or nervous;

· mild nausea, constipation, weight changes;

· decreased sex drive, impotence, or difficulty having an orgasm; or

· dry mouth, yawning, or ringing in your ears.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect paroxetine?

• Taking paroxetine with another drugs that create you sleepy or slow your breathing can magnify these effects. Ask your doctor till taking paroxetine with a sleeping pill, narcotic pain medication, muscle relaxer, or medication for anxiety or seizures.

• Much drugs can interact with paroxetine. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with paroxetine, especially:

· any another antidepressant;

· cimetidine;

· lithium;

· risperidone;

· St. John's wort;

· tamoxifen;

· theophylline;

· tryptophan (sometimes called L-tryptophan);

· a blood thinner such as warfarin, Coumadin;

· heart medication--digoxin, flecainide, encainide, propafenone;

· migraine headache medicine--sumatriptan, rizatriptan, and others;

· pain medication--fentanyl or tramadol; or

· a phenothiazine--chlorpromazine, haloperidol, promethazine, risperidone, and others.

• This list is not complete and much another drugs can interact with paroxetine. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about paroxetine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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