EPTIFIBATIDE

(ep ti FYE ba tide) Brand: Integrilin

What is the most significant information I must know about eptifibatide?

• You must not receive this medicine if you are allergic to eptifibatide, if you have or will soon receive treatment with similar medications such as abciximab (ReoPro) or tirofiban (Aggrastat).

You must not receive this medicine if you have severe or uncontrolled tall blood pressure, if you are on dialysis due to kidney failure, history of a bleeding or blood clotting mess, if you had a stroke or any type of bleeding within the past 30 days, or if you had any type of surgery, injury, or medical abnormal within the past 6 weeks.

Eptifibatide is not expected to be deleterious to an unborn child. However, aspirin is sometimes given with eptifibatide, and aspirin can reason bleeding when it is taken during the recent 3 months of pregnancy. Aspirin can also reason side effects in a newborn baby.

Tell your doctor if you are pregnant or plan to become pregnant during treatment with eptifibatide and aspirin.

• Because eptifibatide keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also create it easier for you to bleed, even from a minor injury. Contact your doctor or search abnormal medical attention if you have bleeding that will not stop.

What is eptifibatide?

Eptifibatide keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with determined heart or blood vessel conditions.

Eptifibatide is used to prevent blood clots or heart onslaught in people with severe chest pain or another conditions, and in those who are undergoing a procedure called angioplasty (to open blocked arteries).

Eptifibatide may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till receiving eptifibatide?

• You must not receive this medicine if you are allergic to eptifibatide, if you have or will soon receive treatment with similar medications such as abciximab (ReoPro) or tirofiban (Aggrastat), or if you have:

· kidney failure and you are on dialysis;

· severe or uncontrolled tall blood pressure;

· history of a bleeding or blood clotting mess, such as hemophilia or thrombocytopenia;

· if you have had a stroke or any type of bleeding within the past 30 days; or

· if you have had any type of surgery, injury, or medical abnormal within the past 6 weeks.

• To create certain you can safely receive eptifibatide, speak your doctor if you have kidney disease.

• FDA Pregnancy Category B. Eptifibatide is not expected to be deleterious to an unborn child. However, aspirin is sometimes given with eptifibatide, and aspirin can reason bleeding when it is taken during the recent 3 months of pregnancy. Aspirin can also reason side effects in a newborn baby. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether eptifibatide passes into breast milk or if it could harm a nursing child. Do not receive this medicine without telling your doctor if you are breast-feeding a baby.

How is eptifibatide given?

Eptifibatide is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Eptifibatide is sometimes given near the clock for up to 4 days in a row.

• If you are receiving this injection during an angioplasty procedure, the medication will be given throughout the entire procedure and for up to 24 hours after the procedure.

Eptifibatide is sometimes given together with aspirin. Follow your doctor's instructions about how many aspirin to take and for how long.

• To be certain this medication is helping your condition and is not causing deleterious effects, your blood will need to be tested often. Visit your doctor regularly.

• Because eptifibatide keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also create it easier for you to bleed, even from a minor injury. Contact your doctor or search abnormal medical attention if you have bleeding that will not stop.

What happens if I miss a dose?

• Since eptifibatide is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while receiving eptifibatide?

• Avoid activities that may magnify your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

• Avoid drinking alcohol. It may magnify your risk of bleeding in your stomach or intestines.

What are the possible side effects of eptifibatide?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

· blood in your urine;

· black, bloody, or tarry stools;

· coughing up blood or vomit that looks like coffee grounds;

· any bleeding that will not stop;

· sudden numbness or weakness, especially on one side of the body;

· sudden severe headache, confusion, problems with vision, speech, or balance;

· fever, chills, body aches, flu symptoms; or

· feeling like you might pass out.

• Smaller serious side effects may also occur, such as:

· nausea;

· upset stomach; or

· bleeding near the IV needle.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect eptifibatide?

• Speak your doctor about all another medicines you use, especially:

· a blood thinner such as warfarin (Coumadin, Jantoven), heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), fondaparinux (Arixtra), or tinzaparin (Innohep);

· drugs that dissolve blood clots, such as alteplase (Activase), tenecteplase (TNKase), urokinase (Abbokinase);

· medicines that hold blood platelets from clumping together, such as anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), prasugrel (Effient), ticlopidine (Ticlid); or

· medicines that block the action of a blood-clotting enzyme, such as argatroban (Acova), dabigatran (Pradaxa), bivalirudin (Angiomax), lepirudin (Refludan).

• This list is not complete and another drugs may interact with eptifibatide. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist can provide more information about eptifibatide.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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