(URE oh KYE nase) Brand: Abbokinase, Kinlytic
• You must not use this medicine if you are allergic to urokinase, or if you have inside bleeding, a brain tumor or aneurysm, hemophilia or another bleeding mess, arterial hypertension, or if you have had a last stroke, surgery, organ transplant, or medical abnormal .
• Till you receive urokinase, speak your doctor if you have liver or kidney malady, diabetes, heart problems, if you are pregnant or recently gave birth, a history of stroke or stomach bleeding.
• Speak your caregivers at once if you have a serious side effect such as light bruising or bleeding, blood in your stools, coughing up blood, chest pain, sudden problems with vision or speech, swelling, discoloration of your fingers or toes, severe stomach pain, weak or shallow breathing, fever, chills, or flu symptoms.
• Till you receive urokinase, speak your doctor if you are using a blood thinner such as warfarin (Coumadin), aspirin or an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), and others, or any medicine used to prevent blood clots such as Kabikinase, Plavix, Ticlid, Persantine, Streptase, and others.
• Urokinase is a man-made product developed using a protein that occurs naturally in the kidneys. Urokinase is a thrombolytic agent that works by dissolving blood clots.
• Urokinase is used to treat blood clots in the lungs.
• Urokinase may also be used for another purposes not listed in this medicine guide.
• You must not use this medicine if you are allergic to urokinase, or if you have:
· inside bleeding;
· a brain tumor;
· a brain aneurysm (dilated blood vessel);
· a bleeding or blood clotting mess (such as hemophilia);
· a condition called arterial hypertension;
· if you have had a last medical abnormal requiring CPR (cardiopulmonary resuscitation);
· if you have had a stroke, brain surgery, or spinal surgery within in the past 2 months.
• If you have determined conditions, you may need a doze adjustment or particular trials to safely use this medicine. Till you receive urokinase, speak your doctor if you have:
· a history of stroke;
· severe liver or kidney disease;
· eye problems caused by diabetes;
· an infection of the lining of your heart (also called bacterial endocarditis);
· a blood clot of your heart;
· a last history of stomach or intestinal bleeding;
· if you are pregnant or have had a child within the past 10 days; or
· if you have had surgery or an organ transplant within the past 10 days.
• FDA pregnancy category B. Urokinase is not expected to be deleterious to an unborn child. However, your doctor must know if you are pregnant till you receive this medication.
• It is not known whether urokinase passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.
• Urokinase is made from human kidney cells and albumin (part of the blood) and it may contain viruses and another infectious agents that can reason malady. Although donated human blood is screened, tested, and treated to reduce the risk of it containing anything that could reason malady, there is still a little possibility it could transmit malady. Conversation with your doctor about the risks and benefits of using this medication.
• Urokinase is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.
• Urokinase is given slowly, generally over a period of 12 hours, using a continuous infusion pump.
• Your breathing, blood pressure, oxygen levels, and another vital signs will be watched closely while you are receiving urokinase.
• Since urokinase is given by a healthcare professional in a clinical setting, you are not likely to miss a dose.
• Because urokinase is given in a controlled clinical setting, an overdose is not expected to occur.
• Avoid taking aspirin or ibuprofen (Motrin, Advil) to treat a fever shortly after you have received urokinase. These medications can magnify your risk of bleeding. Ask your doctor about another methods of treating a fever.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Speak your caregivers at once if you have a serious side effect such as:
· light bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection );
· bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling;
· sudden headache or problems with speech, vision, or balance;
· fever, chills, flu symptoms, nausea, vomiting, back pain, or stomach pain;
· drowsiness, confusion, mood changes, heighten thirst, loss of appetite;
· swelling, weight gain, feeling short of breath;
· urinating smaller than normal or not at all;
· red or purple discoloration of fingers or toes;
· weak or shallow breathing, blue-colored lips or fingernails;
· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure); or
· pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, quick heart rate).
• This is not a complete list of side effects and others may occur. Speak your doctor about any unusual or bothersome side effect. You may message side effects to FDA at 1-800-FDA-1088.
• The next drugs can interact with urokinase. Speak your doctor if you are using any of these:
· a blood thinner such as warfarin (Coumadin);
· aspirin or an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others; or
· medicine used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), or ticlopidine (Ticlid).
• This list is not complete and there may be another drugs that can interact with urokinase. Speak your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start a new medicine without telling your doctor.
• Your doctor or pharmacist can provide more information about urokinase.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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