CONIVAPTAN

(koe NYE vap tan) Brand: Vaprisol

What is the most significant information I must know about conivaptan?

• You must not receive this medicine if you are allergic to conivaptan or cereal commodity, or if you are unable to urinate.

• Till you receive conivaptan, speak your doctor if you have congestive heart failure, liver malady, kidney malady, alcoholism, or if you are malnourished.

• To be certain this medication is helping your condition, your blood will need to be tested often.

• Speak your caregivers at once if you have a serious side effect such as confusion, extreme thirst, muscle weakness or limp feeling, trouble speaking or swallowing, mood changes, or swelling or discomfort where the IV needle is placed.

There are much another drugs that must not be used together with conivaptan, including determined antibiotics or antifungal medicines, heart or blood pressure medicine, and HIV/AIDS medicine.

Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

What is conivaptan?

Conivaptan reduces the level of a hormone that regulates the balance of water and salt (sodium) in the body. Tall levels of this hormone can reason an imbalance that results in low sodium levels and fluid retention.

Conivaptan is used to treat hyponatremia (low sodium levels). Conivaptan improves urine flow without causing the body to lose too many sodium as you urinate.

Conivaptan may also be used for purposes than those listed in this medicine guide.

What must I discuss with my health care provider till receiving conivaptan?

• You must not receive this medicine if you are allergic to conivaptan or cereal commodity, or if you are unable to urinate.

• You must not use conivaptan if you are using any of the next drugs:

· imatinib (Gleevec);

· isoniazid (for treating tuberculosis);

· an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);

· an antidepressant such as nefazodone;

· antifungal medicine such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);

· heart or blood pressure medicine such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others; or

· HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra).

• To create certain you can safely receive conivaptan, speak your doctor if you have any of these another conditions:

· congestive heart failure;

· liver disease;

· kidney disease;

· alcoholism; or

· if you are malnourished.

• FDA pregnancy category C. It is not known whether conivaptan will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether conivaptan passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are receiving conivaptan.

How is conivaptan given?

Conivaptan is injected into a vein through an IV. You will receive this injection in a hospital setting. Conivaptan is given through an IV line and a needle placed into one of your big veins (such as in your upper chest).

Conivaptan is infused around-the-clock for up to 4 days. This medicine is generally given only in a hospital.

• Because conivaptan can irritate the skin or vein when the medication enters the body, your IV needle will be moved to a various vein each 24 hours.

• To be certain this medication is helping your condition, your blood will need to be tested often.

What happens if I miss a dose?

• Since conivaptan is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include some of the serious side effects listed in this medicine guide.

What must I avoid while receiving conivaptan?

• Follow your doctor's instructions about the type and amount of liquids you must drink. In some cases, drinking too many liquid can be as unsafe as not drinking enough.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What are the possible side effects of conivaptan?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Speak your caregivers at once if you have a serious side effect such as:

· feeling like you might pass out;

· low potassium (confusion, uneven heart course, extreme thirst, heighten urination, leg discomfort, muscle weakness or limp feeling);

· trouble speaking, trouble swallowing, weakness, mood changes, muscle spasm or weakness in your arms and legs, seizure;

· pain, redness, or swelling where the IV needle is placed;

· swelling, rapid weight gain; or

· pain or burning when you urinate.

• Smaller serious side effects may include:

· mild fever;

· headache;

· diarrhea; or

· vomiting.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect conivaptan?

• Much drugs can interact with conivaptan. Adown is just a partial list. Speak your doctor if you are using:

· digoxin (Lanoxin);

· an antibiotic such as doxycycline (Doryx, Oracea, Periostat, Vibramycin), rifampin (Rifater, Rifadin, Rifamate), rifabutin (Mycobutin), tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap), or trimethoprim (Proloprim, Bactrim, Septra, SMX-TMP);

· anti-malaria medication;

· an antidepressant;

· anti-psychotic medication;

· asthma or allergy medicine such as albuterol (Proventil, Ventolin), budesonide (Pulmicort, Rhinocort), fluticasone (Flonase, Flovent), montelukast (Singulair), theophylline (Elixophyllin, Theo-24, Uniphyl);

· a beta-blocker such as bisoprolol (Zebeta, Ziac);

· cancer medication such as bortezomib (Velcade), busulfan, docetaxel (Taxotere), doxorubicin (Adriamycin), exemestane (Aromasin), etoposide (VePesid, Toposar), flutamide (Eulexin), ifosfamide (Ifex), irinotecan (Camptosar), letrozole (Femara), paclitaxel (Taxol), tamoxifen (Soltamox), teniposide (Vumon), vinorelbine (Navelbine), vincristine (Oncovin, Vincasar), vinblastine (Velban);

· cholesterol-lowering drugs such as atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin);

· diabetes medicine such as nateglinide (Starlix), pioglitazone (Actos), repaglinide (Prandin);

· erectile dysfunction medicine;

· ergot medicines such as D.H.E. 45, Ergomar, Cafergot, Ergotrate, Methergine, Migergot, or Migranal;

· heart or blood pressure medications such as amiodarone (Cordarone, Pacerone), amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), disopyramide (Norpace), enalapril (Vasotec), isradipine (Dynacirc), losartan (Cozaar, Hyzaar), nicardipine (Cardene), nimodipine (Nimotop), nisoldipine (Sular), quinidine (Quin-G);

· HIV medicines such as efavirenz (Sustiva, Atripla), nevirapine (Viramune), or tipranavir (Aptivus);

· medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);

· narcotic medications;

· a sedative such as clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), and others;

· seizure medicine; or

· stomach acid reducers such as lansoprazole (Prevacid), ondansetron (Zofran), rabeprazole (AcipHex).

This list is not complete and there are much another drugs that can interact with conivaptan. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your doctor or pharmacist can provide more information about conivaptan.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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