NEFAZODONE

(ne FAZ oh done) Brand:

What is the most significant information I must know about nefazodone?

• Do not take nefazodone together with carbamazepine (Tegretol), cisapride (Propulsid), pimozide (Orap), or an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam).

• There are much another medicines that can interact with nefazodone. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor. Hold a list with you of all the medicines you use and show this list to any doctor or another healthcare provider who treats you.

• You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

• Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

What is nefazodone?

• Nefazodone is an antidepressant. It is used to treat depression, including major depressive disorder.

• Nefazodone is not chemically similar to another groups of antidepressants, such as selective serotonin reuptake inhibitors or "SSRIs", tricyclic antidepressants, or monoamine oxidase inhibitors or "MAOIs."

• Nefazodone may also be used for another purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking nefazodone?

• You must not take this medicine if you are allergic to nefazodone or trazodone (Desyrel), or if you have ever had liver problems caused by taking nefazodone.

• Do not take nefazodone if you are using any of the next drugs:

· carbamazepine (Tegretol);

· cisapride (Propulsid);

· pimozide (Orap); or

· an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam).

• Serious and sometimes fatal reactions can occur when these medicines are taken with nefazodone. You should wait at least 14 days after stopping an MAO inhibitor till you can take nefazodone. You should wait 7 days after stopping nefazodone till you can take an MAOI.

• If you have any of these another conditions, you may need a doze adjustment or particular trials to safely take nefazodone:

· liver malady (especially cirrhosis);

· heart malady or last heart attack;

· bipolar mess (manic depression);

· epilepsy or another seizure mess; or

· a history of suicidal thoughts or actions.

• You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Speak your doctor if you have worsening depression or suicidal thoughts during the first different weeks of treatment, or whenever your doze is changed.

• Your family or another caregivers must also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

• FDA pregnancy category C. It is not known whether nefazodone is deleterious to an unborn child. Till taking this medicine, speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether nefazodone passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take nefazodone?

• Take this medicine exactly as it was predesigned for you. Do not take the medicine in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze to create certain you get the excellent results from the medication.

• You may take nefazodone with or without food.

• If you need to have any type of surgery, speak the surgeon onward of time that you are taking nefazodone. You may need to stop using the medication for a short time.

• It may take different weeks of using this medication till your symptoms improve. For excellent results, hold using the medicine as directed.

• Store nefazodone at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. However, if it is nearly time for the following regularly scheduled doze, skip the missed doze and take the following one as directed. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have taken too many of this medicine. Overdose symptoms may include nausea, vomiting, extreme drowsiness, or seizure (convulsions).

What must I avoid while taking nefazodone?

• Avoid drinking alcohol while you are taking nefazodone.

• Nefazodone can reason side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What are the possible side effects of nefazodone?

• Get abnormal medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking nefazodone and call your doctor at once if you have a serious side effect such as:

· nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· confusion, hallucinations, unusual thoughts or behavior;

· seizure (convulsions);

· penis erection that is painful or lasts 4 hours or longer;

· fever, chills, body aches, flu symptoms; or

· feeling like you might pass out.

• Smaller serious side effects may include:

· mild nausea, diarrhea, constipation;

· dizziness, drowsiness, weakness;

· sleep problems (insomnia);

· dry mouth, sore throat;

· vision problems;

· headache; or

· heighten appetite.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect nefazodone?

• Cool or allergy medication, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures or anxiety may add to the side effects of nefazodone. Speak your doctor if you regularly use any of these medicines, or any another antidepressants.

• Speak your doctor about all another medications you use, especially:

· buspirone (BuSpar);

· cyclosporine (Neoral, Sandimmune, Gengraf);

· digoxin (digitalis, Lanoxin);

· haloperidol (Haldol);

· phenytoin (Dilantin);

· propranolol (Inderal);

· tacrolimus (Prograf);

· triazolam (Halcion);

· a blood thinner such as warfarin (Coumadin);

· cholesterol-lowering medicines such as atorvastatin (Lipitor), simvastatin (Zocor), or lovastatin (Mevacor); or

· any another antidepressant such as desipramine (Norpramin) or fluoxetine (Prozac).

• This list is not complete and there may be another drugs that can interact with nefazodone. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about nefazodone.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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