TIPRANAVIR

(tip RA na veer) Brand: Aptivus

What is the most significant information I must know about tipranavir?

• You must not use this medicine if you are allergic to tipranavir or ritonavir (Norvir, Kaletra), or if you have temperate to severe liver disease.

• Life-threatening side effects can occur if you take tipranavir with any of the next medications: alfuzosin (Uroxatral), amiodarone (Cordarone, Pacerone), cisapride (Propulsid), flecainide (Tambocor), sildenafil (Revatio for pulmonary arterial hypertension), atorvastatin (Lipitor, Caduet), lovastatin (Mevacor, Altoprev, Advicor), simvastatin (Zocor, Simcor, Vytorin, Juvisync), propafenone (Rythmol), rifampin (Rifadin, Rifamate, Rimactane), quinidine (Quin-G), pimozide (Orap), midazolam (Versed), triazolam (Halcion), St. John's wort, or an ergot medication such as Ergomar, Ergotrate, Cafergot, D.H.E. 45, Migranal, or Methergine.

• There are much another medicines that can interact with tipranavir.Tell your doctor about all the prescription and over-the-counter medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity.

• Tipranavir is used in combination with a similar drug called ritonavir (Norvir). Some people taking this combination of medicines have developed life-threatening medical problems including liver hurt and bleeding in the brain. If you are taking these two medications, call your doctor at once if you have any of the next side effects:

· unusual bleeding (such as a nosebleed or blood in your urine or stools);

· problems with walking, breathing, speech, swallowing, or eye movement;

· sudden severe headache, confusion, severe drowsiness;

· sudden numbness or weakness on one side of the body; or

· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

What is tipranavir?

• Tipranavir is an antiviral medicine in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Tipranavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

• Tipranavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Tipranavir is not a cure for HIV or AIDS.

• Tipranavir may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking tipranavir?

• You must not use this medicine if you are allergic to tipranavir or ritonavir (Norvir, Kaletra), or if you have temperate to severe liver disease.

• Life-threatening side effects can occur if you take tipranavir with any of the next medications:

· alfuzosin (Uroxatral),

· amiodarone (Cordarone, Pacerone);

· cisapride (Propulsid);

· atorvastatin (Lipitor, Caduet), lovastatin (Mevacor, Altoprev, Advicor), simvastatin (Zocor, Simcor, Vytorin, Juvisync);

· flecainide (Tambocor), propafenone (Rythmol), quinidine (Quin-G);

· midazolam (Versed) or triazolam (Halcion);

· pimozide (Orap);

· rifampin (Rifadin, Rifamate, Rimactane);

· sildenafil (Revatio for pulmonary arterial hypertension);

· St. John's wort; or

· ergot medicines for migraine headache (Ergomar, Cafergot, D.H.E. 45, Migranal, Ergotrate, or Methergine).

• To create certain you can safely take tipranavir, speak your doctor if you have any of these another conditions:

· liver malady (especially hepatitis B or C);

· diabetes;

· tall cholesterol or triglycerides;

· a bleeding mess such as hemophilia; or

· if you are allergic to sulfa drugs.

• FDA pregnancy category C. It is not known whether tipranavir will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medicine. HIV can be passed to your child if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

• Tipranavir can create birth control pills smaller effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking tipranavir.

• Women with HIV or AIDS must not breast-feed a child. Even if your child is born without HIV, the virus may be passed to the child in your breast milk.

How must I take tipranavir?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Tipranavir is used in combination with a similar drug called ritonavir (Norvir). Take ritonavir at the same time you take tipranavir unless your doctor has told you otherwise.

• Tipranavir works excellent if you take it with food. Swallow the capsule intact. Do not interrupt or chew it.

• Measure liquid medication with a particular dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• To be certain this medication is helping your condition and is not causing deleterious effects, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

• If you need surgery, speak the surgeon onward of time that you are using tipranavir.

• HIV/AIDS is generally treated with a combination of drugs. Use all medications as directed by your doctor. Read the medicine manual or patient instructions provided with every medicine. Do not change your doses or medicine schedule without your doctor's advice. Each face with HIV or AIDS must stay under the care of a doctor.

• Store an unopened bottle of tipranavir capsules in the refrigerator. Do not freeze.

• After opening the bottle of capsules for the first time, you may store the medication at room temperature.

• Store tipranavir oral liquid at room temperature away from moisture and heat. Do not store the liquid in the refrigerator.

• Throw away any capsules or liquid you have not used within 60 days after you first opened the medication bottle.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking tipranavir?

• If you also take didanosine, take it 2 hours till or after you take tipranavir.

• Taking this medicine will not prevent you from passing HIV to another people. Do not have unprotected sex or share razors or toothbrushes. Conversation with your doctor about safety ways to prevent HIV transmission during sex. Sharing drug or medication needles is never safety, even for a healthy person.

What are the possible side effects of tipranavir?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Some people taking tipranavir and ritonavir have developed life-threatening medical problems including liver hurt and bleeding in the brain. If you are taking these two medications, call your doctor at once if you have any of the next side effects:

· unusual bleeding (such as a nosebleed or blood in your urine or stools);

· problems with walking, breathing, speech, swallowing, or eye movement;

· sudden severe headache, confusion, severe drowsiness;

· sudden numbness or weakness on one side of the body; or

· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

• Stop taking tipranavir and call your doctor at once if you have any of these serious side effects:

· severe skin rash, blistering, peeling, or sunburn;

· heighten urination or extreme thirst;

· rapid heart course, heighten sweating, tremors in your hands, anxiety, feeling irritable, sleep problems (insomnia);

· diarrhea, unexplained weight loss, menstrual changes, impotence, loss of interest in sex;

· swelling in your neck or throat (enlarged thyroid);

· muscle weakness, weary feeling, joint or muscle pain, weakness or prickly feeling in your fingers or toes;

· severe lower back pain, loss of bladder or bowel control; or

· signs of a new infection, such as fever or chills, cough, skin lesions, or flu symptoms.

• Smaller serious side effects may include:

· mild nausea, vomiting, stomach pain;

· mild headache or

· changes in the shape or location of body thick (especially in your arms, legs, person, neck, breasts, and waist).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect tipranavir?

• Much drugs can interact with tipranavir. Adown is just a partial list. Speak your doctor if you are using:

· a blood thinner such as warfarin (Coumadin, Jantoven);

· colchicine (Colcrys);

· fluticasone (Advair, Flonase, Flovent);

· insulin or diabetes medicine you take by mouth;

· itraconazole (Sporanox) or ketoconazole (Nizoral);

· methadone (Methadose, Diskets, Dolophine);

· omeprazole (Prilosec);

· rifabutin (Mycobutin);

· rosuvastatin (Crestor);

· salmeterol (Advair, Serevent);

· vitamin E (especially at tall doses);

· an antidepressant such as desipramine (Norpramin), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), trazodone (Desyrel), and others;

· heart or blood pressure medicine such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan);

· drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);

· medicine used to prevent blood clots, such as clopidogrel (Plavix), dipyridamole (Persantine), and others;

· medicines to treat erectile dysfunction, such as Viagra, Cialis or Levitra;

· another HIV /AIDS medication such as atazanavir (Reyataz), enfuvirtide (Fuzeon), fosamprenavir (Lexiva), lopinavir (Kaletra), raltegravir (Isentress), or saquinavir (Invirase); or

· seizure medications such as carbamazepine (Carbatrol, Tegretol), clonazepam (Klonopin), divalproex (Depakote), ethosuximide (Zarontin), lamotrigine (Lamictal), phenobarbital (Solfoton), phenytoin (Dilantin), or valproic acid (Depakene).

• This list is not complete and there are much another drugs that can interact with tipranavir. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about tipranavir.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.