TICLOPIDINE (ORAL)

(tye KLOE pi deen) Brand: Ticlid

What is the most significant information I must know about ticlopidine?

• You must not use this medicine if you are allergic to ticlopidine, or if you have severe liver malady, any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head injury), or a blood cell mess such as anemia (lack of red blood cells) or low levels of platelets (cells that help your blood clot).

• Till taking ticlopidine, speak your doctor if you have a bleeding or blood clotting mess, a history of stroke, including TIA ("mini-stroke"), a stomach ulcer or ulcerative colitis, tall cholesterol or triglycerides, liver malady, or kidney disease.

• Because ticlopidine keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also create it easier for you to bleed, even from a minor injury. Contact your doctor or search abnormal medical attention if you have bleeding that will not stop.

• If you need to have any type of surgery, speak the surgeon onward of time that you are using ticlopidine.

• While you are taking ticlopidine, do not take aspirin or another NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin) without your doctor's advice.

• Taking ticlopidine with determined another drugs can magnify your risk of bleeding. Till taking ticlopidine, speak your doctor about all another medications you use.

What is ticlopidine?

• Ticlopidine keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with determined heart or blood vessel conditions.

• Ticlopidine is used to prevent blood clots after a last heart onslaught or stroke, and in people with determined disorders of the heart or blood vessels.

• Ticlopidine may also be used for another purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking ticlopidine?

• You must not use this medicine if you are allergic to ticlopidine, or if you have:

· severe liver disease;

· any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head injury); or

· a blood cell mess such as anemia (lack of red blood cells) or low levels of platelets (cells that help your blood clot).

• If you have any of these another conditions, you may need a doze adjustment or particular trials to safely take ticlopidine:

· a bleeding or blood clotting mess, such as hemophilia;

· a history of stroke, including TIA ("mini-stroke");

· a stomach ulcer or ulcerative colitis;

· tall cholesterol or triglycerides;

· liver malady; or

· kidney disease.

• FDA pregnancy category B. This medicine is not expected to be deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether ticlopidine passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take ticlopidine?

• Take this medicine exactly as it was predesigned for you. Do not take the medicine in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

• Take this medicine with a full glass of water.

• Take ticlopidine with food.

• To be certain this medicine is not causing deleterious effects, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

• If you need to have any type of surgery, speak the surgeon onward of time that you are using ticlopidine.

• Store ticlopidine at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. If it is nearly time for your following doze, wait before then to take the medication and skip the missed doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medicine.

• Overdose symptoms may include cool feeling, unusual bleeding, trouble breathing, loss of balance or coordination, and seizure (convulsions).

What must I avoid while taking ticlopidine?

• While you are taking ticlopidine, do not take aspirin or another NSAIDs (non-steroidal anti-inflammatory drugs) without your doctor's advice. NSAIDs include ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.

• Avoid sports or activities that could result in a bruising or bleeding injury. Use extra caution to avoid cuts when brushing your teeth or shaving.

• Avoid drinking alcohol while taking ticlopidine. Alcohol may magnify your risk of bleeding in your stomach or intestines.

What are the possible side effects of ticlopidine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using ticlopidine and call your doctor at once if you have a serious side effect such as:

· nosebleed or another bleeding that will not stop;

· black, bloody, or tarry stools;

· coughing up blood or vomit that looks like coffee grounds;

· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling;

· sudden numbness or weakness, especially on one side of the body;

· sudden headache, confusion, problems with vision, speech, or balance; or

· pale skin, light bruising or bleeding, weakness, fever, and urinating more or smaller than usual;

· signs of infection such as fever, chills, sore throat, flu symptoms, mouth sores; or

· nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

• Smaller serious side effects may include:

· upset stomach, nausea, or vomiting;

· ringing in your ears;

· diarrhea;

· dizziness; or

· itching.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect ticlopidine?

• Taking ticlopidine with determined another drugs can magnify your risk of bleeding. Till taking ticlopidine, speak your doctor if you also take:

· aspirin;

· warfarin (Coumadin);

· heparin, dalteparin (Fragmin), or enoxaparin (Lovenox);

· clopidogrel (Plavix);

· dipyridamole (Persantine); or

· an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others.

• Speak your doctor about all another medications you use, especially:

· antacids or cimetidine (Tagamet, Tagamet HB);

· digoxin (Lanoxin, Lanoxicaps);

· theophylline (Elixophyllin, Theo-24, Uniphyl); or

· phenytoin (Dilantin).

• This list is not complete and there may be another drugs that can interact with ticlopidine. Speak your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about ticlopidine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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