RANOLAZINE

(ra NOE la zeen) Brand: Ranexa

What is the most significant information I must know about ranolazine?

• You must not take ranolazine if you have cirrhosis of the liver. There are much another drugs that must not be used together with ranolazine. Speak your doctor about all another medicines you use.

• Ranolazine is not for use during an acute (emergency) onslaught of angina. Continue using any another medicines predesigned by your doctor (such as nitroglycerin) to treat acute angina.

• Till you take ranolazine, speak your doctor about all of your medical conditions, especially if you have a private or family history of Long QT syndrome.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact. Breaking the pill may reason too many of the drug to be released at one time.

• Chronic angina is often treated with a combination of various drugs. To excellent treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medicine schedule without advice from your doctor.

What is ranolazine?

• Ranolazine is an anti-anginal medicine. It works by improving blood flow to help the heart work more efficiently.

• Ranolazine is used to treat chronic angina (chest pain). Ranolazine is not for use during an acute (emergency) onslaught of angina.

• Ranolazine may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking ranolazine?

• You must not take ranolazine if you have cirrhosis of the liver.

• There are much another drugs that must not be used together with ranolazine, such as dexamethasone (Cortastat, Dexasone, Solurex, DexPak), St. John's wort, barbiturates such as phenobarbital, and determined medicines to treat infections, HIV or AIDS, depression, cancer, seizures, tall blood pressure, heart malady, narcolepsy, tuberculosis, or pulmonary arterial hypertension. Before you take ranolazine, speak your doctor about all another medications you are using.

• To create certain you can safely take ranolazine, speak your doctor if you have a private or family history of Long QT syndrome.

• FDA pregnancy category C. It is not known whether ranolazine will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether ranolazine passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using ranolazine.

How must I take ranolazine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Continue using any another medicines predesigned by your doctor (such as nitroglycerin) to treat acute angina.

• Ranolazine may be taken with or without food.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact. Breaking the pill may reason too many of the drug to be released at one time.

• Do not take more than 1000 milligrams of ranolazine two times for day.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose can reason nausea, vomiting, numbness or tingling, dizziness, blurred vision, confusion, or fainting.

What must I avoid while taking ranolazine?

• Ranolazine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Grapefruit and grapefruit juice may interact with ranolazine and lead to potentially dangerous effects. Discuss the use of grapefruit commodity with your doctor.

What are the possible side effects of ranolazine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have any of these serious side effects:

· feeling like you might pass out;

· swelling in your hands, ankles, or feet;

· slow, quick, or pounding heartbeats;

· tremors or shaking;

· blood in your urine;

· urinating smaller than normal or not at all;

· shortness of breath; or

· skin rash, bruising, severe tingling, numbness, pain, and muscle weakness.

• Smaller serious side effects may include:

· mild dizziness, spinning sensation, headache;

· dry mouth;

· mild nausea, vomiting, stomach pain, constipation;

· weakness; or

· ringing in your ears.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect ranolazine?

• Much drugs can interact with ranolazine. Adown is just a partial list. Speak your doctor if you are using:

· aprepitant (Emend);

· arsenic trioxide (Trisenox);

· chloroquine (Aralen);

· digoxin (Lanoxin);

· fluconazole (Diflucan);

· lovastatin (Mevacor, Altoprev, Advicor), simvastatin (Zocor, Simcor, Vytorin);

· tamsulosin (Flomax);

· tolterodine (Detrol);

· ADHD medicine such as atomoxetine (Strattera), dextroamphetamine (Adderall), methamphetamine (Desoxyn), methylphenidate (Ritalin, Daytrana, Metadate, Concerta);

· an antibiotic such as azithromycin (Zithromax), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam);

· an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem, Symbyax), imipramine (Tofranil), mirtazepine (Remeron), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), venlafaxine (Effexor), and others;

· cancer medication such as doxorubicin (Adriamycin, Doxil), lomustine (CeeNU), tamoxifen (Soltamox);

· cough medication such as dextromethorphan (Delsym, Robitussin Maximum Power, Vicks 44, and others) or dihydrocodeine (Alahist DHC, J-Max DHC, Pancof-PD, Panlor, Trezix, Welltuss EXP, and others);

· heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), betaxolol (Kerlone), captopril (Capoten), carvedilol (Coreg), diltiazem (Cartia, Cardizem), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), flecainide (Tambocor), ibutilide (Corvert), labetalol (Normodyne), metoprolol (Dutoprol, Lopressor, Toprol), mexilitene (Mexitil), nicardipine (Cardene), quinidine (Quin-G), pindolol (Visken), procainamide (Procan, Pronestyl), propafenone (Rythmol), propranolol (Inderal, InnoPran), sotalol (Betapace, Sorine), timolol (Blocadren), or verapamil (Calan, Covera, Isoptin);

· medication to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron (Zofran);

· medication to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), fluphenazine (Permitil), haloperidol (Haldol), pimozide (Orap), promethazine (Phenergan), perphenazine (Trilafon), risperidone (Risperdal), thioridazine (Mellaril), or ziprasidone (Geodon);

· medication used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);

· migraine headache medication such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig);

· narcotic medicine such as methadone (Methadose, Diskets, Dolophine); or

· pain medicine such as codeine (Tylenol #3), hydrocodone (Lortab, Vicodin, Vicoprofen), oxycodone (OxyContin, Percocet), or tramadol (Ultram, Ultracet).

• This list is not complete and here are much another drugs that can interact with ranolazine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about ranolazine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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