TRAZODONE

(TRAZ oh done) Brand: Oleptro

What is the most significant information I must know about trazodone?

• You must not use trazodone if you are allergic to it, or if you are being treated with methylene blue injection.

• Do not use trazodone if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

• Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using trazodone. Your family or another caregivers must also be alert to changes in your mood or symptoms.

• Do not give this medicine to anyone under 18 years old without medical advice.

What is trazodone?

• Trazodone is an antidepressant medication. It affects chemicals in the brain that may become unbalanced and reason depression.

• Trazodone is used to treat major depressive disorder.

• Trazodone may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking trazodone?

• You must not use trazodone if you are allergic to it, or if you are being treated with methylene blue injection.

• To create certain trazodone is safety for you, speak your doctor if you have:

· liver or kidney disease;

· heart disease;

· a bleeding or blood clotting disorder;

· seizures or epilepsy;

· bipolar mess (manic depression);

· a history of Long QT syndrome;

· a history of drug abuse or suicidal thoughts;

· if you are being treated with methylene blue injection; or

· if you have recently had a heart attack.

• FDA pregnancy category C. Taking an SSRI antidepressant during pregnancy may reason serious lung problems or another complications in the child. However, you may have a relapse of depression if you stop taking your antidepressant. Speak your doctor right away if you become pregnant while taking trazodone. Do not start or stop taking this medication during pregnancy without your doctor's advice.

• It is not known whether trazodone passes into breast milk or if it could harm a nursing child. Speak your doctor if you are breast-feeding a baby.

• Do not give this medicine to anyone under 18 years old without medical advice.

How must I take trazodone?

• Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.

• The trazodone immediate-release tablet must be taken after a meal or a snack.

• Take the extended-release (Oleptro) tablet on an empty stomach at bedtime, unless your doctor tells you otherwise.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact.

• It may take up to 2 weeks till your symptoms improve. Hold using the medicine as directed and speak your doctor if your symptoms do not improve.

• Do not stop using trazodone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using trazodone.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of trazodone can be fatal when it is taken with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium).

• Overdose symptoms may include extreme drowsiness, vomiting, penis erection that is painful or prolonged, quick or pounding heartbeat, seizure (black-out or convulsions), or breathing that slows or stops.

What must I avoid while taking trazodone?

• Do not drink alcohol. Trazodone can magnify the effects of alcohol, which could be dangerous.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

• Trazodone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of trazodone?

• Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 6 hours or longer. This is a medical abnormal and could lead to a serious condition that should be corrected with surgery.

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

• Call your doctor at once if you have:

· very stiff (rigid) muscles, tall fever, sweating, confusion, quick or uneven heartbeats, tremors, feeling like you might pass out;

· agitation, hallucinations, overactive reflexes, nausea, diarrhea, loss of coordination;

· headache with chest pain and severe dizziness, fainting;

· slurred speech, vomiting, severe weakness, muscle cramps, feeling unsteady, seizure (convulsions), shallow breathing (breathing may stop); or

· chest pain or pressure, tight feeling in your neck or jaw, sweating, pain spreading to your hand or shoulder.

• General side effects may include:

· drowsiness, dizziness, memory problems

· mild headache, weary feeling;

· stomach pain, constipation;

· dry mouth, altered sense of taste;

· back pain; or

· blurred vision.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect trazodone?

• Taking trazodone with another drugs that create you sleepy or slow your breathing can magnify these effects. Ask your doctor till taking trazodone with a sleeping pill, narcotic pain medication, muscle relaxer, or medication for anxiety, depression, or seizures.

• Ask your doctor till taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with trazodone may reason you to bruise or bleed easily.

• Much drugs can interact with trazodone. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with trazodone, especially:

· any another antidepressant medication;

· bosentan;

· imatinib;

· isoniazid;

· St. John's wort;

· methadone;

· tacrolimus;

· arsenic trioxide, vandetanib, vemurafenib;

· an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine, telithromycin;

· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

· anti-malaria medication--artemether and lumefantrine, chloroquine, halofantrine, mefloquine;

· a blood thinner such as warfarin, Coumadin;

· heart rhythm medicine--amiodarone, digoxin, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, nicardipine, procainamide, propafenone, quinidine, sotalol;

· hepatitis C medications--boceprevir, telaprevir;

· HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;

· medication to prevent or treat nausea and vomiting--dolasetron, droperidol, ondansetron;

· medication to treat a psychiatric disorder--chlorpromazine, clozapine, haloperidol, mesoridazine, pimozide, thioridazine, ziprasidone;

· migraine headache medicine--sumatriptan, zolmitriptan;

· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or

· tuberculosis medication--rifabutin, rifampin, rifapentine.

• This list is not complete and much another drugs can interact with trazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about trazodone.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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