TELITHROMYCIN

(tel IT roe MYE sin) Brand: Ketek, Ketek Pak

What is the most significant information I must know about telithromycin?

• Telithromycin may reason sudden and serious liver hurt. In rare cases, liver failure can develop and may reason death. Stop using the medicine and call your doctor right away if you have nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

• You must not take telithromycin if you have a muscle mess called myasthenia gravis, if you are taking cisapride (Propulsid) or pimozide (Orap), or if you have kidney or liver malady AND you are also taking colchicine (Colcrys).

• Do not take this medicine if you have ever had an allergic reaction or liver problems caused by telithromycin or similar antibiotics such as erythromycin (E.E.S., Ery-Tab, Erythrocin, EryPed, Pediazole), azithromycin (Zithromax), clarithromycin (Biaxin), troleandomycin (TAO), or dirithromycin (Dynabac).

• Take this medicine for the full predesigned length of time. Your symptoms may improve till the infection is completely cleared. Skipping doses may also magnify your risk of further infection that is resistant to antibiotics. Telithromycin will not treat a viral infection such as the general cool or flu.

What is telithromycin?

• Telithromycin is an antibiotic. Telithromycin helps the body fight infection that is caused by bacteria.

• Telithromycin is used to treat bacterial infections in the lungs and sinuses.

• Telithromycin may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking telithromycin?

• You must not take this medicine if you are allergic to telithromycin, or if you have:

· myasthenia gravis;

· if you are also taking cisapride (Propulsid) or pimozide (Orap);

· if you have kidney or liver malady AND you are taking colchicine (Colcrys); or

· if you have a history of liver problems caused by telithromycin or similar antibiotics such as erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), azithromycin (Zithromax), clarithromycin (Biaxin), troleandomycin (TAO), or dirithromycin (Dynabac).

• To create certain you can safely take telithromycin, speak your doctor if you have any of these another conditions:

· kidney or liver disease;

· low levels of potassium or magnesium in your blood;

· heart malady or a heart rhythm mess; or

· a private or family history of Long QT syndrome.

• FDA pregnancy category C. It is not known whether telithromycin will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether telithromycin passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take telithromycin?

• Take this medicine exactly as predesigned by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

• Telithromycin can be taken with or without food.

• Do not crush, chew, or interrupt the telithromycin tablet. Swallow it intact.

• Telithromycin is generally taken once a day. Follow your doctor's instructions. Try to take telithromycin at about the same time every day.

• Take this medicine for as much days as it has been predesigned for you even if you begin to feel better. Your symptoms may start to improve till the infection is completely treated. Telithromycin will not treat a viral infection such as the general cool or flu.

• Store this medicine at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. If it is nearly time for your following doze, skip the missed doze and take the medication at the following regularly scheduled time. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medication. Telithromycin is not expected to reason overdose symptoms.

What must I avoid while taking telithromycin?

• This medicine may reason blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

• Antibiotic medicines can reason diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking telithromycin and call your doctor. Do not use anti-diarrhea medication unless your doctor tells you to.

• If you also use theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl, and others), avoid using it within 1 hour till or after you take telithromycin.

What are the possible side effects of telithromycin?

• Telithromycin may reason sudden and serious liver hurt. In rare cases, liver failure can develop and may reason death. Stop using the medicine and call your doctor right away if you have nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using telithromycin and call your doctor at once if you have a serious side effect such as:

· diarrhea that is watery or bloody;

· severe dizziness, fainting, quick or pounding heartbeats;

· confusion, hallucinations; or

· problems with vision (difficulty focusing, double vision).

• Smaller serious side effects may include:

· mild diarrhea;

· mild nausea, vomiting;

· vaginal itching or discharge; or

· changes in your sense of taste.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect telithromycin?

• There are much another drugs that can reason serious drug interactions if you take them together with telithromycin. Speak your doctor about all another medicines you use, especially:

· colchicine (Colcrys);

· cholesterol-lowering medication such as simvastatin (Zocor, Simcor, Vytorin), lovastatin (Mevacor, Altoprev, Advicor), atorvastatin (Lipitor, Caduet); or

· heart or blood pressure medication such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others.

• Much another drugs can interact with telithromycin. Adown is just a partial list. Speak your doctor if you are using:

· a blood thinner such as warfarin (Coumadin, Jantoven);

· cyclosporine (Sandimmune, Gengraf, Neoral);

· digoxin (Lanoxin, Lanoxicaps);

· itraconazole (Sporanox) or ketoconazole (Nizoral);

· metoprolol (Lopressor, Toprol XL);

· rifampin (Rifater, Rifadin, Rifamate);

· tacrolimus (Prograf) or sirolimus (Rapamune);

· ergot medication such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate), or methylergonovine (Methergine);

· heart rhythm medication such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);

· a sedative such as diazepam (Valium), midazolam (Versed), alprazolam (Xanax), chlordiazepoxide (Librium), temazepam (Restoril); or

· seizure medicine such as phenytoin (Dilantin), carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital (Solfoton).

• This list is not complete and there are much another drugs that can interact with telithromycin. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about telithromycin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.