ITRACONAZOLE

(IT ra KON a zole) Brand: Onmel, Sporanox, Sporanox PulsePak

What is the most significant information I must know about itraconazole?

• You must not take this medicine if you are allergic to itraconazole or similar medications such as fluconazole or ketoconazole, if you have ever had congestive heart failure, or if you are pregnant or may become pregnant during treatment.

• Some medicines can reason unwanted or dangerous effects when used with itraconazole. Your doctor may need to change your treatment plan if you use any of the next drugs: cisapride, dihydroergotamine, dofetilide, ergonovine, ergotamine, felodipine, lovastatin, methylergonovine, methadone, midazolam, nisoldipine, pimozide, quinidine, simvastatin, or triazolam.

• Much drugs can interact with itraconazole. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with itraconazole.

• Till taking itraconazole, speak your doctor if you have heart malady, a history of stroke, a heart rhythm mess, kidney or liver malady, a breathing mess, cystic fibrosis, or a history of Long QT syndrome.

• Take this medication for the full predesigned length of time. Your symptoms may improve till the infection is completely cleared. Skipping doses may also magnify your risk of further infection that is resistant to antibiotics. Itraconazole will not treat a viral infection such as the general cool or flu.

What is itraconazole?

• Itraconazole is an antifungal medication.

• Itraconazole is used to treat infections caused by fungus, which can invade any part of the body including the lungs, mouth or throat, toenails, or fingernails.

• Itraconazole may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking itraconazole?

• Some medicines can reason unwanted or dangerous effects when used with itraconazole. Your doctor may need to change your treatment plan if you use any of the next drugs:

· cisapride;

· dofetilide;

· lovastatin or simvastatin;

· methadone;

· midazolam or triazolam;

· felodipine or nisoldipine;

· pimozide;

· quinidine; or

· ergot medicines such as dihydroergotamine, ergonovine, ergotamine, or methylergonovine.

• To create certain itraconazole is safety for you, speak your doctor if you have:

· heart malady, a heart rhythm mess, circulation problems, or a history of stroke;

· chronic obstructive pulmonary malady (COPD) or another breathing disorder;

· kidney disease;

· cirrhosis or another liver disease;

· cystic fibrosis; or

· a private or family history of Long QT syndrome.

• FDA pregnancy category C. It is not known whether itraconazole will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• Itraconazole passes into breast milk and can harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take itraconazole?

• Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• The itraconazole capsule must be taken after a full meal.

• Take itraconazole oral solution (liquid) on an empty stomach, at least 1 hour till or 2 hours after a meal. Swish the liquid in your mouth for different seconds till swallowing it.

• Measure liquid medication with a particular dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• Itraconazole capsules must not be used in seat of itraconazole oral solution (liquid) if that is what your doctor has predesigned. Create certain you have received the correct type of this medicine at the pharmacy and ask the pharmacist if you have any questions.

• While using itraconazole, you may need frequent blood trials at your doctor's office.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking itraconazole?

• Avoid taking antacids or stomach acid reducers (Tagamet, Pepcid, Axid, Zantac, and others) within 1 hour till or 2 hours after you take itraconazole. These medications can create it harder for your body to absorb itraconazole.

What are the possible side effects of itraconazole?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have:

· fever;

· feeling short of breath, even with mild exertion;

· swelling, rapid weight gain;

· ringing in your ears, problems with hearing;

· numbness or tingly feeling, blurred vision, double vision, loss of bladder control;

· pain or burning when you urinate;

· nausea, pain in your upper stomach, itching, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

· severe pain in your upper stomach spreading to your back, nausea and vomiting, quick heart rate.

• Another general side effects may include:

· diarrhea, constipation, bloating, mild nausea;

· unpleasant taste in your mouth;

· mild itching or skin rash;

· joint pain, muscle pain or weakness;

· headache, dizziness; or

· runny nose or another cool symptoms.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect itraconazole?

· a blood thinner such as warfarin, Coumadin;

· cancer medications;

· cholesterol medications such as atorvastatin;

· cyclosporine;

· diabetes medicine you take by mouth;

· digoxin, digitalis;

· disopyramide;

· fentanyl;

· isoniazid (for treating tuberculosis);

· rifabutin, rifampin, or rifapentine;

· sirolimus or tacrolimus;

· an antibiotic such as clarithromycin, erythromycin, or telithromycin;

· an antifungal medicine such as clotrimazole, ketoconazole, or voriconazole;

· an antidepressant such as nefazodone, paroxetine, or sertraline;

· a barbiturate such as amobarbital, butabarbital, mephobarbital, secobarbital or phenobarbital;

· heart or blood pressure medications such as amlodipine, diltiazem, nifedipine, verapamil, and others;

· HIV/AIDS medication such as atazanavir, delavirdine, efavirenz, etravirine, indinavir, nelfinavir, nevirapine, saquinavir, or ritonavir;

· a sedative such as alprazolam or diazepam (Valium); or

· seizure medicine such as carbamazepine, felbamate, oxcarbazepine, phenytoin, or primidone.

• This list is not complete and much another drugs can interact with itraconazole. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about itraconazole.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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