INDINAVIR

(in DIN a veer) Brand: Crixivan

What is the most significant information I must know about indinavir?

• Life-threatening side effects may occur if you take indinavir with alfuzosin (Uroxatral), amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), lovastatin (Mevacor, Altoprev, Advicor), simvastatin (Zocor, Simcor, Vytorin, Juvisync), sildenafil (Revatio, for treating pulmonary arterial hypertension), or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

• There are much another drugs that can reason serious medical problems if you take them together with indinavir. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

• HIV/AIDS is generally treated with a combination of drugs. Use all medications as directed by your doctor. Read the medicine manual or patient instructions provided with every medicine. Do not change your doses or medicine schedule without your doctor's advice. Each face with HIV or AIDS must stay under the care of a doctor.

• Taking this medicine will not prevent you from passing HIV to another people. Do not have unprotected sex or share razors or toothbrushes. Conversation with your doctor about safety ways to prevent HIV transmission during sex. Sharing drug or medication needles is never safety, even for a healthy person.

What is indinavir?

• Indinavir is an antiviral medicine in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

• Indinavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Indinavir is not a cure for HIV or AIDS.

• Indinavir may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking indinavir?

• You must not take this medicine if you are allergic to indinavir.

• To create certain you can safely take indinavir, speak your doctor if you have any of these another conditions:

· liver disease;

· kidney malady, or a history of kidney stones;

· diabetes;

· a bleeding mess such as hemophilia; or

· tall cholesterol or triglycerides.

• FDA pregnancy category C. It is not known whether indinavir will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medicine. HIV can be passed to the child if the mother is not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection while you are pregnant.

• Your name may need to be listed on an antiviral pregnancy registry when you start using this medication.

• Women with HIV or AIDS must not breast feed a child. Even if your child is born without HIV, the virus may be passed to the child in your breast milk.

How must I take indinavir?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• This medicine comes with patient instructions for safety and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

• Take indinavir with a full glass (8 ounces) of water or skim milk. You may also drink juice, coffee, or tea with this medicine. Drink at least 6 glasses of water every day to prevent kidney stones while you are taking indinavir.

• Indinavir must be taken on an empty stomach, at least 1 hour till or 2 hours after a meal.

• If you prefer to take the medicine with food, ate only a easy meal, such as dry toast with jelly, or cereal flakes with skim milk and sugar. Avoid eating a high-fat meal.

• Use indinavir regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.

• To be certain this medication is helping your condition and is not causing deleterious effects, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

• Store at room temperature away from moisture and heat. Hold the capsules in their original container, along with the packet of moisture-absorbing preservative that comes with indinavir capsules.

What happens if I miss a dose?

• If you are smaller than 2 hours late in taking your medication, take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Symptoms of an indinavir overdose may include nausea, vomiting, diarrhea, lower back pain, and blood in your urine.

What must I avoid while taking indinavir?

• If you also take didanosine, take it 1 hour till or after you take indinavir, on an empty stomach.

What are the possible side effects of indinavir?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking indinavir and call your doctor at once if you have any of these serious side effects:

· pain in your side or lower back, blood in your urine;

· pale skin, light bruising or bleeding, confusion or weakness;

· signs of a new infection, such as fever or chills, cough, or flu symptoms;

· rapid heart course, heighten sweating, tremors in your hands, anxiety, feeling irritable, sleep problems (insomnia);

· diarrhea, unexplained weight loss, menstrual changes, impotence, loss of interest in sex;

· swelling in your neck or throat (enlarged thyroid);

· muscle weakness, weary feeling, joint or muscle pain, feeling short of breath;

· weakness or prickly feeling in your fingers or toes;

· problems with walking, breathing, speech, swallowing, or eye movement;

· severe lower back pain, loss of bladder or bowel control;

· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· tall blood sugar -- heighten thirst, heighten urination, famine, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision; or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• Smaller serious side effects may include:

· mild nausea, vomiting;

· numbness or tingling, especially near your mouth;

· headache, mood changes; or

· changes in the shape or location of body thick (especially in your arms, legs, person, neck, breasts, and waist).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect indinavir?

• Much drugs can interact with indinavir. Adown is just a partial list. Speak your doctor if you are using:

· atorvastatin (Lipitor, Caduet) or rosuvastatin (Crestor);

· injectable midazolam (Versed);

· fluticasone (Advair, Flonase, Flovent);

· St. John's wort;

· antibiotics such as clarithromycin (Biaxin), itraconazole (Sporanox), ketoconazole (Nizoral), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, Rifater);

· antidepressants such as trazodone (Desyrel), and others;

· any another HIV/AIDS medications;

· heart or blood pressure medication such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), diltiazem (Cardizem, Cartia, Dilacor, Diltia, Diltzac, Taztia, Tiazac), nifedipine (Nifedical, Procardia), quinidine (Quin-G), verapamil (Calan, Covera, Isoptin, Verelan, Tarka), and others;

· drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);

· insulin or diabetes medicine you take by mouth;

· medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra); or

· seizure medications such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin).

• This list is not complete and there are much another drugs that can interact with indinavir. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about indinavir.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(47)