ENOXAPARIN

(ee nox AP a rin) Brand: Lovenox

What is the most significant information I must know about enoxaparin?

• You must not use this medicine if you are allergic to enoxaparin, heparin, benzyl alcohol, or pork commodity, or if you have active bleeding, or a low level of platelets in your blood after testing positive for a determined antibody while using enoxaparin.

• Speak any doctor who treats you that you are using enoxaparin. If you need anesthesia for a medical procedure or surgery, you may need to stop using the medication for a short time.

Enoxaparin may reason you to bleed more easily, especially if you have: a bleeding mess, hemorrhagic stroke, an infection in the lining of your heart, stomach or intestinal bleeding or ulcer, or if you have had last brain, spine, or eye surgery.

Enoxaparin can reason a very serious blood clot near your brain or spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural), especially if you have a genetic spinal defect, a history of spinal surgery or repeated spinal taps, or if you are using another medications to treat or prevent blood clots. Symptoms of this type of blood clot include numbness, tingling, muscle weakness, or loss of movement.

Blood clots near the brain or spinal cord may occur during a spinal tap or epidural if you use enoxaparin with another drugs that can affect blood clotting, including aspirin, non-steroidal anti-inflammatory drugs (NSAIDs) such as Advil or Motrin, and any another medications to treat or prevent blood clots.

• Much another drugs (including some over-the-counter medicines) can magnify your risk of bleeding or life-threatening blood clots, and it is very significant to speak your doctor about all medicines you have recently used.

• Speak your caregivers at once if you have signs of bleeding such as black or bloody stools, coughing up blood, confusion, feeling like you might pass out, or any bleeding that will not stop.

What is enoxaparin?

Enoxaparin is an anticoagulant that helps prevent the formation of blood clots.

Enoxaparin is used to treat or prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after determined types of surgery, or in people who are bed-ridden due to a prolonged illness.

Enoxaparin is also used to prevent blood vessel complications in people with determined types of angina (chest pain) or heart attack.

Enoxaparin may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till using enoxaparin?

• You must not use this medicine if you are allergic to enoxaparin, heparin, benzyl alcohol, or pork commodity, or if you have:

· active or uncontrolled bleeding; or

· a low level of platelets in your blood after testing positive for a determined antibody while using enoxaparin.

Enoxaparin may reason you to bleed more easily, especially if you have:

· a bleeding mess that is inherited or caused by disease;

· hemorrhagic stroke;

· an infection of the lining of your heart (also called bacterial endocarditis);

· stomach or intestinal bleeding or ulcer; or

· last brain, spine, or eye surgery.

Enoxaparin can reason a very serious blood clot near your brain or spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could reason long-term paralysis, and may be more likely to occur if you have:

· a genetic spinal defect;

· a history of spinal surgery or repeated spinal taps; or

· if you are using another medications to treat or prevent blood clots.

• To create certain you can safely use enoxaparin, speak your doctor if you have another medical conditions, especially:

· kidney or liver disease;

· uncontrolled tall blood pressure;

· eye problems caused by diabetes;

· last stomach ulcer; or

· if you have ever had low blood platelets after receiving heparin.

• FDA pregnancy category B. Enoxaparin is not expected to harm an unborn child. However, some forms of this medicine contain a preservative that may be deleterious to a newborn. Speak your doctor if you are pregnant or plan to become pregnant during treatment. If you use this medicine during pregnancy, create certain your doctor knows if you have a mechanical heart valve.

• It is not known whether enoxaparin passes into breast milk or if it could harm a nursing child. Do not receive this medicine without telling your doctor if you are breast-feeding a baby.

How must I use enoxaparin?

• Use exactly as predesigned by your doctor. Do not use in larger or less amounts or for longer than recommended. Enoxaparin is generally given each day before your bleeding condition improves. Follow the directions on your prescription label.

Enoxaparin is injected under the skin or into a vein through an IV. You may be shown how to use injections at house. Do not self-inject this medication if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and another items used to inject the medicine.

• You must be sitting or lying down during the injection. Do not inject enoxaparin into a muscle.

• Use a various seat on your stomach every time you give an injection under the skin. Your care provider will show you the excellent places on your body to inject the medicine. Do not inject into the same seat two times in a row.

• Prepare your doze in a syringe only when you are ready to give yourself an injection. Do not mix enoxaparin with another medications in the same IV. Do not use the medicine if it has changed colors or has particles in it. Call your doctor for a new prescription.

• Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Hold this container out of the reach of children and pets.

• Speak any doctor who treats you that you are using enoxaparin. If you need surgery or dental work, speak the surgeon or dentist onward of time that you are using this medication.

• To be certain this medicine is not causing deleterious effects, your blood and your stool (bowel movement) may need to be tested often. Your nerve and muscle function may also need to be tested. Visit your doctor regularly.

• Store enoxaparin vials (bottles) at room temperature away from moisture and heat. Once you have used a vial for the first time, the medication will hold at room temperature for up to 28 days. Throw away the vial after 28 days have passed since you first used the vial, even if there is still medication left in it.

What happens if I miss a dose?

• Use the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not use extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Overdose may reason overweening bleeding.

What must I avoid while using enoxaparin?

• Avoid activities that may magnify your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

What are the possible side effects of enoxaparin?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; itching or burning skin; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using enoxaparin and call your doctor at once if you have a serious side effect such as:

· unusual bleeding (nose, mouth, vagina, or rectum), bleeding from wounds or needle injections, any bleeding that will not stop;

· light bruising, purple or red pinpoint spots under your skin;

· pale skin, feeling light-headed or short of breath, rapid heart course, trouble concentrating;

· black or bloody stools, coughing up blood or vomit that looks like coffee grounds;

· numbness, tingling, or muscle weakness (especially in your legs and feet);

· loss of movement in any part of your body;

· sudden weakness, severe headache, confusion, or problems with speech, vision, or balance; or

· trouble breathing.

• Smaller serious side effects may include:

· nausea, diarrhea;

· fever;

· swelling in your hands or foots; or

· mild pain, irritation, redness, or swelling where the medication was injected.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect enoxaparin?

• Much another drugs (including some over-the-counter medicines) can magnify your risk of bleeding, or your risk of developing blood clots near the brain or spinal cord during a spinal tap or epidural. It is very significant to speak your doctor about all medicines you have recently used, especially:

· dextran (Gentran, Hyskon);

· abciximab (ReoPro), eptifibatide (Integrilin), ticagrelor (Brilinta), tirofiban (Aggrastat);

· anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eltrombopag (Promacta), oprelvekin (Neumega), prasugrel (Effient), romiplostim (Nplate), ticagrelor (Brilinta), ticlopidine (Ticlid);

· argatroban (Acova), bivalirudin (Angiomax), dabigatran (Pradaxa), lepirudin (Refludan);

· dalteparin (Fragmin), fondaparinux (Arixtra), heparin, rivaroxaban (Xarelto), tinzaparin (Innohep), warfarin (Coumadin, Jantoven);

· alteplase (Activase), reteplase (Retavase), tenecteplase (TNKase), urokinase (Abbokinase);

· an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or

· salicylates such as aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others.

• This list is not complete and another drugs may interact with enoxaparin. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist can provide more information about enoxaparin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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