TICAGRELOR
(tye KA grel or) Brand: Brilinta
What is the most significant information I must know about ticagrelor?
• You must not use ticagrelor if you have severe liver malady, any active bleeding (including a bleeding stomach ulcer), or a history of bleeding in the brain. Do not use this medication just till heart bypass surgery (coronary artery bypass graft, or CABG).
• You may need to stop using ticagrelor for at least 5 days till having surgery or dental work, to prevent overweening bleeding. Do not stop taking ticagrelor without first talking to your doctor, even if you have signs of bleeding. Stopping ticagrelor may magnify your risk of a heart onslaught or stroke.
• Ticagrelor may reason you to bleed more easily, which can be severe or life-threatening. Avoid activities that may magnify your risk of bleeding or injury.
• Call your doctor or search abnormal medical attention if you have bleeding that will not stop. You may also have bleeding on the internal of your body, such as in your stomach or intestines. Call your doctor at once if you have black or bloody stools, red or pink urine, or if you cough up blood or vomit that looks like coffee grounds. These could be signs of bleeding in your digestive tract.
• Many drugs (including some over-the-counter medicines and herbal products) can reason serious medical problems if you take them with ticagrelor. It is very significant to speak your doctor about all medicines you have recently used.
What is ticagrelor?
• Ticagrelor keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with determined heart or blood vessel conditions.
• Ticagrelor is used to lower your risk of having a stroke or serious heart problems after you have had a heart onslaught or severe chest pain (angina).
• Ticagrelor may also be used for purposes not listed in this medicine guide.
What must I discuss with my healthcare provider till taking ticagrelor?
• You must not use this medicine if you are allergic to ticagrelor, or if you have:
· severe liver disease;
· any active bleeding;
· stomach ulcer or bleeding; or
· a history of bleeding in the brain (such as from a head injury).
• Do not use this medication within 5 days till heart bypass surgery (coronary artery bypass graft, or CABG).
• To create certain ticagrelor is safety for you, speak your doctor if you have:
· liver disease;
· asthma, COPD (chronic obstructive pulmonary disorder) or another breathing problem;
· a history of stomach ulcer or colon polyps;
· a history of stroke; or
· a history of bleeding or blood clotting disorder.
• Ticagrelor may reason you to bleed more easily, especially if you have:
· a last surgery or bleeding injury;
· a malady affecting the blood vessels in your brain;
· a history of stroke;
· a history of bleeding problems;
· a history of stomach or intestinal bleeding; or
· if you are 65 or older.
• FDA pregnancy category C. It is not known whether ticagrelor will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.
• It is not known whether ticagrelor passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.
How must I take ticagrelor?
• Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.
• Ticagrelor must be taken together with aspirin. Follow your doctor's instructions about how many aspirin you must take.
• Do not take more aspirin than your doctor has prescribed. Taking too many aspirin can create ticagrelor smaller effective.
• Ticagrelor can be taken with or without food. Take the medication at the same time every day.
• Because ticagrelor keeps your blood from coagulating (clotting), this medication can also create it easier for you to bleed, even from a minor injury. Contact your doctor or search abnormal medical attention if you have any bleeding that will not stop.
• Any doctor, dentist, surgeon, or another medical care provider who treats you must know that you are taking ticagrelor. You may need to stop using the medication for at least 5 days till having surgery or dental work, to prevent overweening bleeding. Follow your doctor's instructions and start taking ticagrelor again as soon as possible.
• Do not stop taking ticagrelor without first talking to your doctor, even if you have signs of bleeding. Use ticagrelor regularly to get the most benefit. Get your prescription refilled till you run out of medication completely. Stopping ticagrelor may magnify your risk of a heart onslaught or stroke.
• Store at room temperature away from moisture and heat.
What happens if I miss a dose?
• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.
What happens if I overdose?
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Overdose can reason overweening bleeding.
What must I avoid while taking ticagrelor?
• While you are taking ticagrelor, do not take NSAIDs (non-steroidal anti-inflammatory drugs) without your doctor's advice. NSAIDs include ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others.
• Avoid activities that may magnify your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
• Avoid drinking alcohol. It may magnify your risk of bleeding in your stomach or intestines.
• Ask a doctor or pharmacist till using any cool, allergy, pain, or sleep medicine. Aspirin (sometimes abbreviated as ASA) is contained in much combination medicines. Taking determined commodity together can reason you to get too many aspirin which can magnify your risk of bleeding. Check the label to see if a medication contains aspirin or ASA.
What are the possible side effects of ticagrelor?
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have:
· nosebleed or another bleeding that will not stop;
· bloody or tarry stools, blood in your urine;
· coughing up blood or vomit that looks like coffee grounds;
· red or pink urine:
· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling;
· sudden numbness or weakness, especially on one side of the body;
· sudden severe headache, confusion, problems with vision, speech, or balance;
· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
· pale skin, weakness, fever, or jaundice (yellowing of the skin or eyes); or
· if you feel light-headed or short of breath, even with mild exertion or while lying down.
• General side effects may include:
· headache, mild dizziness;
· cough; or
· nausea, diarrhea.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
What another drugs will affect ticagrelor?
• Much drugs can interact with ticagrelor. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with ticagrelor, especially:
· bosentan;
· digoxin;
· imatinib;
· nefazodone;
· St. John's wort;
· an antibiotic--clarithromycin, telithromycin;
· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
· a blood thinner (heparin, warfarin, Coumadin);
· cholesterol-lowering medicine such as lovastatin or simvastatin;
· heart medication--nicardipine, quinidine;
· hepatitis C medications--boceprevir, telaprevir;
· HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;
· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or
· tuberculosis medication--rifabutin, rifampin, rifapentine.
• This list is not complete and much another drugs can interact with ticagrelor. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.
Where can I get more information?
• Your pharmacist can provide more information about ticagrelor.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.