(VEM ue RAF e nib) Brand: Zelboraf
• Do not use vemurafenib if you are pregnant. It could harm the unborn child.
• Till you take vemurafenib, speak your doctor if you have liver malady, an electrolyte imbalance (such as low levels of potassium or magnesium in your blood), or a private or family history of Long QT syndrome.
• Using vemurafenib may magnify your risk of developing another types of skin cancer. Message any new or worsening skin lesions to your doctor right away.
• There are much another drugs that can interact with vemurafenib. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.
• Vemurafenib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
• Vemurafenib is used to treat metastatic melanoma (skin cancer).
• Vemurafenib may also be used for purposes not listed in this medicine guide.
• You must not use vemurafenib if you are allergic to it.
• To create certain you can safely use vemurafenib, speak your doctor if you have any of these another conditions:
· liver disease;
· a heart rhythm disorder;
· a private or family history of Long QT syndrome; or
· an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
• Using vemurafenib may magnify your risk of developing another types of skin cancer. Message any new or worsening skin lesions to your doctor right away.
• FDA pregnancy category D. Do not use vemurafenib if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.
• It is not known whether vemurafenib passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using vemurafenib.
• Till you start treatment, your doctor may perform trials to create certain vemurafenib is the excellent treatment for your type of skin cancer.
• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.
• Vemurafenib is generally taken twice for day, as 2 tablets in the morning and 2 tablets in the evening. Follow your doctor's instructions.
• Take this medication with a full glass of water. You may take vemurafenib with or without food.
• Do not crush, chew, or interrupt a vemurafenib tablet. Swallow it intact.
• To create certain this medicine is helping your condition and not causing deleterious effects, your skin condition will need to be checked often. Your heart function may also need to be tested with an electrocardiogram (ECG or EKG) on a regular basis. You may also need eye exams. Your cancer treatments may be delayed based on the results of these trials. Do not miss any follow-up visits to your doctor.
• Your doctor may want to check your skin for different months after you stop using vemurafenib. Visit your doctor regularly.
• Store at room temperature away from moisture and heat. Hold the bottle tightly closed when not in use.
• Take the missed doze as soon as you remember. Skip the missed doze if your following doze is smaller than 4 hours away. Do not take extra medication to create up the missed doze.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Avoid exposure to sunlight or tanning beds. Vemurafenib can create you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Stop using vemurafenib and call your doctor at once if you have a serious side effect such as:
· severe dizziness, fainting, quick or pounding heartbeats;
· white patches on your eyes;
· new or worsening skin lesions; or
· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.
• Smaller serious side effects may include:
· joint pain;
· weary feeling;
· nausea;
· hair loss;
· mild rash or itching;
· skin growths; or
· blurred vision, heighten sensitivity of your eyes to light.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Much drugs can interact with vemurafenib. Adown is just a partial list. Speak your doctor if you are using:
· a blood thinner such as warfarin (Coumadin, Jantoven);
· cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) or tacrolimus (Prograf);
· digoxin (digitalis, Lanoxin, Lanoxicaps);
· theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
· ADHD medicine such as Adderall, Concerta, Daytrana, Metadate, Ritalin, Strattera;
· an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifampin (Rifater, Rifadin, Rifamate), rifabutin (Mycobutin), rifapentine (Priftin), or telithromycin (Ketek);
· an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), desipramine (Norpramin), doxepin (Sinequan, Silenor), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem, Symbyax), nefazodone, nortriptyline (Pamelor), paroxetine (Paxil, Pexeva), sertraline (Zoloft), venlafaxine (Effexor), and others;
· antifungal medicine such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
· cancer medication such as doxorubicin (Adriamycin, Doxil), lomustine (CeeNU), tamoxifen (Soltamox);
· ergot medication such as ergotamine (Ergomar, Cafergot) or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray);
· cough medication such as dextromethorphan (Delsym, Robitussin Maximum Power, Vicks 44, and others) or dihydrocodeine (Alahist DHC, J-Max DHC, Pancof-PD, Panlor, Trezix, Welltuss EXP, and others);
· pain medicine such as codeine (Tylenol #3), hydrocodone (Lortab, Vicodin, Vicoprofen), oxycodone (OxyContin, Combunox, Roxicodone, Percocet), or tramadol (Ultram, Ultracet);
· heart or blood pressure medicine such as betaxolol (Kerlone), captopril (Capoten), carvedilol (Coreg), labetalol (Normodyne), metoprolol (Dutoprol, Lopressor, Toprol), nicardipine (Cardene), pindolol (Visken), propranolol (Inderal), timolol (Blocadren);
· a heart rhythm medicine such as disopyramide (Norpace), flecainide (Tambocor), mexilitene (Mexitil), procainamide (Procan, Pronestyl), propafenone (Rythmol), or quinidine (Quin-G);
· HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra);
· medication to treat psychiatric disorders, such as chlorpromazine (Thorazine), fluphenazine (Permitil), haloperidol (Haldol), pimozide (Orap), perphenazine (Trilafon), promethazine (Phenergan), risperidone (Risperdal), or thioridazine (Mellaril); or
· seizure medicine such as carbamazepine (Carbatrol, Equetro, Tegretol), divalproex (Depakote), phenobarbital (Solfoton), phenytoin (Dilantin), or valproic acid (Depakene, Stavzor).
• This list is not complete and there are much another drugs that can interact with vemurafenib. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.
• Your pharmacist can provide more information about vemurafenib.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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