ISOCARBOXAZID

(eye so kar BOX a zid) Brand: Marplan

What is the most significant information I must know about isocarboxazid?

• There are much another medicines that can reason serious or life-threatening medical problems if you take them together with isocarboxazid. Do not take isocarboxazid till telling your doctor about all another prescription and over-the-counter medications you use, including vitamins, minerals, and herbal products. Hold a list with you of all the medicines you use and show this list to any doctor, dentist, or another healthcare provider who treats you.

• You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

• Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

• While you are taking isocarboxazid, you should not drink alcohol or ate foods that are tall in tyramine, listed in the "What must I avoid while taking isocarboxazid?" section of this leaflet. Eating tyramine while you are taking isocarboxazid can raise your blood pressure to dangerous levels, causing symptoms that include sudden and severe headache, rapid heartbeat, stiffness in your neck, nausea, vomiting, cool sweat, vision problems, and sensitivity to easy. Stop taking isocarboxazid and call your doctor at once if you have any of these symptoms.

• Isocarboxazid can reason side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What is isocarboxazid?

• Isocarboxazid is a monoamine oxidase inhibitor (MAOI) that works by increasing the levels of determined chemicals in the brain.

• Isocarboxazid is used to treat symptoms of depression that may include anxiety, panic, or phobias. This medicine is generally given after another antidepressants have been tried without successful treatment of symptoms.

• Isocarboxazid may also be used for purposes another than those listed in this medicine guide.

What must I discuss with my doctor till taking isocarboxazid?

• Do not use this medicine if you have used other MAOI such as phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take isocarboxazid till other MAOI has cleared from your body.

• Do not take this medicine if you are allergic to isocarboxazid, or if you have:

· pheochromocytoma (tumor of the adrenal gland);

· a history of stroke or blood clots;

· liver disease;

· kidney disease;

· heart disease;

· tall blood pressure; or

· a history of severe or frequent headaches.

• There are much another medicines that can reason serious or life-threatening medical problems if you take them together with isocarboxazid. The next drugs must not be used while you are taking isocarboxazid:

· diet pills, caffeine, stimulants, ADHD medicine, asthma medicine, over-the-counter cough and cool or allergy medicines;

· blood pressure medication;

· diuretics (water pills);

· bupropion (Wellbutrin, Zyban);

· buspirone (BuSpar);

· carbamazepine (Carbatrol, Tegretol);

· furazolidone (Furoxone);

· meperidine (Demerol, Mepergan);

· pargyline (Eutonyl);

· procarbazine (Matulane);

· alcohol or medicines that create you sleepy (such as cool medication, pain medicine, muscle relaxers, and medication for seizures, depression or anxiety).

· antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adepin, Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil); or

· antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).

• If you have any of these another conditions, you may need an isocarboxazid doze adjustment or particular tests:

· tall blood pressure;

· diabetes;

· a thyroid disorder;

· schizophrenia;

· epilepsy or another seizure disorder;

· if you have taken other antidepressant within the past 5 weeks; or

· if you are also taking tryptophan (L-tryptophan), guanethidine (Ismelin), levodopa (Larodopa, Parcopa, Sinemet), or methyldopa (Aldomet).

• You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Speak your doctor if you have worsening symptoms of depression or suicidal thoughts during the first different weeks of treatment, or whenever your doze is changed.

• Your family or another caregivers must also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

• FDA pregnancy category C. It is not known whether isocarboxazid will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether isocarboxazid passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Do not give isocarboxazid to anyone younger than 16 years old without the advice of a doctor.

How must I take isocarboxazid?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze to create certain you get the excellent results.

• Your blood pressure will need to be tested often. Visit your doctor regularly.

• Take this medicine for the entire length of time predesigned by your doctor. It may take up to 6 weeks or longer till you announcement improvement in your symptoms.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include shallow breathing, quick heart course, sweating, fever, slow reflexes, feeling light-headed, fainting, or seizure (convulsions).

What must I avoid while taking isocarboxazid?

• While you are taking isocarboxazid you should not ate foods that are tall in tyramine, including:

· cheese (especially strong or aged cheeses);

· sour cream and yogurt;

· beer (including non-alcoholic beer), sherry, Chianti wine, liquers;

· dry sausage (such as heavy salami, pepperoni), anchovies, caviar, liver, pickled herring;

· canned figs, raisins, bananas;

· avocados;

· chocolate or caffeine;

· soy sauce;

· sauerkraut;

· fava beans;

· yeast extracts;

· meat extracts;

· meat prepared with tenderizer; or

· over-the-counter supplements or cough and cool medicines that contain dextromethorphan or tyramine.

• You must become very familiar with the list of foods and medicines you should avoid while you are taking isocarboxazid. Eating tyramine while you are taking isocarboxazid can raise your blood pressure to dangerous levels which could reason life-threatening side effects.

• Isocarboxazid may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of isocarboxazid?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using isocarboxazid and call your doctor at once if you have any of these serious side effects:

· sudden and severe headache, rapid heartbeat, stiffness in your neck, nausea, vomiting, cool sweat, sweating, vision problems, sensitivity to light;

· chest pain, quick or slow heart rate;

· swelling, rapid weight gain;

· jaundice (yellowing of the skin or eyes); or

· feeling light-headed, fainting.

• Smaller serious side effects may include:

· dizziness, headache;

· tremors or shaking;

· constipation, nausea; or

· dry mouth.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect isocarboxazid?

• There are much another medicines that can reason serious or life-threatening medical problems if you take them together with isocarboxazid. Do not take isocarboxazid till telling your doctor about all another prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor. Hold a list with you of all the medicines you use and show this list to any doctor, dentist, or another healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about isocarboxzazid.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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