Probably the most common drug interaction of all occurs if alcohol is drunk by those taking other drugs that have CNS depressant activity, the result being even further CNS depression. Blood alcohol levels well within the legal driving limit may, in the presence of other CNS depressants, be equivalent to blood alcohol levels at or above the legal limit in terms of worsened driving and other skills. A less common interaction that can occur between alcohol and some drugs, chemicals, and fungi is the flushing reaction. This is exploited in the case of disulfiram (Antabuse) as an alcohol deterrent. However, it can occur unexpectedly with some other drugs and can be both unpleasant and possibly frightening, but it is not usually dangerous. See also antihypertensives, for general comments about hypertension and alcohol consumption.
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