SELEGILINE (ORAL)

(se LE ji leen) Brand: Eldepryl, Zelapar

What is the most significant information I must know about selegiline?

• There are much another medicines that can reason serious medical problems if you take them together with selegiline. Speak your doctor about all another prescription and over-the-counter medications you use, including vitamins, minerals, and herbal products.

• While taking selegiline, do not drink alcohol or ate foods that are tall in tyramine, listed in the "What must I avoid while using selegiline?" section of this leaflet. Eating tyramine while you are using selegiline can raise your blood pressure to dangerous levels and reason life-threatening symptoms.

• You must become very familiar with the list of foods to avoid while you are using selegiline.

• Do not stop taking selegiline suddenly or you may have deleterious side effects. Hold taking the medication as predesigned. Conversation with your doctor till stopping the medication.

• You may have heighten sexual urges, unusual urges to gamble, or another intense urges while taking this medicine. Conversation with your doctor if you believe you have any intense or unusual urges while taking selegiline.

What is selegiline?

• Selegiline prevents the breakdown of a chemical in your brain called dopamine (DO pa meen). Low levels of this chemical are associated with Parkinson's disease.

• Selegiline is used together with another medicines to treat symptoms of Parkinson's disease.

• Selegiline may also be used for another purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till using selegiline?

• Do not use this medicine if you are allergic to selegiline, or if you have used any of the next drugs within the past 14 days:

· cough or cool medication that contains dextromethorphan;

· meperidine (Demerol), propoxyphene (Darvon, Darvocet), or tramadol (Ultram, Ultracet);

· methadone (Dolophine, Methadose); or

· another MAO inhibitors such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or transdermal selegiline (Emsam).

• After you stop taking selegiline, you should wait at least 14 days till taking any of the medications listed above.

• Till using this medication, speak your doctor if you have kidney malady, liver malady, heart malady, tall or low blood pressure, or a seizure mess. If you have any of these conditions, you may need a doze adjustment or particular trials to safely take selegiline.

• You may have heighten sexual urges, unusual urges to gamble, or another intense urges while taking selegiline. It is not known whether the medication actually causes this effect. Conversation with your doctor if you believe you have any intense or unusual urges while taking selegiline.

• FDA pregnancy category C. It is not known whether this medicine is deleterious to an unborn child. Till you take selegiline, speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether selegiline passes into breast milk or if it could harm a nursing child. Do not take selegiline without telling your doctor if you are breast-feeding a baby.

• The selegiline disintegrating tablets may contain phenylalanine. Conversation to your doctor till using this form of selegiline if you have phenylketonuria (PKU).

How must I take selegiline?

• Take selegiline exactly as it was predesigned for you. Do not take the medicine in larger amounts or for longer than recommended by your doctor. Larger doses will not have any greater effect, but serious side effects could result. Follow the directions on your prescription label.

• While you are using selegiline and for 14 days after you stop, you should not ate foods listed in the "What must I avoid while using selegiline?" section of this leaflet. Eating these foods while you are using selegiline can raise your blood pressure to dangerous levels.

• Foods that you MAY ate include:

· fresh meat, poultry, or fish (including dinner meat, hot dogs, breakfast sausage, and cooked sliced ham);

· any vegetables except broad bean pods (fava beans);

· processed cheese, mozzarella, ricotta, cottage cheese;

· pizza made with cheeses low in tyramine;

· soy milk, yogurt; or

· Brewer's or baker's yeast.

• Selegiline capsules are generally taken twice a day, at breakfast and dinner. Follow your doctor's instructions.

• The disintegrating tablet form of selegiline (Zelapar) must be taken once a day till breakfast and without any liquid.

• To take selegiline orally disintegrating tablets (Zelapar):

· Hold the tablet in its blister pack before you are ready to take the medication. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may hurt the tablet.

· Using dry hands, remove the tablet and seat it in your mouth. It will begin to dissolve right away.

· Do not swallow the tablet intact. Let it to dissolve in your mouth without chewing. Swallow different times as the tablet dissolves.

· Do not drink or ate anything for at least 5 minutes after taking a Zelapar orally disintegrating tablet.

• Parkinson's malady is often treated with a combination of various drugs. To excellent treat your condition, use all of your medications as directed by your doctor. When you start taking selegiline, your doses of the another medications may need to change. Do not change your doses or medicine schedule without advice from your doctor.

• Do not stop taking selegiline suddenly or you may have deleterious side effects. For excellent results, hold taking the medication as prescribed.

• Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the medicine as soon as you remember. If it is nearly time for the following doze, skip the missed doze and wait before your following regularly scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medicine.

• Overdose symptoms may include severe headache, hallucinations, vision problems, sweating, cold or clammy skin, quick or uneven heart course, feeling light-headed, fainting, or seizure (convulsions).

What must I avoid while using selegiline?

• You should NOT ate foods that are tall in tyramine, including:

· air dried meats, aged or fermented meats, sausage or salami (including cacciatore and mortadella), pickled herring, and any spoiled or improperly stored beef, poultry, fish, or liver;

· beer from a tap, beer that has not been pasteurized;

· aged cheeses, including blue, boursault, brick, brie, camembert, cheddar, emmenthaler, gruyere, parmesan, romano, roquefort, stilton, and swiss;

· over-the-counter supplements or cough and cool medicines that contain tyramine;

· sauerkraut, soy beans, soy sauce, tofu, miso soup, bean curd, fava beans; or

· yeast extracts (such as Marmite).

• Eating tyramine while you are taking selegiline can raise your blood pressure to dangerous levels which could reason life-threatening side effects.

• You must become very familiar with the list of foods to avoid while you are taking selegiline.

• Avoid drinking alcohol while taking selegiline.

• Selegiline can reason side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What are the possible side effects of selegiline?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking selegiline and call your doctor at once if you have any of these serious side effects:

· sudden and severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, seizure (convulsions), and sudden numbness or weakness (especially on one side of the body);

· feeling light-headed, fainting;

· hallucinations;

· feeling restless, agitated, or irritable;

· twitching muscle movements; or

· painful or difficult urination.

• Smaller serious side effects may include:

· dizziness, weakness;

· sleep problems (insomnia);

· runny or stuffy nose;

· back pain;

· constipation; or

· mouth sores or ulcers, pain with swallowing (while using Zelapar).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect selegiline?

• Till taking selegiline, speak your doctor if you are using any of the next drugs:

· carbamazepine (Tegretol);

· diet pills or cool medicines that contain ephedrine, pseudoephedrine, or phenylephrine;

· nafcillin (Unipen);

· phenobarbital (Luminal, Solfoton);

· rifampin (Rifadin, Rifater, Rifamate, Rimactane); or

· an antidepressant such as amitriptyline (Elavil), amoxapine (Ascendin), bupropion (Wellbutrin, Zyban), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), venlafaxine (Effexor), or trimipramine (Surmontil).

• This list is not complete and there are much another medicines that can reason serious medical problems if you take them together with selegiline. Do not take selegiline till telling your doctor about all another prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Hold a list with you of all the medicines you use and show this list to any doctor, dentist, or another healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about selegiline.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

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