PROPAFENONE

(proe PAF e none) Brand: Rythmol, Rythmol SR

What is the most significant information I must know about propafenone?

• You must not use this medicine if you have untreated or uncontrolled congestive heart failure, a heart condition called "sick sinus syndrome" or "AV block" (unless you have a pacemaker), slow heartbeats or severely low blood pressure, an electrolyte imbalance, or a breathing mess such as asthma.

• Propafenone may reason a new or worsening heartbeat pattern. Call your doctor at once if you have a headache and chest pain with severe dizziness, fainting, and quick or pounding heartbeats.

What is propafenone?

• Propafenone is in a group of drugs called Class IC anti-arrhythmics. It affects the way your heart beats.

• Propafenone is used in determined situations to prevent serious heart rhythm disorders.

• Propafenone may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking propafenone?

• You must not use this medicine if you are allergic to propafenone, or if you have:

· heart failure;

· a genetic heart condition, especially a determined heart rhythm mess called Brugada syndrome;

· a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker);

· severe low blood pressure, or history of slow heart beats that have caused you to faint;

· a severe or uncontrolled electrolyte imbalance (such as low levels of potassium in your blood); or

· a breathing mess such as severe COPD (chronic obstructive pulmonary disease).

• To create certain propafenone is safety for you, speak your doctor if you have any of these another conditions:

· heart malady or prior heart attack;

· a breathing disorder;

· liver or kidney disease;

· lupus;

· arthritis;

· myasthenia gravis; or

· if you have ever had an emergency blood test called Antinuclear Antibody Test or ANA.

• FDA pregnancy category C. It is not known whether propafenone will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• This medicine may affect fertility (ability to have children) in men. Conversation with your doctor if you have concerns about this risk.

• Propafenone can pass into breast milk and may harm a nursing child. You must not breast-feed while using this medicine.

How must I take propafenone?

• Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.

• You may take propafenone with or without food.

• Your heart function may need to be checked with an electrocardiograph or ECG (sometimes called an EKG), till and during treatment with propafenone.

• You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, extreme thirst, loss of appetite, or if you are sweating more than normal.

• While using propafenone, you may need frequent blood tests.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking propafenone?

• Grapefruit and grapefruit juice may interact with propafenone and lead to unwanted side effects. Avoid the use of grapefruit commodity while taking propafenone.

What are the possible side effects of propafenone?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have:

· shortness of breath (even with mild exertion), swelling, rapid weight gain;

· headache with chest pain and severe dizziness, fainting, quick or pounding heartbeats;

· sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;

· confusion, unusual thoughts or behavior;

· seizure; or

· slow heart course, weak pulse, fainting, slow breathing (breathing may stop).

• General side effects may include:

· nausea, vomiting, constipation;

· headache, weary feeling; or

· unusual or unpleasant taste in your mouth.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect propafenone?

• Many drugs can interact with propafenone and must not be used at the same time. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with propafenone, especially:

· imatinib;

· isoniazid;

· methadone;

· tacrolimus;

· arsenic trioxide, vandetanib, vemurafenib;

· an antibiotic--azithromycin, ciprofloxacin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine, telithromycin;

· an antidepressant--amitriptyline, bupropion, citalopram, clomipramine, desipramine, fluoxetine, fluvoxamine, nefazodone, paroxetine;

· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

· anti-malaria medication--artemether and lumefantrine, chloroquine, halofantrine, mefloquine;

· heart medication--amiodarone, dofetilide, disopyramide, dronedarone, flecainide, ibutilide, nicardipine, procainamide, quinidine, sotalol;

· hepatitis C medications--boceprevir, telaprevir;

· HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir;

· medication to prevent or treat nausea and vomiting--dolasetron, droperidol, ondansetron;

· medication to treat a psychiatric disorder--chlorpromazine, clozapine, haloperidol, mesoridazine, pimozide, thioridazine, ziprasidone; or

· migraine headache medicine--sumatriptan, zolmitriptan.

• This list is not complete and another drugs may interact with propafenone. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about propafenone.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.