RASAGILINE

(ras AJ il een) Brand: Azilect

What is the most significant information I must know about rasagiline?

• Determined medicines must not be taken together with rasagiline. Till you take this medicine, speak your doctor about all another medications you are using, especially muscle relaxers, narcotic pain medication, over-the-counter cough medication, or St. John's wort.

• Do not use rasagiline if you have taken other MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the recent 14 days. Serious, life threatening side effects can occur if you use rasagiline till the another MAO inhibitor has cleared from your body.

• Till you take rasagiline, speak your doctor if you have liver disease.

• There are much another drugs that can reason serious medical problems if you take them together with rasagiline. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

• While you are taking rasagiline and for 2 weeks after you stop taking it, you may not be able to ate determined types of cheese. Follow your doctor's instructions.

• Rasagiline may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What is rasagiline?

• Rasagiline is a monoamine oxidase-B (MAO-B) inhibitor. It works by increasing the levels of determined chemicals in the brain.

• Rasagiline is used to treat the symptoms of Parkinson's malady. Rasagiline is sometimes used with other drug called levodopa.

• Rasagiline may also be used for another purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking rasagiline?

• You must not take rasagiline if you are allergic to it.

• Do not take rasagiline if you have taken any of the next drugs within the past 14 days:

· meperidine (Demerol);

· tramadol (Ultram);

· propoxyphene (Darvon, Darvocet);

· methadone (Methadose, Dolophine);

· St. John's wort;

· cyclobenzaprine (Flexeril, Amrix, Fexmid); or

· dextromethorphan (contained in much over-the-counter cough medicines).

• If you have liver malady, you may need a rasagiline doze adjustment or particular tests.

• Some people taking Parkinson's malady medications have developed skin cancer (melanoma). However, people with Parkinson's malady may have a higher risk of melanoma. Conversation to your doctor about this risk and what skin symptoms to watch for. You may need to have regular skin exams.

• FDA pregnancy category C. It is not known whether rasagiline will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication..

• It is not known whether rasagiline passes into breast milk or if it could harm a nursing child. Rasagiline may slow breast milk manufacture. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take rasagiline?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Rasagiline is generally taken once daily. Your doctor may occasionally change your doze to create certain you get the excellent results.

• If you also take levodopa, your doze may be changed when you start taking rasagiline.

• While you are taking rasagiline and for 2 weeks after you stop taking it, you may not be able to ate determined types of cheese. Follow your doctor's instructions.

• Use rasagiline regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.

• Rasagiline is only part of a complete program of treatment that also includes a diet plan created for you by your doctor or nutrition counselor.

• Do not stop using rasagiline suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using rasagiline.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include drowsiness, dizziness, severe headache, feeling irritable, vision problems, quick and uneven heart course, sweating, cool or clammy skin, shallow breathing, fainting, or seizure (convulsions).

What must I avoid while taking rasagiline?

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

• Rasagiline may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Avoid eating any cheese that your doctor has instructed you not to ate while taking rasagiline.

What are the possible side effects of rasagiline?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using rasagiline and call your doctor at once if you have a serious side effect such as:

· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure);

· sudden numbness or weakness (especially on one side of the body), problems with speech or balance;

· unusual thoughts or behavior,

· agitation, hallucinations, fever, quick heart course, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;

· tremor, muscle twitching or stiffness; or

· feeling like you might pass out.

• Smaller serious side effects may include:

· joint pain;

· mild headache, depressed mood;

· dizziness, spinning sensation;

· hair loss;

· mild skin rash;

· numbness or tingly feeling;

· dry mouth, loss of appetite;

· constipation, diarrhea, stomach pain or upset, vomiting, weight loss;

· impotence, loss of interest in sex, or trouble having an orgasm;

· strange dreams; or

· flu symptoms.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect rasagiline?

• Speak your doctor about all another medicines you have used within the past 14 days, especially:

· ciprofloxacin (Cipro);

· over-the-counter cough, cool, or allergy medicines; or

· an antidepressant such as amitriptyline (Elavil, Vanatrip), citalopram (Celexa), doxepin (Sinequan), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), sertraline (Zoloft), venlafaxine (Effextor), and others.

• This list is not complete and there are much another drugs that can reason serious medical problems if you take them together with rasagiline. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist has more information about rasagiline.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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