TRANYLCYPROMINE

(TRAN il SIP roe meen) Brand: Parnate

What is the most significant information I must know about tranylcypromine?

• There are much another drugs that can reason serious medical problems if you take them together with tranylcypromine. Do not take tranylcypromine till telling your doctor about all another prescription and over-the-counter medications you use, including vitamins, minerals, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

• You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

• Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

• While you are taking tranylcypromine, you should not drink alcohol or ate foods that are tall in tyramine, listed in the "What must I avoid while taking tranylcypromine?" section of this leaflet. Eating tyramine while you are taking tranylcypromine can raise your blood pressure to dangerous levels, causing life-threatening symptoms such as sudden and severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, seizure (convulsions), and sudden numbness or weakness (especially on one side of the body). Call your doctor at once if you have any of these symptoms.

• Tranylcypromine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What is tranylcypromine?

• Tranylcypromine is a monoamine oxidase inhibitor (MAOI) that works by increasing the levels of determined chemicals in the brain.

• Tranylcypromine is used to treat major depressive episode in adults. This medicine is generally given after another anti-depressants have been tried without successful treatment of symptoms. Tranylcypromine will not treat bipolar mess (manic depression).

• Tranylcypromine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking tranylcypromine?

• Do not use this medicine if you have used other MAOI such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take tranylcypromine till other MAOI has cleared from your body. If you are switching to tranylcypromine from other MAOI, your doctor may start you at a low dose.

• There are much another medicines that can reason serious medical problems if you take them together with tranylcypromine. The next drugs must not be used while you are taking tranylcypromine:

· an antidepressant;

· blood pressure medication such as guanethidine (Ismelin), methyldopa (Aldomet), and reserpine;

· diet pills, stimulants, ADHD medications, over-the-counter cough and cool or allergy medicines;

· doxepin (Adapin, Sinequan);

· carbamazepine (Carbatrol, Tegretol);

· cyclobenzaprine (Flexeril);

· maprotiline (Ludiomil);

· procarbazine (Matulane);

· bupropion (Wellbutrin, Zyban);

· venlafaxine (Effexor);

· buspirone (BuSpar);

· tryptophan (also called L-tryptophan);

· levodopa (Larodopa, Parcopa, Sinemet); or

· meperidine (Demerol, Mepergan).

• To create certain you can safely take tranylcypromine, speak your doctor if you have any of these another conditions:

· heart malady, tall blood pressure, circulation problems, or a history of stroke;

· a history of headaches (migraine, cluster, or another types);

· diabetes; or

· a seizure mess such as epilepsy.

• You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Speak your doctor if you have worsening depression or suicidal thoughts during the first different weeks of treatment, or whenever your doze is changed.

• Your family or another caregivers must also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

• Tranylcypromine may be habit forming and must be used only by the face it was predesigned for. Never share tranylcypromine with other face, especially somebody with a history of drug abuse or addiction. Hold the medicine in a seat where others can't get to it.

• It is not known whether tranylcypromine will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• Tranylcypromine can pass into breast milk and may harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Older adults may be more likely to have side effects from tranylcypromine.

• Do not give this medication to a baby younger than 18 years old without medical advice.

How must I take tranylcypromine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze to create certain you get the excellent results.

• Your blood pressure will need to be tested often. Visit your doctor regularly.

• You may need to stop using the medication for a short time if you need to have any type of surgery, or if you will have an x-ray, CT scan, or MRI of your spinal cord. Speak any doctor who treats you that you are taking tranylcypromine.

• It may take 4 weeks or longer till your symptoms improve. Hold using the medicine as directed and speak your doctor if your symptoms do not improve after 4 weeks of treatment.

• Do not stop using tranylcypromine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using tranylcypromine. You may need to use smaller and smaller till you stop the medicine completely.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include feeling restless or anxious, sleep problems (insomnia), agitation, confusion, weakness, severe headache, neck pain or stiffness, quick or pounding heart beats, chest pain, cool sweats, feeling light-headed, or fainting.

What must I avoid while taking tranylcypromine?

• While you are taking tranylcypromine, you should not ate foods that are tall in tyramine, including:

· avocados, bananas, figs, raisins, and sauerkraut;

· beef or chicken liver, fish, meats prepared with tenderizer, bologna, pepperoni, salami, summer sausage, game meat, meat extracts, caviar, dried fish, herring, and shrimp paste;

· beer (alcoholic and nonalcoholic), red wine (especially Chianti), sherry, vermouth, and another distilled spirits;

· caffeine (including coffee, tea, cola); and

· cheeses, including American, blue, boursault, brick, brie, camembert, cheddar, emmenthaler, gruyere, mozzarella, parmesan, romano, roquefort, stilton, and Swiss;

· chocolate;

· ginseng;

· sour cream and yogurt;

· soy sauce, miso soup, bean curd, fava beans; or

· yeast extracts.

• Eating tyramine while you are taking tranylcypromine can raise your blood pressure to dangerous levels, causing life-threatening side effects.

• Drinking alcohol can magnify determined side effects of tranylcypromine.

• Tranylcypromine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of tranylcypromine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Message any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

• Stop using tranylcypromine and call your doctor at once if you have any of these serious side effects:

· frequent headaches, vision problems, sensitivity to light;

· quick or pounding heart beats, tight feeling in your chest or throat;

· swelling of your ankles or feet;

· pale skin, light bruising or bleeding, unusual weakness;

· nausea, vomiting, dizziness, sweating, stiffness in your neck;

· confusion, lack of coordination, feeling light-headed, fainting; or

· tremors, muscle twitches you can't control.

• Smaller serious side effects may include:

· feeling restless, weak, or drowsy;

· nausea, diarrhea or constipation, loss of appetite, stomach pain;

· chills, numbness or tingly feeling;

· dry mouth, decreased urination;

· blurred vision, ringing in your ears; or

· impotence, difficulty having an orgasm.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect tranylcypromine?

Where can I get more information?

• Your pharmacist can provide more information about tranylcypromine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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