DOFETILIDE

(doe FET i lide) Brand: Tikosyn

What is the most significant information I must know about dofetilide?

• Dofetilide is accessible only from a hospital or specialty pharmacy.

• You must not take dofetilide if you are allergic to it, or if you have severe kidney malady (or you are on dialysis) or a history of Long QT syndrome.

• Till you receive dofetilide, speak your doctor if you have heart malady, tall blood pressure, kidney malady, severe liver malady, depression, mental diseases, or an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

• There are much another drugs that must not be used together with dofetilide. Speak your doctor about all another medicines you use.

• You will need to spend at least 3 days in a hospital setting when you first start taking dofetilide. This is so your heart rhythm and kidney function can be monitored in case the medicine causes serious side effects.

• Speak your doctor if you have a prolonged diseases that causes severe diarrhea, vomiting, hard sweating, heighten thirst, or loss of appetite. These conditions can reason an electrolyte imbalance (such as low potassium levels), making it dangerous for you to use dofetilide.

• Your blood pressure will need to be checked often. Visit your doctor regularly.

What is dofetilide?

• Dofetilide is a heart rhythm medicine, also called an antiarrhythmic.

• Dofetilide is used to help hold the heart beating normally in people with determined heart rhythm disorders of the atrium (the upper chambers of the heart that let blood to flow into the heart). Dofetilide is used in people with atrial fibrillation or atrial flutter.

• Dofetilide may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking dofetilide?

• You must not take dofetilide if you are allergic to it, or if you have

· severe kidney malady (or you are on dialysis); or

· a history of Long QT syndrome.

• There are much another drugs that can reason serious or life threatening medical problems if you take them together with dofetilide. The next drugs must not be used while you are taking dofetilide:

· cimetidine (Tagamet);

· ketoconazole (Nizoral);

· megestrol (Megace);

· prochlorperazine (Compazine);

· trimethoprim (Proloprim, Trimpex, Bactrim, Cotrim, Septra);

· verapamil (Covera, Calan, Isoptin, Verelan); or

· a diuretic (water pill) that contains hydrochlorothiazide (HCTZ), such as Accuretic, Aldactazide, Aldoril, Amturnide, Atacand HCT, Avalide, Benicar HCT, Capozide, Diovan HCT, Dyazide, Exforge HCT, Hyzaar, Hydra-Zide, HydroDiuril, Inderide, Lopressor HCT, Lotensin HCT, Maxzide, Micardis HCT, Moduretic, Monopril HCT, Prinzide, Tekturna HCT, Teveten HCT, Tribenzor, Uniretic, Vaseretic, Zestoretic, Ziac, and others.

• To create certain you can safely take dofetilide, speak your doctor if you have any of these another conditions:

· heart malady, tall blood pressure;

· kidney disease;

· severe liver disease;

· depression, mental diseases; or

· an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

• FDA pregnancy category C. It is not known whether dofetilide will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether dofetilide passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using dofetilide.

How must I take dofetilide?

• Dofetilide is accessible only from a hospital or specialty pharmacy.

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Dofetilide comes with patient instructions for safety and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

• You may take dofetilide with or without food.

• Do not skip doses or stop taking dofetilide without first talking to your doctor. Stopping suddenly may create your condition worse. You may need to use smaller and smaller till you stop the medicine completely.

• Speak your doctor if you have a prolonged diseases that causes severe diarrhea, vomiting, or hard sweating. These conditions can reason an electrolyte imbalance, making it dangerous for you to use dofetilide.

• Your blood pressure will need to be checked often. Your kidney function may also need to be checked with frequent blood trials. Visit your doctor regularly.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include some of the serious side effects listed in this medicine guide.

What must I avoid while taking dofetilide?

• Grapefruit and grapefruit juice may interact with dofetilide and lead to potentially dangerous effects. Discuss the use of grapefruit commodity with your doctor.

What are the possible side effects of dofetilide?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· headache with chest pain and severe dizziness;

· quick or pounding heartbeats, feeling like you might pass out;

· low magnesium (confusion, uneven heart course, jerking muscle movements, muscle weakness or limp feeling); or

· low potassium (confusion, uneven heart course, extreme thirst, heighten urination, leg discomfort, muscle weakness or limp feeling).

• Smaller serious side effects may include:

· mild headache;

· mild dizziness;

· sleep problems (insomnia);

· back pain;

· nausea, diarrhea, stomach pain;

· cool symptoms such as stuffy nose, sneezing, sore throat; or

· mild skin rash.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect dofetilide?

• Much drugs can interact with dofetilide. Adown is just a partial list. Speak your doctor if you are using:

· arsenic trioxide (Trisenox);

· conivaptan (Vaprisol);

· imatinib (Gleevec);

· isoniazid (for treating tuberculosis);

· tacrolimus (Prograf);

· an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), or pentamidine (NebuPent, Pentam);

· an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), desipramine (Norpramin), fluvoxamine (Luvox), sertraline (Zoloft), and others;

· antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);

· anti-malaria medications such as chloroquine (Aralen) or mefloquine (Lariam);

· a diuretic (water pill) such as amiloride amiloride (Midamor), triamterene triamterene (Dyrenium), and others;

· heart rhythm medication such as amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), disopyramide (Norpace), dronedarone (Multaq), ibutilide (Corvert), nicardipine (Cardene), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);

· HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra);

· medication to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron (Zofran);

· medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);

· migraine headache medication such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig);

· narcotic medicine such as methadone (Methadose, Diskets, Dolophine); or

· oral diabetes medications that contain metformin (Actoplus Met, Avandamet, Glucophage, Glucovance, Janumet, Kombiglyze, Metaglip, Prandimet).

• This list is not complete and another drugs may interact with dofetilide. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist can provide more information about dofetilide.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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