VANDETANIB

(van DET a nib) Brand:

What is the most significant information I must know about vandetanib?

• Do not use vandetanib if you are pregnant. It could harm the unborn baby.

• Till you take vandetanib, speak your doctor if you have liver or kidney malady, tall blood pressure, heart malady, heart rhythm mess, seizures, skin problems, severe diarrhea, breathing problems, last stomach or intestinal bleeding, a family history of Long QT syndrome, or low levels of calcium, magnesium, or potassium in your blood.

• There are much another drugs that can interact with vandetanib. Speak your doctor about all medications you use.

• To be certain this medicine is not causing deleterious effects, your blood may need to be tested often. Your heart course may also need to be checked using an electrocardiograph or ECG (sometimes called an EKG). If you need surgery, speak the surgeon onward of time that you are using vandetanib. You may need to stop using the medication for a short time.

• Do not stop taking this medicine unless your doctor tells you to. If you stop taking vandetanib for longer than 2 weeks for any cause, do not start taking it again without your doctor's advice.

What is vandetanib?

• Vandetanib is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

• Vandetanib is used to treat thyroid cancer.

• Vandetanib may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking vandetanib?

• You must not use this medicine if you are allergic to it, or if you have a history of Long QT syndrome.

• To create certain you can safely take vandetanib, speak your doctor if you have any of these another conditions:

· liver or kidney disease;

· tall blood pressure, heart malady, heart rhythm disorder;

· a family history of Long QT syndrome;

· epilepsy or another seizure disorder;

· low levels of calcium, magnesium, or potassium in your blood;

· skin problems;

· severe diarrhea;

· a history of breathing problems; or

· last stomach or intestinal bleeding.

• Vandetanib is accessible only under a particular program. You should be registered in the program and sign documents stating that you understand the risks and benefits of taking this medication.

• FDA pregnancy category D. Do not use vandetanib if you are pregnant. It could harm the unborn child. Speak your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine and for at least 4 months after your treatment ends.

• It is not known whether vandetanib passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are taking vandetanib.

How must I take vandetanib?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• You may take vandetanib with or without food.

• Vandetanib is generally taken once for day. Your doctor may occasionally change your doze to create certain you get the excellent results.

• Do not crush a vandetanib tablet. Swallow the pill intact. Crushing the pill may reason your body to absorb too many of the drug at one time. The medication from a crushed or broken pill can be dangerous if it gets on your skin. If this occurs, wash your skin with soap and water and rinse thoroughly.

• To create swallowing easier, seat the tablet into a glass of water (2 ounces) and let the tablet to disperse in the water. The tablet will not dissolve completely. Drink this mixture right away. To create certain you get the entire doze, add a few more liquid to the same glass, swirl gently and drink right away.

• If you need surgery, speak the surgeon onward of time that you are using vandetanib. You may need to stop using the medication for a short time.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if your following doze is smaller than 12 hours away. Do not take extra medication to create up the missed doze.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while taking vandetanib?

• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Avoid exposure to sunlight or tanning beds. Vandetanib can create you sunburn more easily, for up to 4 months after you stop taking the medication. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of vandetanib?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using vandetanib and call your doctor at once if you have a serious side effect such as:

· slow healing of a wound or surgical incision;

· severe dizziness, fainting, quick or pounding heartbeats;

· fever, chest pain, dry cough, wheezing, trouble breathing;

· feeling short of breath (even with mild exertion), swelling, rapid weight gain;

· chest pain or hard feeling, pain spreading to the hand or shoulder;

· severe or ongoing diarrhea;

· black, bloody, or tarry stools;

· coughing up blood or vomit that looks like coffee grounds;

· confusion, vision problems, headache, seizure (convulsions), problems with thinking;

· sudden numbness or weakness (especially on one side of the body), sudden headache, confusion, problems with speech or balance;

· thyroid symptoms -- extreme weary feeling, dry skin, joint pain or stiffness, muscle pain or weakness, hoarse voice, feeling more sensitive to cool temperatures, weight gain; or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• Smaller serious side effects may include:

· mild feeling tired;

· headache;

· mild nausea or stomach pain;

· diarrhea;

· mild skin rash; or

· acne.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect vandetanib?

• Much drugs can interact with vandetanib. Adown is just a partial list. Speak your doctor if you are using:

· arsenic trioxide (Trisenox);

· bosentan (Tracleer);

· dexamethasone (Cortastat, Dexasone, Solurex, DexPak);

· St. John's wort;

· tacrolimus (Prograf);

· an antibiotic such as azithromycin (Zithromax, Zmax, Z-Pack), clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);

· an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), citalopram (Celexa), clomipramine (Anafranil), or desipramine (Norpramin);

· anti-malaria medications such as chloroquine (Aralen), halofantrine (Halfan), or mefloquine (Lariam);

· a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

· heart rhythm medication such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), flecainide (Tambocor), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);

· HIV medicine such as efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir, Kaletra);

· medication to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron (Zofran);

· medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil);

· medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);

· migraine headache medication such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig);

· narcotic medicine such as methadone (Methadose, Diskets, Dolophine); or

· seizure medicine such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

• This list is not complete and there are much another drugs that can interact with vandetanib. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about vandetanib.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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