ONDANSETRON (ORAL)

(on DAN se tron) Brand: Zofran, Zofran ODT, Zuplenz

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What is the most significant information I must know about ondansetron?

• You must not use this medicine if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Do not take ondansetron if you are also using apomorphine (Apokyn).

• Till taking ondansetron, speak your doctor if you have liver malady, or a private or family history of Long QT syndrome.

Ondansetron orally disintegrating tablets may contain phenylalanine. Speak your doctor if you have phenylketonuria (PKU).

• The serious side effects of this medicine include blurred vision or temporary vision loss (lasting from only a little minutes to different hours), slow heart course, trouble breathing, anxiety, agitation, shivering, feeling like you might pass out, and urinating smaller than normal or not at all. Stop taking ondansetron and call your doctor at once if you have any of these side effects.

Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What is ondansetron?

Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medication to treat cancer (chemotherapy or radiation).

Ondansetron may be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking ondansetron?

• You must not use this medicine if you are allergic to ondansetron, to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Do not take ondansetron if you are also using apomorphine (Apokyn).

• To create certain you can safely take ondansetron, speak your doctor if you have any of these another conditions:

· liver malady;

· heart malady, congestive heart failure, a heart rhythm disorder;

· an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or

· a private or family history of Long QT syndrome.

• FDA pregnancy category B. This medicine is not expected to be deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether ondansetron passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

ondansetron must not be given to a baby younger than 4 years old.

Ondansetron orally disintegrating tablets may contain phenylalanine. Speak your doctor if you have phenylketonuria (PKU).

How must I take ondansetron?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

Ondansetron can be taken with or without food.

• Take the ondansetron regular tablet with a full glass of water.

• To take ondansetron orally disintegrating tablet (Zofran ODT):

· Hold the tablet in its blister pack before you are ready to take the medication. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may hurt the tablet.

· Using dry hands, remove the tablet and seat it in your mouth. It will begin to dissolve right away.

· Do not swallow the tablet intact. Let it to dissolve in your mouth without chewing.

· Swallow different times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

• To use ondansetron oral soluble movie (strip) (Zuplenz):

· Hold the strip in the foil pouch before you are ready to use the medicine.

· Using dry hands, remove the strip and seat it on your tongue. It will begin to dissolve right away.

· Do not swallow the strip intact. Let it to dissolve in your mouth without chewing.

· Swallow different times after the strip dissolves. If desired, you may drink liquid to help swallow the dissolved strip.

· Wash your hands after using Zuplenz.

• Measure the liquid form of ondansetron with a particular dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• Your heart function may need to be tested with an electrocardiogram (ECG or EKG) on a regular basis. Do not miss any follow-up visits to your doctor.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.

What must I avoid while taking ondansetron?

Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of ondansetron?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· blurred vision or temporary vision loss (lasting from only a little minutes to different hours);

· severe dizziness, feeling short of breath, fainting, quick or pounding heartbeats;

· slow heart course, trouble breathing;

· anxiety, agitation, shivering;

· feeling like you might pass out; or

· urinating smaller than normal or not at all.

• Smaller serious side effects may include:

· diarrhea or constipation;

· weakness or weary feeling;

· fever;

· headache; or

· dizziness, drowsiness.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect ondansetron?

• Speak your doctor about all another medicines you use, especially:

· arsenic trioxide (Trisenox);

· tacrolimus (Prograf);

· tramadol (Ultram, Ultracet);

· an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam), or rifampin (Rifadin, Rimactane, Rifater);

· an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), or desipramine (Norpramin);

· anti-malaria medications such as chloroquine (Aralen) or mefloquine (Lariam);

· heart rhythm medication such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);

· medication to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron (Zofran);

· medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);

· migraine headache medication such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig);

· narcotic medicine such as methadone (Methadose, Diskets, Dolophine); or

· seizure medicine such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal).

• This list is not complete and another drugs may interact with ondansetron. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about ondansetron.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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