DUTASTERIDE AND TAMSULOSIN

(doo TAS ter ide and tam soo LOE sin) Brand: Jalyn

What is the most significant information I must know about dutasteride and tamsulosin?

• You must not use this medicine if you are allergic to dutasteride (Avodart) or tamsulosin (Flomax). Do not take dutasteride and tamsulosin if you are also taking alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin).

• Dutasteride and tamsulosin must never be taken by a woman, a baby, or a teenager. Dutasteride can be absorbed through the skin, and women or children must not be permitted to handle dutasteride and tamsulosin capsules.

• This medicine can reason birth defects if a woman is exposed to it during pregnancy. Dutasteride and tamsulosin capsules must not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medicine from a leaking capsule, wash the area with soap and water right away.

• Do not donate blood while taking this medicine and for at least 6 months after your treatment ends. Dutasteride can be carried in the blood and could reason birth defects if a pregnant women receives a transfusion with blood that contains dutasteride.

• Using dutasteride and tamsulosin may magnify your risk of developing prostate cancer. Your doctor will perform trials to create certain you do not have another conditions that would prevent you from safely using dutasteride and tamsulosin.

• Tamsulosin can affect your pupils during cataract surgery. Speak your eye surgeon onward of time that you are using this medicine. Do not stop using dutasteride and tamsulosin till surgery unless your surgeon tells you to.

• There are much another drugs that can interact with dutasteride and tamsulosin. Speak your doctor about all medications you use.

What is dutasteride and tamsulosin?

• Dutasteride prevents the transformation of testosterone to dihydrotestosterone (DHT) in the body. DHT is involved in the development of benign prostatic hyperplasia (BPH).

• Tamsulosin is in a group of drugs called alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Tamsulosin relaxes the muscles in the prostate and bladder neck, making it easier to urinate.

• The combination of dutasteride and tamsulosin is used to treat benign prostatic hyperplasia (BPH) in men with an enlarged prostate.

• Dutasteride and tamsulosin may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking dutasteride and tamsulosin?

• You must not use this medicine if you are allergic to dutasteride (Avodart) or tamsulosin (Flomax).

• Do not take dutasteride and tamsulosin if you are also taking alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin).

• To create certain you can safely take this medicine, speak your doctor if you have any of these another conditions:

· low blood pressure;

· tall blood pressure (hypertension);

· liver disease;

· severe kidney disease;

· a history of prostate cancer; or

· if you are allergic to sulfa drugs or to finasteride (Propecia, Proscar).

• Although dutasteride and tamsulosin is not for use by women, this medicine can reason birth defects if a woman is exposed to it during pregnancy. Dutasteride and tamsulosin capsules must not be handled by a woman who is pregnant or who may become pregnant.

• If a woman accidentally comes into contact with this medicine from a leaking capsule, wash the area with soap and water right away.

How must I take dutasteride and tamsulosin?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Dutasteride and tamsulosin is generally taken once a day, approximately 30 minutes after a meal. Try to take this medicine at the same time every day.

• Do not crush, chew, or open a dutasteride and tamsulosin capsule. Swallow it intact. A broken or leaking dutasteride and tamsulosin capsule can irritate your lips, mouth, or throat.

• Tamsulosin lowers blood pressure and may reason dizziness or fainting, especially when you first start taking dutasteride and tamsulosin. Call your doctor if you have severe dizziness or feel like you might pass out.

• It may take up to 6 months till your symptoms improve. Hold using the medicine as directed and speak your doctor if your symptoms do not improve.

• To be certain this medicine is helping your condition and not causing deleterious effects, your blood may need to be tested often. Your doctor will also test your prostate specific antigen (PSA) to check for prostate cancer. Visit your doctor regularly.

• Store at room temperature away from moisture and heat. Do not use a capsule that has been exposed to tall heat, which can reason the capsule to change shape or color.

What happens if I miss a dose?

• Take the missed doze 30 minutes after your following meal. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

• If you miss your doses for different days in a row, contact your doctor till restarting the medicine. You may need a lower dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include extreme dizziness or fainting.

What must I avoid while taking dutasteride and tamsulosin?

• Dutasteride and tamsulosin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What are the possible side effects of dutasteride and tamsulosin?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop taking this medicine and call your doctor at once if you have a serious side effect such as:

· feeling like you might pass out; or

· penis erection that is painful or lasts 4 hours or longer.

• Smaller serious side effects may include:

· decreased libido (sex drive);

· decreased amount of semen released during sex;

· impotence (trouble getting or keeping an erection);

· breast tenderness or enlargement;

· mild dizziness; or

· runny nose.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect dutasteride and tamsulosin?

• Speak your doctor about all another medications you use, especially:

· cimetidine (Tagamet);

· conivaptan (Vaprisol);

· cyclosporine (Gengraf, Neoral, Sandimmune);

· imatinib (Gleevec);

· isoniazid (for treating tuberculosis);

· methimazole (Tapazole);

· pioglitazone (Actos);

· ropinirole (Requip);

· ticlopidine (Ticlid);

· a blood thinner such as warfarin (Coumadin, Jantoven);

· an antibiotic such as clarithromycin (Biaxin), doxycycline (Adoxa, Alodox, Avidoxy, Oraxyl, Doryx, Oracea, Vibramycin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), metronidazole (Flagyl, Protostat), telithromycin (Ketek), terbinafine (Lamisil), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap);

· an antidepressant such as clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem), nefazodone, paroxetine (Paxil), sertraline (Zoloft), tranylcypromine (Parnate), or trazodone (Desyrel, Oleptro);

· antifungal medicine such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);

· anti-malaria medicine such as chloroquine (Arelan) or pyrimethamine (Daraprim), or quinine (Qualaquin);

· erectile dysfunction medication such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);

· heart or blood pressure medicine such as amiodarone (Cordarone, Pacerone), nicardipine (Cardene), or quinidine (Quin-G), and others;

· HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir); or

· medication to treat psychiatric disorders, such as aripiprazole (Abilify), chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), perphenazine (Trilafon), or thioridazine (Mellaril).

• This list is not complete and there are much another drugs that can interact with dutasteride and tamsulosin. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about dutasteride and tamsulosin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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