PYRIMETHAMINE

(PIR i METH a meen) Brand: Daraprim

What is the most significant information I must know about pyrimethamine?

• Stop taking pyrimethamine and search medical attention at the first sign of a skin rash, sore throat, paleness of the skin, unusual bruising under the skin, or swelling of the tongue. These may be early symptoms of serious side effects of pyrimethamine.

• Pyrimethamine may reason stomach upset or vomiting. Take every doze with food to lessen this side effect.

What is pyrimethamine?

• Pyrimethamine is an antiparasitic drug. It prevents the growth and reproduction of parasites.

• Pyrimethamine is used to treat and prevent malaria. Pyrimethamine is also used in the treatment of toxoplasmosis.

• Pyrimethamine may also be used for purposes another than those listed in this medicine guide.

What must I discuss with my healthcare provider till taking pyrimethamine?

• Till taking pyrimethamine, speak your doctor if you have

· had an allergic reaction to previous treatment with pyrimethamine,

· megaloblastic anemia due to folate deficiency,

· seizures or epilepsy,

· kidney malady, or

· liver disease.

• You may not be able to take pyrimethamine, or you may require a dosage adjustment or particular monitoring during treatment if you have any of the conditions listed above.

• Pyrimethamine is in the FDA pregnancy category C. This means that it is not known whether pyrimethamine will be deleterious to an unborn child. Do not take pyrimethamine without first talking to your doctor if you are pregnant or could become pregnant during treatment.

• Pyrimethamine passes into breast milk and may be deleterious to a nursing infant. Do not take pyrimethamine without first talking to your doctor if you are breast-feeding a baby.

How must I take pyrimethamine?

• Take pyrimethamine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

• Take every doze with a full glass of water.

• Take pyrimethamine with food to lessen stomach upset.

• Store pyrimethamine at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. However, if it is nearly time for the following doze, skip the missed doze and only take the following regularly scheduled doze. Do not take a double doze of the medication.

What happens if I overdose?

• Search abnormal medical attention.

• Symptoms of a pyrimethamine overdose may include abdominal pain, nausea, severe vomiting (possibly with blood in the vomit), anxiety or excitability, and seizures.

What must I avoid while taking pyrimethamine?

• There are no restrictions on foods, beverages, or activities during treatment with pyrimethamine unless otherwise directed by your doctor.

What are the possible side effects of pyrimethamine?

• Stop taking pyrimethamine and search abnormal medical attention if you experience an allergic reaction (swelling of the lips, tongue, or person; difficulty breathing; closing of the throat; or hives) during treatment with pyrimethamine.

• Another, smaller serious side effects may be more likely to occur. Continue to take pyrimethamine and conversation to your doctor if you experience

· nausea, vomiting, or loss of appetite;

· insomnia;

· headache;

· lightheadedness; or

· dryness of the mouth.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect pyrimethamine?

• Till taking pyrimethamine, speak your doctor if you are taking any of the next medicines:

· auranofin (Ridaura);

· aurothioglucose (Solganal); or

· or gold sodium thiomalate (Aurolate, Myochrysine).

• You may not be able to take pyrimethamine, or you may require a dosage adjustment or particular monitoring during treatment.

• Drugs another than those listed here may also interact with pyrimethamine. Conversation to your doctor and pharmacist till taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

• Your pharmacist can provide more information about pyrimethamine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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