QUININE

(KWYE nine) Brand: Qualaquin

What is the most significant information I must know about quinine?

• Quinine can reason serious side effects on your heart, kidneys, or blood cells. Stop taking this medication and call your doctor at once if you have headache with chest pain and severe dizziness, quick or pounding heartbeats, unusual bruising or bleeding (nosebleeds, bleeding gums, purple or red spots under your skin), signs of infection (fever, chills, mouth sores), severe lower back pain, or blood in your urine.

• You must not take quinine if you have a heart rhythm mess called Long QT syndrome, a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G-6-PD), myasthenia gravis, optic neuritis (inflammation of the nerves in your eyes), if you have taken quinine in the past and it caused a blood cell mess or severe bleeding.

• Some people have used quinine to treat leg cramps, but this is not an FDA-approved use. Using this medicine improperly or without the advice of a doctor can result in serious side effects or death.

What is quinine?

• The U.S. Food and Drug Administration has banned the sale of all non-approved brands of quinine. Do not purchase quinine on the Internet or from vendors external of the United States.

• Quinine is used to treat uncomplicated malaria, a malady caused by parasites. Parasites that reason malaria typically enter the body through the bite of a mosquito. Malaria is general in areas such as Africa, South America, and Southern Asia.

• Quinine will not treat severe forms of malaria, and it should not be taken to prevent malaria.

• Quinine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking quinine?

• You must not use this medicine if you have ever had an allergic reaction to quinine or similar medicines such as mefloquine or quinidine, or if you have:

· a heart rhythm mess called Long QT syndrome;

· an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G-6-PD);

· myasthenia gravis;

· optic neuritis (inflammation of the optic nerve); or

· if you have taken quinine in the past and it caused a blood cell mess, severe bleeding, or kidney problems.

• To create certain quinine is safety for you, speak your doctor if you have:

· heart malady or a heart rhythm disorder;

· low levels of platelets in your blood;

· low potassium levels in your blood (hypokalemia); or

· liver or kidney disease.

• FDA pregnancy category C. It is not known whether quinine will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• Quinine can pass into breast milk and may harm a nursing child. Speak your doctor if you are breast-feeding a baby.

• Do not give this medicine to a baby younger than 16 years old.

How must I take quinine?

• Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• Take with food if quinine upsets your stomach.

• Take this medicine for the full predesigned length of time. Your symptoms may get better till your condition is completely cleared.

• If you need surgery or medical trials, speak your caregivers onward of time that you are using quinine. You may need to stop using the medication for a short time.

• Call your doctor if your symptoms do not improve after 2 days of treatment, or if your symptoms return after you have finished the medication.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. If you are more than 4 hours late for your doze, skip the missed doze and take the medication at your following scheduled doze time. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking quinine?

• Avoid taking another anti-malaria medications without your doctor's advice. This includes chloroquine, halofantrine, and mefloquine.

• Avoid using antacids without your doctor's advice. Use only the type of antacid your doctor recommends. Some antacids can create it harder for your body to absorb quinine.

• Quinine may reason blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

• Do not use quinine to treat any condition that has not been checked by your doctor.

What are the possible side effects of quinine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have:

· fever, chills, body aches, flu symptoms, sores in your mouth and throat;

· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

· headache with chest pain and severe dizziness, fainting, quick or pounding heartbeats;

· sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with balance;

· chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;

· problems with vision or hearing;

· pain, swelling, warmth, or redness in one or both legs;

· severe pain in your side or lower back, blood in your urine, few or no urine;

· low blood sugar (more general in pregnant women)--headache, famine, weakness, sweating, confusion, irritability, dizziness, quick heart course, or feeling jittery;

· loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• General side effects may include:

· headache, blurred vision, changes in color vision;

· sweating or flushing (warmth, redness, or tingly feeling);

· mild dizziness, spinning sensation, ringing in your ears; or

· upset stomach, vomiting, stomach pain.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect quinine?

• Much drugs can interact with quinine. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with quinine, especially:

· acetazolamide, sodium bicarbonate;

· aminophylline, theophylline;

· arsenic trioxide, vandetanib;

· bosentan;

· imatinib;

· methadone;

· tacrolimus;

· St. John's wort;

· an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine, telithromycin, tetracycline;

· an antidepressant--amitriptyline, citalopram, clomipramine, desipramine, nefazodone, venlafaxine;

· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

· cholesterol-lowering medicine--atorvastatin, simvastatin, lovastatin;

· cough medication that contains dextromethorphan;

· heart medication--amiodarone, digoxin, dofetilide, disopyramide, dronedarone, flecainide, ibutilide, metoprolol, procainamide, propafenone, quinidine, sotalol, verapamil;

· hepatitis C medications--boceprevir, telaprevir;

· HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;

· medication to prevent or treat nausea and vomiting--dolasetron, droperidol, ondansetron;

· medication to treat a psychiatric disorder--chlorpromazine, clozapine, haloperidol, mesoridazine, pimozide, thioridazine, ziprasidone;

· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone;

· stomach acid reducers--cimetidine, ranitidine; or

· tuberculosis medication--rifabutin, rifampin, rifapentine.

• This list is not complete and much another drugs can interact with quinine. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about quinine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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