CLOMIPRAMINE

(kloe MI pra meen) Brand: Anafranil

What is the most significant information I must know about clomipramine?

• You must not take this medicine if you are being treated with methylene blue injection.

• Do not use clomipramine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

• Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using clomipramine. Your family or another caregivers must also be alert to changes in your mood or symptoms.

• Message any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

What is clomipramine?

• Clomipramine is a tricyclic antidepressant. It affects chemicals in the brain that may become unbalanced.

• Clomipramine is used to treat symptoms of obsessive-compulsive mess (OCD) such as recurrent thoughts or feelings and repetitive actions.

• Clomipramine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking clomipramine?

• You must not take this medicine if you are allergic to clomipramine or to similar antidepressants such as amitriptyline, amoxapine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, or trimipramine. You must not take clomipramine if you are being treated with methylene blue injection.

• To create certain clomipramine is safety for you, speak your doctor if you have any of these conditions:

· liver disease;

· kidney disease;

· bipolar mess (manic-depression), schizophrenia or another mental illness;

· history of alcoholism;

· history of seizures or head injury;

· heart disease;

· low blood pressure;

· glaucoma;

· overactive thyroid or adrenal gland tumor (pheochromocytoma or neuroblastoma); or

· urination problems.

• FDA pregnancy category C. It is not known whether clomipramine will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• Clomipramine can pass into breast milk and may harm a nursing child. You must not breast-feed while you are using this medication.

• Do not give clomipramine to anyone younger than 18 years old without the advice of a doctor.

How must I take clomipramine?

• Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.

• Take clomipramine with food to reduce stomach upset.

• It may take up to 4 weeks till your symptoms improve. Hold using the medicine as directed and speak your doctor if your symptoms do not improve after 4 weeks of treatment.

• If you need surgery, speak the surgeon onward of time that you are using clomipramine. You may need to stop using the medication for a short time.

• Do not stop using clomipramine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using clomipramine.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of clomipramine can be fatal.

• Overdose symptoms may include vomiting, quick or uneven heart course, loss of balance or coordination, extreme drowsiness, fever, severe sweating, stiff muscles, heighten or decreased urination, blue lips or fingernails, weak or shallow breathing, fainting, seizure (convulsions) or coma.

What must I avoid while taking clomipramine?

• Avoid drinking alcohol. It can reason dangerous side effects when taken together with clomipramine.

• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of clomipramine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

• Call your doctor at once if you have:

· rapid heart course, tremors or shaking;

· confusion, extreme fear, thoughts of hurting yourself;

· agitation, hallucinations, fever, overactive reflexes, vomiting, diarrhea, loss of coordination, fainting;

· painful or difficult urination;

· very stiff (rigid) muscles;

· seizure (convulsions), or

· weary feeling, weakness, light bruising or bleeding (nosebleed, bleeding gums), pale skin, feeling light-headed or short of breath.

• General side effects may include:

· dry mouth, nausea, upset stomach, loss of appetite, constipation;

· feeling anxious, restless, dizzy, drowsy, or tired;

· sleep problems (insomnia);

· appetite or weight changes;

· memory problems, trouble concentrating;

· heighten sweating, numbness or tingling;

· vision changes; or

· decreased sex drive, impotence, or difficulty having an orgasm.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect clomipramine?

• Taking clomipramine with another drugs that create you sleepy or slow your breathing can magnify these effects. Ask your doctor till taking clomipramine with a sleeping pill, narcotic pain medication, muscle relaxer, or medication for anxiety, depression, or seizures.

• Till taking clomipramine, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine (Paxil), sertraline (Zoloft), trazodone, or vilazodone (Viibryd).

• Much drugs can interact with clomipramine. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with clomipramine, especially:

· bupropion;

· cimetidine;

· phenytoin;

· St. John's wort;

· anti-malaria medication;

· a barbiturate such as phenobarbital or secobarbital;

· bladder or urinary medicines such as darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin;

· bronchodilators such as ipratropium or tiotropium;

· cool or allergy medication, stimulants, or ADHD medication;

· cough medication that contains dextromethorphan;

· heart or blood pressure medication;

· medicine to treat an infection caused by fungus;

· medicine to treat HIV or AIDS;

· medicine to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel disease;

· medicine for Parkinson's malady, such as ropinirole (Requip);

· medication to treat depression or mental diseases; or

· thyroid medication.

• This list is not complete and much another drugs can interact with clomipramine. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about clomipramine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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