FLUCONAZOLE

(floo KOE na zole) Brand: Diflucan

What is the most significant information I must know about fluconazole?

• Do not use this medicine if you are allergic to fluconazole, or similar drugs such as clotrimazole (Lotrimin), econazole (Spectazole), ketoconazole (Nizoral), miconazole (Monistat, Oravig), sertaconazole (Ertaczo), sulconazole (Exelderm), terconazole (Terazol), tioconazole (Vagistat-1), or voriconazole (Vfend).

• You must not use fluconazole if you are also taking cisapride (Propulsid).

• Till taking fluconazole, speak your doctor if you have liver malady, kidney malady, a heart rhythm mess, or a history of Long QT syndrome.

• Take this medicine for the full predesigned length of time. Your symptoms may improve till the infection is completely cleared. Skipping doses may also magnify your risk of further infection that is resistant to antifungal medicine. Fluconazole will not treat a viral infection such as the general cool or flu.

What is fluconazole?

• Fluconazole is an antifungal antibiotic.

• Fluconazole is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, genital area, and the blood.

• Fluconazole is also used to prevent fungal infection in people with weak immune systems caused by cancer treatment, bone marrow transplant, or illness such as AIDS.

• Fluconazole may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking fluconazole?

• You must not use fluconazole if you are also taking cisapride (Propulsid).

• To create certain you can safely take fluconazole, speak your doctor if you have any of these another conditions:

· liver disease;

· kidney disease;

· a heart rhythm mess; or

· a private or family history of Long QT syndrome.

• FDA pregnancy category D. Do not take more than 1 doze of fluconazole if you are pregnant. Long-term use of fluconazole can harm an unborn child or reason birth defects. Use effective birth control, and speak your doctor if you become pregnant during treatment.

• A single doze of fluconazole taken to treat a vaginal yeast infection is not expected to harm an unborn baby.

• Fluconazole can pass into breast milk and may harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take fluconazole?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Your doze will depend on the infection you are treating. Vaginal infections are often treated with only one pill. For another infections, your first doze may be a double doze. Carefully follow your doctor's instructions. Speak your doctor if your symptoms do not improve.

• Take this medication with a full glass of water.

• Shake the oral suspension (liquid) well just till you measure a doze. To be certain you get the correct doze, measure the liquid with a marked measuring spoon or medication cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• Store fluconazole tablets at room temperature away from moisture and heat.

• You may store liquid fluconazole in a refrigerator, but do not let it to freeze. Throw away any leftover liquid medication that is more than 2 weeks old.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include confusion or unusual thoughts or behavior.

What must I avoid while taking fluconazole?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of fluconazole?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have any of these serious side effects:

· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· fever, chills, body aches, flu symptoms;

· severe blistering, peeling, and red skin rash;

· light bruising or bleeding, unusual weakness; or

· seizure (convulsions).

• Smaller serious side effects may include:

· mild stomach pain, diarrhea, upset stomach;

· headache;

· dizziness; or

· unusual or unpleasant taste in your mouth.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect fluconazole?

• Speak your doctor about all another medicines you use, especially:

· a blood thinner such as warfarin (Coumadin, Jantoven);

· alfentanil (Alfenta), fentanyl (Abstral, Actiq, Fentora, Duragesic, Ionsys, Lazanda, Onsolis);

· clopidogrel (Plavix);

· cyclophosphamide (Cytoxan, Neosar);

· cyclosporine (Gengraf, Sandimmune, Neoral);

· methadone (Diskets, Dolophine, Methadose);

· pimozide (Orap);

· prednisone (Deltasone, Sterapred);

· saquinavir (Invirase) or zidovudine (Retrovir, Trizivir);

· sirolimus (Rapamune) or tacrolimus (Prograf);

· theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl, others);

· voriconazole (Vfend);

· an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol) or nortriptyline (Pamelor);

· cancer medication such as vinorelbine (Navelbine), vincristine (Oncovin, Vincasar), or vinblastine (Velban);

· cholesterol lowering medicines such as atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin);

· heart or blood pressure medication such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), felodipine (Plendil), isradipine (Dynacirc), losartan (Cozaar, Hyzaar), or nifedipine (Nifedical, Procardia);

· NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

· oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), tolbutamide (Orinase), tolazamide (Tolinase), chlorpropamide (Diabinese), and others;

· rifabutin (Mycobutin) or rifampin (Rifadin, Rifater, Rifamate, Rimactane);

· a sedative such as diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), midazolam (Versed), or triazolam (Halcion); or

· seizure medicine such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin) or valproic acid (Depakene).

• This list is not complete and another drugs may interact with fluconazole. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about fluconazole.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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