TADALAFIL

(ta DAL a fil) Brand: Adcirca, Cialis

What is the most significant information I must know about tadalafil?

• You must not use tadalafil if you are allergic to it.

• Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking tadalafil with a nitrate medication can reason a sudden and serious decrease in blood pressure.

• Contact your doctor or search abnormal medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can hurt the penis.

• Stop using tadalafil and get abnormal medical help if you have sudden vision loss.

What is tadalafil?

• Tadalafil relaxes muscles and increases blood flow to special areas of the body.

• Tadalafil under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Other brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercice ability in men and women.

• Do not take Cialis while also taking Adcirca, unless your doctor tells you to.

• Tadalafil may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking tadalafil?

• You must not take tadalafil if you are allergic to it.

• Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking tadalafil with a nitrate medication can reason a sudden and serious decrease in blood pressure.

• To create certain tadalafil is safety for you, speak your doctor if you have any of these another conditions:

· heart malady or heart rhythm problems, coronary artery disease;

· a last heart onslaught (within the past 90 days);

· a last history (in the past 6 months) of a stroke, or congestive heart failure;

· angina (chest pain), tall or low blood pressure;

· liver or kidney malady (or if you are on dialysis);

· a blood cell mess such as sickle cell anemia, multiple myeloma, or leukemia;

· a bleeding mess such as hemophilia;

· a stomach ulcer;

· retinitis pigmentosa (an inherited condition of the eye);

· a physical deformity of the penis (such as Peyronie's disease); or

· if you have been told you must not have sexual intercourse for health reasons.

• Tadalafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a little number of people taking tadalafil, most of whom also had heart malady, diabetes, tall blood pressure, tall cholesterol, or determined pre-existing eye problems, and in those who smoke or are over 50 years old. Stop using tadalafil and get abnormal medical help if you have sudden vision loss.

• FDA pregnancy category B. Tadalafil is not expected to harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment with Adcirca.

• It is not known whether tadalafil passes into breast milk or if it could harm a nursing child. Speak your doctor if you are breast-feeding a baby.

How must I take tadalafil?

• Tadalafil is generally taken only once for day. Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• Tadalafil can be taken with or without food.

• For erectile dysfunction, take Cialis just till sexual activity but not more than once for day.

• Cialis can help attain an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions.

• During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of tadalafil.

• Do not interrupt or split a Cialis tablet. Swallow it intact.

• Do not take Cialis for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• If tadalafil is used as needed, you are not likely to be on a dosing schedule.

• If you take tadalafil each day and you miss a doze, take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking tadalafil?

• Grapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit commodity while taking this medicine.

• Drinking alcohol can magnify determined side effects of tadalafil.

• Avoid using any another medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor.

What are the possible side effects of tadalafil?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Contact your doctor or search abnormal medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can hurt the penis.

• Stop using tadalafil and call your doctor at once if you have:

· vision changes or sudden vision loss;

· ringing in your ears, or sudden hearing loss;

· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling;

· irregular heartbeat;

· swelling in your hands, ankles, or feet;

· shortness of breath;

· seizure (convulsions); or

· a light-headed feeling, like you might pass out.

• General side effects may include:

· headache;

· redness or warmth in your person, neck, or chest;

· cool symptoms such as stuffy nose, sinus pain, sore throat, cough;

· upset stomach; or

· muscle pain, back pain, pain in your arms or legs.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect tadalafil?

• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with tadalafil, especially:

· bosentan;

· imatinib;

· nefazodone;

· St. John's wort;

· an antibiotic--clarithromycin, erythromycin, telithromycin;

· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

· heart or blood pressure medication--amlodipine nicardipine, quinidine;

· hepatitis C medications--boceprevir, telaprevir;

· HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;

· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or

· tuberculosis medication--isoniazid, rifabutin, rifampin, rifapentine.

• This list is not complete. Another drugs may interact with tadalafil, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Not all possible interactions are listed in this medicine manual.

Where can I get more information?

• Your pharmacist can provide more information about tadalafil.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.