PROMETHAZINE (ORAL)

(pro METH a zeen) Brand: Pentazine, Phenergan

What is the most significant information I must know about oral promethazine?

• Stop using this medicine and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, person, arms, or legs. These could be early signs of dangerous side effects.

• Promethazine must not be given to a baby younger than 2 years old. Promethazine can reason severe breathing problems or death in a baby younger than 2. Carefully follow your doctor's instructions when giving this medication to a baby of any age.

• Promethazine can reason side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

• Avoid drinking alcohol, which can magnify some of the side effects of promethazine.

• There are much another medicines that can interact with promethazine. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor. Hold a list with you of all the medicines you use and show this list to any doctor or another healthcare provider who treats you.

What is oral promethazine?

• Promethazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain. Promethazine also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.

• Promethazine is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

• Promethazine also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.

• Promethazine is not for use in treating symptoms of asthma, pneumonia, or another lower respiratory tract infections.

• Promethazine may also be used for another purposes not listed in this medicine guide.

What must I discuss with my doctor till taking oral promethazine?

• Do not use this medicine if you have severe asthma, emphysema, or another breathing problem, or if you are allergic to promethazine or another phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Permitil), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), thioridazine (Mellaril), or trifluoperazine (Stelazine).

• If you have determined conditions, you may need a doze adjustment or particular trials to safely use this medicine. Till you take promethazine, speak your doctor if you have:

· a history of seizures;

· heart malady or tall blood pressure;

· liver or kidney disease;

· severe asthma, emphysema, chronic obstructive pulmonary malady (COPD) or another breathing problem;

· sleep apnea (breathing stops during sleep);

· glaucoma;

· a stomach ulcer or digestive obstruction;

· bone marrow depression;

· adrenal gland tumor (pheochromocytoma);

· enlarged prostate or problems with urination;

· low levels of calcium in your blood (hypocalcemia); or

· if you have ever had a serious side effect while using promethazine or any another phenothiazine.

• FDA pregnancy category C. It is not known whether promethazine is deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether promethazine passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Older adults may be more likely to have side effects from this medication.

How must I take oral promethazine?

• Take this medicine exactly as predesigned by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze to create certain you get the excellent results from this medication.

• Promethazine can be taken with or without food or milk.

• Measure liquid medication with a marked measuring spoon or medication cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• Call your doctor if your symptoms do not improve, or if they get worse while taking promethazine.

• This medicine can reason you to have unusual results with determined medical trials. Speak any doctor who treats you that you are using promethazine.

• Store this medicine at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. If it is nearly time for your following doze, skip the missed doze and take the medication at the following regularly scheduled time. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medication. Overdose symptoms may include severe drowsiness, dizziness, dry mouth, big pupils, flushing, nausea, vomiting, shallow breathing, and fainting.

What must I avoid while taking oral promethazine?

• Promethazine can reason side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

• Avoid drinking alcohol. It can magnify some of the side effects of promethazine.

• Avoid exposure to sunlight or tanning beds. Promethazine can create your skin more sensitive to sunlight, and a sunburn may result. Wear sunscreen (SPF 15 or higher) and protective clothing if you should be outdoors.

What are the possible side effects of oral promethazine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using promethazine and call your doctor at once if you have any of these serious side effects:

· twitching, or uncontrollable movements of your eyes, lips, tongue, person, arms, or legs;

· tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;

· feeling restless, jittery, or agitated;

· tall fever, stiff muscles, confusion, sweating, quick or uneven heartbeats, rapid breathing;

· feeling like you might pass out;

· seizure (convulsions);

· pale skin, light bruising or bleeding, fever, sore throat, flu symptoms;

· decreased night vision, tunnel vision, watery eyes, heighten sensitivity to light;

· hallucinations, agitation;

· nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);

· urinating smaller than normal or not at all;

· joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or

· slow heart course, weak pulse, fainting, slow breathing (breathing may stop).

• Smaller serious side effects may include:

· dizziness, drowsiness, anxiety;

· blurred vision, dry mouth, stuffy nose;

· ringing in your ears;

· weight gain, swelling in your hands or feet;

· impotence, trouble having an orgasm; or

· constipation.

• This is not a complete list of side effects and others may occur. Speak your doctor about any unusual or bothersome side effect. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect oral promethazine?

• Cool or allergy medication, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression or anxiety can interact with promethazine and reason medical problems or magnify side effects. Speak your doctor if you regularly use any of these medicines.

• Also speak your doctor if you are using any of the next medicines:

· lithium (Eskalith, Lithobid);

· atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

· blood pressure medicine such as guanadrel (Hylorel), guanethidine (Ismelin), propranolol (Inderal), and others;

· a blood thinner such as warfarin (Coumadin);

· bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

· bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), and others;

· an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam); or

· medicines to treat Parkinson's malady, restless leg syndrome, or pituitary gland tumor (prolactinoma); or

· medication to treat stomach ulcer or irritable bowel syndrome, such as dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), mepenzolate (Cantil), or propantheline (Pro-Banthine).

• This list is not complete and there are much another medicines that can interact with promethazine. Speak your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start a new medicine without telling your doctor. Hold a list with you of all the medicines you use and show this list to any doctor or another healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about oral promethazine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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