DOXEPIN (SINEQUAN)

(DOX e pin) Brand: SINEquan

What is the most significant information I must know about doxepin (Sinequan)?

• You must not take doxepin if you have glaucoma or problems with urination. Do not use if you are allergic to doxepin or to similar medications such as amitriptyline, amoxapine, clomipramine, desipramine, imipramine, nortriptyline, protriptyline, or trimipramine.

• Do not use doxepin if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

• Message any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

What is doxepin (Sinequan)?

• Doxepin is a tricyclic antidepressants. Doxepin affects chemicals in the brain that may become unbalanced.

• Doxepin (Sinequan or another generic name) is used to treat symptoms of depression and/or anxiety associated with alcoholism, psychiatric conditions, or manic-depressive conditions.

• Doxepin may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking doxepin (Sinequan)?

• To create certain doxepin is safety for you, speak your doctor if you have:

· sleep apnea (breathing stops during sleep);

· diabetes (doxepin may raise or lower blood sugar); or

· bipolar mess (manic-depression).

• Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using doxepin. Your family or another caregivers must also be alert to changes in your mood or symptoms.

• FDA pregnancy category C. It is not known whether doxepin will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether doxepin passes into breast milk or if it could harm a nursing child. Speak your doctor if you are breast-feeding a baby.

• Do not give this medication to a baby without medical advice.

How must I take doxepin (Sinequan)?

• Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.

• Measure doxepin oral concentrate (liquid) with the particular dose-measuring dropper provided. Do not use a regular table spoon. If you do not have a dose-measuring dropper, ask your pharmacist for one.

• Empty the measured doze from the medication dropper into a little glass (4 ounces) of water, milk, orange juice, grapefruit juice, tomato juice, prune juice, or pineapple juice. Do not use grape juice or a carbonated soft drink to mix doxepin oral concentrate. Stir the mixture and drink all of it right away. Do not save it for later use.

• It may take 2 to 3 weeks till your depression symptoms improve. Hold using the medicine as directed and speak your doctor if your symptoms do not improve.

• Do not stop using doxepin suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using doxepin.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of doxepin can be fatal.

What must I avoid while taking doxepin (Sinequan)?

• Do not drink alcohol. Doxepin can magnify the effects of alcohol, which could be dangerous.

• Doxepin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of doxepin (Sinequan)?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have:

· quick heart rate;

· skin rash, bruising, severe tingling, numbness, pain, muscle weakness;

· feeling like you might pass out;

· tremors, restless muscle movements in your eyes, tongue, jaw, or neck;

· confusion, hallucinations, unusual thoughts, seizure (convulsions); or

· painful or difficult urination, urinating smaller than usual.

• Another general side effects may include:

· feeling dizzy, drowsy, or tired;

· nausea, vomiting, constipation;

· dry mouth, blurred vision, ringing in your ears;

· weight gain, heighten sweating;

· breast swelling (in men or women); or

· decreased sex drive.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect doxepin (Sinequan)?

• Taking doxepin with another drugs that create you sleepy or slow your breathing can magnify these effects. Ask your doctor till taking doxepin with a sleeping pill, narcotic pain medication, muscle relaxer, or medication for anxiety, depression, or seizures.

• Till taking doxepin, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, or sertraline.

• You should wait at least 5 weeks after stopping fluoxetine (Prozac) till you can take doxepin.

• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with doxepin, especially:

· bupropion;

· cimetidine (Tagamet);

· St. John's wort;

· terbinafine;

· tolazamide (Tolinase);

· any another anti-depressant, or medicine to treat mental diseases; or

· the heart rhythm medications flecainide, propafenone, or quinidine.

• This list is not complete and much another drugs can interact with doxepin. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about doxepin (Sinequan).

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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