APREPITANT

(a PREP i tant) Brand: Emend, Emend 2-Day, Emend 3-Day

What is the most significant information I must know about aprepitant?

• Do not take aprepitant if you are taking any of the next drugs: cisapride (Propulsid) or pimozide (Orap). These drugs may reason life-threatening interactions when taken together with aprepitant.

• If you have liver malady, you may need an aprepitant doze adjustment or particular tests.

• Aprepitant can create birth control pills smaller effective, resulting in pregnancy. This effect can recent for up to 28 days after your recent doze of this medicine. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking aprepitant and for at least 1 month after your treatment ends.

• There are much another drugs that can interact with aprepitant. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

What is aprepitant?

• Aprepitant blocks the actions of chemicals in the body that trigger nausea and vomiting.

• Aprepitant is used together with another medications to prevent nausea and vomiting that may be caused by surgery or cancer chemotherapy.

• Aprepitant is given onward of time and will not treat nausea or vomiting that you already have.

• Aprepitant may also be used for another purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking aprepitant?

• You must not use aprepitant if you are allergic to it.

• These another drugs can reason serious or life-threatening medical problems if you take them together with aprepitant:

· cisapride (Propulsid); or

· pimozide (Orap).

• If you have liver malady, you may need an aprepitant doze adjustment or particular tests.

• FDA pregnancy category B. Aprepitant is not expected to be deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether aprepitant passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take aprepitant?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Aprepitant can be taken with or without food. If you take aprepitant till surgery, follow your doctor's instructions about any restrictions on food or beverages.

• The first doze of aprepitant is generally taken 1 hour till treatment with chemotherapy, or 3 hours till a surgery. You may also need additional doses for a couple days after your chemotherapy treatment. Follow your doctor's instructions.

• You may also be given another medicines with aprepitant to further help prevent nausea and vomiting.

• Aprepitant is not for long-term use.

• This medicine comes with patient instructions for safety and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Call your doctor for instructions if you forget to take your medication within the predesigned length of time till your chemotherapy or surgery.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include drowsiness and headache.

What must I avoid while taking aprepitant?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of aprepitant?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· feeling like you might pass out;

· feeling very thirsty or hot, being unable to urinate, hard sweating, or hot and dry skin; or

· fever, chills, body aches, flu symptoms, sores in your mouth and throat.

• Smaller serious side effects may include:

· nausea, vomiting, heartburn, stomach pain;

· diarrhea or constipation;

· loss of appetite;

· hiccups;

· hair loss;

· headache;

· dizziness;

· weary feeling;

· mild skin rash;

· ringing in your ears; or

· sleep problems (insomnia).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect aprepitant?

• Speak your doctor about all another medicines you use, especially:

· tolbutamide (Orinase);

· a blood thinner such as warfarin (Coumadin);

· midazolam (Versed) or similar medicines such as Valium, Xanax, or Tranxene;

· an antidepressant such as nefazodone (Serzone) or paroxetine (Paxil);

· an antibiotic such as clarithromycin (Biaxin) or rifampin (Rifater, Rifamate);

· an antifungal medicine such as itraconazole (Sporanox) or ketoconazole (Extina, Ketozole, Nizoral, Xolegal);

· determined cancer medicines such as ifosfamide (Ifex), vinblastine (Velban), or vincristine (Oncovin, Vincasar);

· HIV medicines such as nelfinavir (Viracept), lopinavir/ritonavir (Kaletra), or ritonavir (Norvir);

· seizure medicine such as carbamazepine (Tegretol, Carbatrol) or phenytoin (Dilantin); or

· steroid medication such as dexamethasone (Decadron, Hexadrol) or methylprednisolone (Medapred, Solu-Medrol).

• There are much another drugs that may interact with aprepitant. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about aprepitant.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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