BUPROPION

(byoo PRO pee on) Brand: Aplenzin, Budeprion SR, Buproban, Forfivo XL, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Winning Pack

What is the most significant information I must know about bupropion?

• Do not use bupropion if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

• You must not take bupropion if you have seizures, an eating mess, or if you have suddenly stopped using alcohol, seizure medicine, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.

• Bupropion may reason seizures, especially in people with determined medical conditions or when using determined drugs. Speak your doctor about all of your medical conditions and the drugs you use.

• Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using bupropion. Your family or another caregivers must also be alert to changes in your mood or symptoms.

• Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

What is bupropion?

• Bupropion is an antidepressant medicine used to treat major depressive mess and seasonal affective mess. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and another withdrawal effects.

• Bupropion may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking bupropion?

• You must not take bupropion if you are allergic to it, or if you have:

· epilepsy or a seizure disorder;

· an eating mess such as anorexia or bulimia; or

· if you have suddenly stopped using alcohol, seizure medicine, or a sedative (Valium, Nembutal, Seconal, Solfoton, and others).

• Bupropion may reason seizures, especially in people with determined medical conditions. Speak your doctor about all of your medical conditions.

• Do not take bupropion to treat more than one condition at a time. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.

• To create certain bupropion is safety for you, speak your doctor if you have:

· a history of head injury, seizures, or brain or spinal cord tumor;

· heart malady, tall blood pressure, history of heart attack;

· kidney or liver malady (especially cirrhosis); or

· bipolar mess (manic depression).

• FDA pregnancy category C. It is not known whether bupropion will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• Bupropion can pass into breast milk and may harm a nursing child. You must not breast-feed while using this medicine.

How must I take bupropion?

• Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended. Too many of this medication can magnify your risk of a seizure.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact.

• If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medication. Set a date to quit smoking during the second week of treatment. Conversation to your doctor if you are having trouble quitting after you have used Zyban for at least 7 weeks.

• Your doctor may prescribe nicotine patches or gum to help support your smoking cessation treatment. Read all directions and safe information for the nicotine product. Do not smoke at any time if you are using a nicotine product along with Zyban. Too many nicotine can reason serious side effects.

• Do not stop using bupropion suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using bupropion.

• This medicine can reason you to have a false positive drug screening test. If you provide a urine sample for drug screening, speak the laboratory staff that you are taking bupropion.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, quick or uneven heartbeat, shallow breathing, or fainting.

What must I avoid while taking bupropion?

• Drinking alcohol may magnify your risk of seizures. If you drink alcohol regularly, conversation with your doctor till changing the amount you drink. Bupropion can reason seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication.

• Bupropion may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of bupropion?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have:

· seizure (convulsions);

· quick heartbeats;

· fever, swollen glands, rash or itching, joint pain, or common ill feeling;

· confusion, trouble concentrating, hallucinations, unusual thoughts or behavior; or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• Smaller serious side effects may include:

· dry mouth, nausea, stomach pain;

· headache, dizziness, ringing in your ears;

· loss of interest in sex;

· sore throat, muscle pain;

· mild itching or skin rash, heighten sweating, heighten urination; or

· changes in appetite, weight loss or gain.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect bupropion?

• Much drugs can interact with bupropion. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with bupropion, especially:

· medicine used to prevent blood clots, such as clopidogrel, ticlopidine, tirofiban;

· heart or blood pressure medicine such as atenolol, flecainide, metoprolol, propafenone, propranolol, and others;

· HIV or AIDS medications such as efavirenz or ritonavir; or

· seizure medicine such as carbamazepine, phenobarbital, phenytoin.

• This list is not complete and much another drugs can interact with bupropion. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

• You may have a higher risk of seizures if you use determined medications together with bupropion. Tell your doctor about all another medications you use, especially:

· any another antidepressant, or a medication to treat a psychiatric disorder;

· an antibiotic (amoxicillin, cefdinir, cephalexin, ciprofloxacin, penicillin, and others);

· antihistamines that create you sleepy;

· asthma medications or bronchodilators;

· birth control pills or hormone replacement estrogens;

· bladder or urinary medications (oxybutynin, tolterodine, and others);

· diet pills, a stimulant, or ADHD medication;

· insulin or oral diabetes medication;

· medication for nausea, vomiting, or motion sickness;

· medications to treat or prevent malaria;

· medicines to treat Parkinson's malady, restless leg syndrome, or pituitary gland tumor (prolactinoma);

· medicines used to prevent organ transplant rejection;

· narcotic pain medication;

· numbing medication such as lidocaine or Novocain;

· a steroid such as prednisone, and others;

· street drugs such as "speed" or cocaine;

· theophylline; or

· ulcer or irritable bowel medications.

Where can I get more information?

• Your pharmacist can provide more information about bupropion.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(50)