AVANAFIL

(a VAN a fil) Brand: Stendra

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What is the most significant information I must know about avanafil?

• Do not take avanafil if you are allergic to it, or if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin (Nitro Dur, Nitrolingual, Nitrostat, Transderm Nitro, and others), isosorbide dinitrate (Dilatrate, Isordil, Isochron), isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking avanafil with a nitrate medication can reason a sudden and serious decrease in blood pressure.

• If you become dizzy or nauseated during sexual activity, or if you have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of avanafil.

Do not take avanafil more than once a day. Let 24 hours to pass between doses.

• Contact your doctor or search abnormal medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can hurt the penis.

Avanafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a little number of people taking a similar medicine called sildenafil (Viagra). Most of these people also had heart malady, diabetes, tall blood pressure, tall cholesterol, or determined pre-existing eye problems, and in those who smoke or are over 50 years old.

• Stop using avanafil and get abnormal medical help if you have sudden vision loss.

What is avanafil?

Avanafil relaxes muscles and increases blood flow to special areas of the body.

Avanafil is used to treat erectile dysfunction (impotence).

Avanafil may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking avanafil?

• You must not take avanafil if you are allergic to it.

Avanafil must not be used together with nitrate medicine, such as nitroglycerin (Nitro Dur, Nitrolingual, Nitrostat, Transderm Nitro, and others), isosorbide dinitrate (Dilatrate, Isordil, Isochron), isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking avanafil with a nitrate medication for chest pain or heart problems can reason a sudden and serious decrease in blood pressure.

• To create certain you can safely take avanafil, speak your doctor if you have any of these another conditions:

· heart malady or heart rhythm disorder;

· a last history (in the past 6 months) of a heart onslaught, stroke, heart surgery, or life-threatening heart rhythm problem;

· congestive heart failure;

· angina (chest pain), tall or low blood pressure;

· liver disease;

· kidney malady (or if you are on dialysis);

· a blood cell mess such as sickle cell anemia, multiple myeloma, or leukemia;

· a bleeding mess such as hemophilia;

· a stomach ulcer;

· retinitis pigmentosa (an inherited condition of the eye) or a history of vision loss;

· a physical deformity of the penis (such as Peyronie's disease); or

· if you have been told you must not have sexual intercourse for health reasons.

Avanafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a little number of people taking a similar medicine called sildenafil (Viagra). Most of these people also had heart malady, diabetes, tall blood pressure, tall cholesterol, or determined pre-existing eye problems, and in those who smoke or are over 50 years old.

• It is not clear whether avanafil could reason vision loss. Stop using avanafil and get abnormal medical help if you have sudden vision loss.

• FDA pregnancy category C. Avanafil is not for use in women. It is not known whether avanafil will harm an unborn child.

• Although avanafil is not for use in women, it is not known if this medicine passes into breast milk or if it could harm a nursing child.

How must I take avanafil?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze to create certain you get the excellent results.

Avanafil can be taken with or without food.

Avanafil is generally taken only when needed, about 30 minutes till sexual activity. Follow your doctor's instructions.

Avanafil can help attain an erection when sexual stimulation occurs. An erection will not occur just by taking a pill.

Do not take avanafil more than once a day. Let 24 hours to pass between doses.

• Contact your doctor or search abnormal medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can hurt the penis.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Since avanafil is used as needed, you are not likely to be on a dosing schedule.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while taking avanafil?

• Drinking alcohol can magnify determined side effects of avanafil. Avoid drinking more than 3 alcoholic beverages while you are taking avanafil.

• Grapefruit and grapefruit juice may interact with avanafil and lead to potentially dangerous effects. Discuss the use of grapefruit commodity with your doctor.

• Avoid using another medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra) while you are taking avanafil.

• This medicine will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.

What are the possible side effects of avanafil?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• If you become dizzy or nauseated during sexual activity, or if you have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of avanafil.

• Stop using avanafil and call your doctor at once if you have any of these serious side effects:

· changes in vision or sudden vision loss;

· ringing in your ears, or sudden hearing loss;

· chest pain, pounding heartbeats or fluttering in your chest;

· pain, swelling, warmth, or redness in one or both legs;

· shortness of breath, swelling in your hands or feet;

· feeling light-headed, fainting; or

· penis erection that is painful or lasts 4 hours or longer.

• Smaller serious side effects may include:

· redness or warmth in your person, neck, or chest;

· headache, mild dizziness;

· cool symptoms such as stuffy nose, sinus pain, or sore throat;

· diarrhea, constipation, upset stomach; or

· back pain.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect avanafil?

• Speak your doctor about all another medicines you use, especially:

· conivaptan (Vaprisol);

· imatinib (Gleevec);

· isoniazid (for treating tuberculosis);

· nefazodone;

· rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, Rifater, Rifamate), or rifapentine (Priftin);

· an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);

· antifungal medicine such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), posaconazole (Noxafil), or voriconazole (Vfend);

· an antidepressant such as nefazodone;

· a barbiturate such as phenobarbital (Solfoton);

· drugs to treat tall blood pressure or a prostate mess, such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), silodosin (Rapaflo), or tamsulosin (Flomax, Jalyn);

· heart or blood pressure medicine such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), diltiazem (Cardizem, Cartia, Dilacor, Diltia, Diltzac, Taztia, Tiazac), enalapril (Vasotec), nicardipine (Cardene), nifedipine (Nifedical, Procardia), quinidine (Quin-G), verapamil (Calan, Covera, Isoptin, Verelan, Tarka), and others;

· HIV or AIDS medications such as atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), nevirapine (Viramune), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), or saquinavir (Invirase);

· seizure medications such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), and others; or

· the hepatitis C medications boceprevir (Victrelis) or telaprevir (Incivek).

• This list is not complete and another drugs may interact with avanafil. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about avanafil.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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