ISOSORBIDE DINITRATE

(EYE soe SOR bide paint NYE trate) Brand: Dilatrate-SR, Isochron, Isordil Titradose

What is the most significant information I must know about isosorbide dinitrate?

• Do not use isosorbide dinitrate if you are taking sildenafil (Viagra). Serious, life-threatening side effects can occur if you take isosorbide dinitrate while you are using sildenafil.

• You must not use this medicine if you are allergic to isosorbide dinitrate, isosorbide mononitrate (Imdur, ISMO, Monoket), or nitroglycerin, or if you have early signs of a heart onslaught (chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling).

• Till taking isosorbide dinitrate, speak your doctor if you have congestive heart failure, low blood pressure, or kidney disease.

• Isosorbide dinitrate can reason severe headaches, especially when you first start using it. These headaches may gradually become smaller severe as you continue to use the medicine. Do not stop taking isosorbide dinitrate. Ask your doctor till using any headache pain medication.

• Only the sublingual tablet must be used to treat an angina onslaught that has already begun.

• Isosorbide dinitrate regular and extended-release tablets are used to prevent angina attacks but will not treat an angina attack.

• It is significant to hold taking this medication as directed to prevent an angina onslaught. Get your prescription refilled till you run out of medication completely.

• Do not stop taking isosorbide dinitrate suddenly. Stopping suddenly could reason a severe angina attack.

What is isosorbide dinitrate?

• Isosorbide dinitrate is in a group of drugs called nitrates. Isosorbide dinitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

• Isosorbide dinitrate is used to treat or prevent attacks of chest pain (angina).

• Only the sublingual tablet must be used to treat an angina onslaught that has already begun.

• Isosorbide dinitrate regular and extended-release tablets are used to prevent angina attacks but will not treat an angina attack.

• Isosorbide dinitrate may also be used for purposes another than those listed in this medicine guide.

What must I discuss with my healthcare provider till taking isosorbide dinitrate?

• If you have any of these another conditions, you may need a doze adjustment or particular trials to safely take isosorbide dinitrate:

· congestive heart failure;

· low blood pressure; or

· kidney disease.

• FDA pregnancy category C. It is not known whether isosorbide dinitrate is deleterious to an unborn child. Till you take this medicine, speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether isosorbide dinitrate passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Isosorbide dinitrate can reason severe headaches, especially when you first start using it. These headaches may gradually become smaller severe as you continue to use isosorbide dinitrate. Do not stop taking the medicine. Ask your doctor till using any headache pain medication.

How must I take isosorbide dinitrate?

• Take this medicine exactly as predesigned by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

• Your doctor may occasionally change your doze to create certain you get the excellent results from this medicine. Isosorbide dinitrate is generally taken 2 or 3 times for day. Follow your doctor's dosing instructions very carefully.

• If possible, try to rest or remain seated when you use this medicine. Isosorbide dinitrate can reason dizziness or fainting.

• Do not crush, chew, interrupt, or open an extended-release tablet or capsule. Swallow the pill intact. Breaking the pill may reason too many of the drug to be released at one time.

• If you suppose to engage in an activity that may reason angina, take the sublingual tablet about 15 minutes till the activity.

• If you use the sublingual tablet to treat an angina onslaught that has already begun, use the medication at the first sign of chest pain. Seat the tablet under your tongue and let it to dissolve slowly. Do not chew or swallow it.

• Till using isosorbide dinitrate to treat a sudden angina onslaught, your doctor may want you to first use a nitroglycerin sublingual tablet. Follow your doctor's instructions about what medications to use during an onslaught and how many time to let between doses.

• Some things can reason your blood pressure to get too low. This includes vomiting, diarrhea, hard sweating, heart malady, dialysis, a low-salt diet, or taking diuretics (water pills). Speak your doctor if you have a prolonged diseases that causes diarrhea or vomiting.

• Search abnormal medical attention if your chest pain gets worse or lasts more than 5 minutes, especially if you have trouble breathing or feel weak, dizzy, or nauseated, or lightheaded.

• It is significant to hold this medication on arm at all times in case of an angina onslaught. Get your prescription refilled till you run out of medication completely.

• If you take isosorbide dinitrate on a regular schedule to prevent angina, do not stop taking it suddenly or you could have a severe onslaught of angina.

• Do not change brands of isosorbide dinitrate without the approval of your doctor.

• Store isosorbide dinitrate at room temperature, away from moisture, heat, and easy. Hold the bottle tightly closed when not in use.

What happens if I miss a dose?

• Since isosorbide dinitrate is sometimes used only when needed, you may not be on a dosing schedule. If you are using the medicine regularly, use the missed doze as soon as you remember. If your following doze is smaller than 2 hours away, skip the missed doze and use the medication at your following regularly scheduled time.

• If you are using the extended-release tablet and your following doze is smaller than 6 hours away, skip the missed doze and use the medication at your following regularly scheduled time.

• Do not use extra medication to create up a missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medication. An overdose of isosorbide dinitrate can be fatal.

• Overdose symptoms may include a severe throbbing headache, fever, confusion, dizziness or spinning sensation, quick or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cool or clammy skin, feeling light-headed, fainting, and seizure (convulsions).

What must I avoid while taking isosorbide dinitrate?

• Isosorbide dinitrate can reason side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

• Avoid drinking alcohol. It can magnify some of the side effects of isosorbide dinitrate.

What are the possible side effects of isosorbide dinitrate?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· quick, slow, pounding, or uneven heart rate;

· worsening angina pain;

· blurred vision or dry mouth;

· nausea, vomiting, sweating, pale skin, feeling like you might pass out; or

· blue-colored skin, tiredness, and feeling short of breath.

• Smaller serious side effects may be more likely to occur, such as:

· headache, mild dizziness;

· weakness; or

· warmth, redness, or tingly feeling under your skin.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect isosorbide dinitrate?

• Speak your doctor about all another medications you use, especially:

· blood pressure medication;

· dihydroergotamine (D.H.E. 45, Migranal) or ergotamine (Ergomar, Cafergot, and others);

· an erectile dysfunction medicine such as tadalafil (Cialis) or vardenafil (Levitra);

· a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others; or

· a calcium channel blocker such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others.

• This list is not complete and there may be another drugs that can interact with isosorbide dinitrate. Speak your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about isosorbide dinitrate.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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