(dye HYE droe er GOT a meen) Brand: D.H.E. 45
• This medicine can harm an unborn child or a nursing child. Do not use if you are pregnant or breast-feeding.
• Using determined medications together with dihydroergotamine can reason even greater decreases in blood flow than dihydroergotamine used alone, which can lead to dangerous side effects. Tell your doctor about all another medications you are using.
• Also speak your doctor about all of your medical conditions, especially breathing problems, tall blood pressure, ischemic bowel malady, liver or kidney malady, or risk factors for heart disease.
• Never use more than your predesigned doze of dihydroergotamine. An overdose can be fatal.
• Dihydroergotamine is in a group of drugs called ergot alkaloids (ER-got AL-ka-loids). It works by narrowing the blood vessels near the brain and affects blood flow patterns that are associated with determined types of headaches.
• Dihydroergotamine injection is used to treat a migraine or cluster headache onslaught. This medicine will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
• Dihydroergotamine injection must not be used to treat general tension headaches or any headache that seems to be various from your normal migraine headaches. Dihydroergotamine is not for daily use.
• Dihydroergotamine injection may also be used for purposes not listed in this medicine guide.
• Do not use this medicine if you are allergic to dihydroergotamine or another ergot medication such as Ergomar, Cafergot, Migergot, Migranal, or Methergine. Do not use dihydroergotamine injection if you are pregnant or breast-feeding, or if you have:
· a history of heart malady, angina (chest pain), blood circulation problems, or history of a heart onslaught or stroke;
· coronary artery malady or "hardening of the arteries";
· uncontrolled tall blood pressure;
· severe liver or kidney disease;
· a serious infection called sepsis; or
· if you have recently had heart or blood vessel surgery (such as bypass surgery).
• Using determined medications together with dihydroergotamine can reason even greater decreases in blood flow than dihydroergotamine used alone, which can lead to dangerous side effects. Do not use dihydroergotamine if you are also using any of the next medications:
· conivaptan (Vaprisol), imatinib (Gleevec), isoniazid (for treating tuberculosis), or nefazodone (an antidepressant);
· diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);
· clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);
· clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);
· heart or blood pressure medicine such as diltiazem (Cardizem, Dilacor, Tiazac), nicardipine (Cardene), quinidine (Quin-G), or verapamil (Calan, Covera, Isoptin, Verelan); or
· HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase, Fortovase), or ritonavir (Norvir).
• Dihydroergotamine can reason rare but serious side effects on the heart, including heart onslaught or stroke. To create certain you can safely take dihdroergotamine, speak your doctor if you have any of these another conditions:
· breathing problems;
· tall blood pressure;
· ischemic bowel disease;
· liver or kidney malady; or
· coronary heart malady (or risk factors that include diabetes, menopause, smoking, being overweight, having tall blood pressure or tall cholesterol, having a family history of coronary artery malady, being older than 40 and a man, or being a woman who has had a hysterectomy).
• FDA pregnancy category X. Dihydroergotamine can reason birth defects. Do not use if you are pregnant. Speak your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.
• Dihydroergotamine can pass into breast milk and may harm a nursing child. Dihydroergotamine may also decrease milk manufacture. Do not use if you are breast-feeding a baby.
• Use exactly as predesigned by your doctor. Never use more than your predesigned doze of dihydroergotamine. Speak your doctor if the medication seems to stop working as well in treating your migraine attacks.
• Dihydroergotamine is injected into a muscle. You may be shown how to use injections at house. Do not self-inject this medication if you do not fully understand how to give the injection and properly dispose of used needles and syringes.
• Use dihydroergotamine injection as soon as you announcement headache symptoms, or after an onslaught has already begun.
• If your headache does not completely go away, you may use a second injection after 1 hour has passed, and a third injection if needed after other hour has passed (a total of 3 injections).
• If you still have migraine symptoms after using 3 injections, call your doctor till using any more. If your headache goes away and then comes back, you may use the medicine again if it has been at least 6 hours since your recent injection.
• Do not use more than a total of 3 injections of this medicine in any 24-hour period. Do not use more than a total of 6 injections over a period of 7 days.
• Dihydroergotamine injection must be clear and colorless. Do not use if the liquid has changed colors or has particles in it. Call your doctor for a new prescription.
• If you use dihydroergotamine long-term, your doctor may want to check your heart function periodically using an electrocardiograph or ECG (sometimes called an EKG), a car that measures electrical activity of the heart.
• Store at room temperature away from moisture, heat, and easy. Do not use if the expiration date on the label has passed.
• Since dihydroergotamine is used on an as-needed basis, you are not likely to miss a doze. Do not use more than 3 injections of dihydroergotamine for day or more than 6 injections for week.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of dihydroergotamine can be fatal. Overdose symptoms may include some of the serious side effects listed in this medicine guide.
• Do not use dihydroergotamine injection within 24 hours till or after using other migraine headache medicine, including:
· other ergot medication such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (Migranal), or methylergonovine (Methergine); or
· almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), sumatriptan (Imitrex), rizatriptan (Maxalt, Maxalt-MLT), or zolmitriptan (Zomig).
• Grapefruit and grapefruit juice may interact with dihydroergotamine injection and lead to potentially dangerous effects. Discuss the use of grapefruit commodity with your doctor.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Stop using dihydroergotamine and call your doctor at once if you have a serious side effect such as:
· quick or slow heart course, swelling or itching in any part of your body;
· chest pain spreading to the hand or shoulder, and nausea, sweating, or common ill feeling;
· sudden numbness or weakness, sudden headache, confusion, or problems with vision, speech, or balance;
· leg weakness, muscle pain in your arms or legs;
· numbness, tingling, and a pale or blue-colored appearance in your fingers or toes;
· stomach cramps, diarrhea that may be bloody;
· cough with stabbing chest pain and trouble breathing; or
· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath).
• Smaller serious side effects may include:
· headache, dizziness, feeling anxious;
· diarrhea;
· sweating, mild skin rash, redness or tingly feeling under your skin.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Much drugs can interact with dihydroergotamine. Adown is just a partial list. Speak your doctor if you are using:
· zileuton (Zyflo);
· nicotine (Nicoderm, Nicorette);
· cool or allergy medications, diet pills, stimulants, or medicine to treat ADHD (such as Ritalin or Adderall);
· an antidepressant such fluoxetine (Prozac), sertraline (Zoloft), and others;
· fluconazole (Diflucan) or another antifungal medicine; or
· heart or blood pressure medicine such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others.
• This list is not complete and another drugs may interact with dihydroergotamine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your pharmacist can provide more information about dihydroergotamine injection.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.