NISOLDIPINE

(nye ZOL di peen) Brand: Sular

What is the most significant information I must know about nisoldipine?

• You must not use this medicine if you are allergic to nisoldipine, or to similar medications such as amlodipine (Norvasc), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), or nimodipine (Nimotop).

• Till using nisoldipine, speak your doctor if you are allergic to any drugs, or if you have coronary artery malady, congestive heart failure, or liver disease.

• Take nisoldipine on an empty stomach, at least 1 hour till or 2 hours after a meal. Avoid eating grapefruit or drinking grapefruit juice when you take nisoldipine.

• Call your doctor at once if you have a serious side effect such as swelling in your legs or ankles, chest pain, quick or pounding heartbeats, or if you feel like you might pass out.

• Hold using this medication as directed, even if you feel well. Tall blood pressure often has no symptoms, so you may not know when your blood pressure is tall. You may need to use blood pressure medicine for the rest of your life.

• There are much another medicines that can interact with nisoldipine. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor. Hold a list with you of all the medicines you use and show this list to any doctor or another healthcare provider who treats you.

What is nisoldipine?

• Nisoldipine is in a group of drugs called calcium channel blockers. Nisoldipine relaxes (widens) blood vessels and improves blood flow.

• Nisoldipine is used to treat tall blood pressure (hypertension).

• Nisoldipine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking nisoldipine?

• To create certain you can safely take nisoldipine, speak your doctor if you have another medical conditions, especially:

· coronary artery disease;

· congestive heart failure; or

· liver disease.

• FDA pregnancy category C. It is not known whether nisoldipine is deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known if nisoldipine passes into breast milk or if it could harm a nursing infant. Do not take nisoldipine without telling your doctor if you are breast-feeding a baby.

How must I take nisoldipine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Take nisoldipine on an empty stomach, at least 1 hour till or 2 hours after a meal.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow the pill intact. Breaking the pill may reason too many of the drug to be released at one time.

• Your blood pressure will need to be checked often. Visit your doctor regularly.

• Hold using this medication as directed, even if you feel well. Tall blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while taking nisoldipine?

• Grapefruit and grapefruit juice may interact with nisoldipine and lead to unwanted side effects. Discuss the use of grapefruit commodity with your doctor.

What are the possible side effects of nisoldipine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· swelling in your legs or ankles;

· chest pain;

· quick or pounding heartbeats; or

· feeling like you might pass out.

• Smaller serious side effects may include:

· dizziness;

· warmth, redness, or tingly feeling under your skin;

· headache;

· nausea;

· stuffy nose, sore throat; or

· mild skin rash.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect nisoldipine?

• Speak your doctor about all another medications you use, especially:

· another blood pressure medications;

· armodafinil (Nuvigil) or modafinil (Progivil);

· cimetidine (Tagamet);

· conivaptan (Vaprisol);

· dexamethasone (Cortastat, Dexasone, Solurex, DexPak);

· St. John's wort;

· an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), griseofulvin (Fulvicin, Grifulvin, Grisactin), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);

· an antifungal medicine such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);

· an antidepressant such as nefazodone, paroxetine (Paxil), or sertraline (Zoloft);

· a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

· HIV medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), or saquinavir (Invirase); or

· seizure medicine such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline);

• This list is not complete and another drugs may interact with nisoldipine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about nisoldipine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(40)