(PAK li TAK sel) Brand: Onxol
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; feeling like you might pass out; swelling of your person, lips, tongue, or throat.
• Paclitaxel can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
• Paclitaxel is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
• Paclitaxel is used to treat breast cancer, ovarian cancer, and lung cancer. It is also used to treat AIDS-related Kaposi's sarcoma.
• Paclitaxel may also be used for purposes not listed in this medicine guide.
• You must not receive this medicine if you are allergic to paclitaxel, or to another medications that contain an ingredient called Cremophor EL (polyoxyethylated castor oil). This includes cyclosporine and teniposide.
• To create certain paclitaxel is safety for you, speak your doctor if you have:
· HIV, AIDS, or Kaposi's sarcoma;
· heart malady;
· tall blood pressure; or
· liver disease.
• FDA pregnancy category D. Do not receive paclitaxel if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.
• It is not known whether paclitaxel passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using paclitaxel.
• Paclitaxel is injected into a vein through an IV. A healthcare provider will give you this injection. You may be given another medications to prevent an allergic reaction while you are receiving paclitaxel.
• Paclitaxel is generally given once each 3 weeks. Follow your doctor's dosing instructions very carefully.
• Your breathing, blood pressure, oxygen levels, kidney function, and another vital signs will be watched closely while you are receiving paclitaxel.
• Speak your caregivers if you feel any burning, pain, or swelling near the IV needle when paclitaxel is injected.
• Paclitaxel can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
• Call your doctor for instructions if you miss an appointment for your paclitaxel injection.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Drinking alcohol can magnify determined side effects of paclitaxel.
• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.
• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
• Avoid being around people who are sick or have infections. Speak your doctor at once if you develop signs of infection.
• Avoid activities that may magnify your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
• Do not receive a "live" vaccine while using paclitaxel. The vaccine may not work as well during this time, and may not fully protect you from malady. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; feeling like you might pass out; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have:
· fever, chills, body aches, flu symptoms, sores in your mouth and throat;
· pale skin, feeling light-headed or short of breath, rapid heart course, trouble concentrating;
· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
· flushing (warmth, redness, or tingly feeling);
· slow heart course, feeling like you might pass out;
· seizure (convulsions);
· chest pain, dry cough, wheezing, feeling short of breath;
· numbness, tingling, or burning pain in your hands or feet;
· jaundice (yellowing of the skin or eyes); or
· severe redness or swelling, severe irritation, a heavy lump, or skin changes where the injection was given.
• General side effects may include:
· mild nausea, vomiting, diarrhea, constipation;
· weakness;
· joint or muscle pain;
· darkening of your skin or nails; or
· temporary hair loss.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Much drugs can interact with paclitaxel. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with paclitaxel, especially:
· bosentan;
· cyclosporine;
· imatinib;
· nefazodone;
· St. John's wort;
· an antibiotic--clarithromycin, nafcillin, rifabutin, rifampin, rifapentine, telithromycin;
· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
· heart medication--nicardipine, quinidine;
· hepatitis C medications--boceprevir, telaprevir;
· HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir; or
· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone.
• This list is not complete and much another drugs can interact with paclitaxel. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.
• Your doctor or pharmacist can provide more information about paclitaxel.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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