(bor TEZ oh mib) Brand: Velcade
• Bortezomib may reason a serious viral infection of the brain that can lead to disability or death. Call your doctor right away if you have any change in your mental state, decreased vision, or problems with speech or walking. These symptoms may start gradually and get worse quickly.
• Bortezomib can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
• Bortezomib interferes with the growth of some cancer cells and keeps them from spreading in your body.
• Bortezomib is used to treat multiple myeloma and mantle cell lymphoma.
• Bortezomib is sometimes given after another cancer medications have been tried without successful treatment.
• Bortezomib may also be used for purposes not listed in this medicine guide.
• You must not use this medicine if you are allergic to bortezomib, mannitol, or boron.
• To create certain bortezomib is safety for you, speak your doctor if you have:
· diabetes;
· liver disease;
· kidney malady, or if you are on dialysis;
· a bleeding or blood clotting disorder;
· a low level of platelets or white or red blood cells;
· heart malady, congestive heart failure;
· herpes or a history of shingles;
· tall or low blood pressure; or
· nerve problems such as numbness, burning, pain, or tingly feeling.
• FDA pregnancy category D. Do not use bortezomib if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.
• It is not known whether bortezomib passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using bortezomib. Ask your doctor how long to wait till breast-feeding again.
• Bortezomib is injected into a vein through an IV.
• You will receive this injection in a clinic or hospital setting. A doctor, nurse, or another healthcare provider will give you this injection.
• Bortezomib can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
• Call your doctor for instructions if you will miss an appointment for your bortezomib injection.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Avoid being around people who are sick or have infections. Speak your doctor at once if you develop signs of infection.
• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.
• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
• This medicine may reason blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
• Avoid becoming dehydrated if you have any vomiting or diarrhea. Symptoms of dehydration include dizziness, dry mouth, fainting, or hot and dry skin. Conversation with your doctor about how excellent to hold yourself hydrated.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Bortezomib may reason a serious viral infection of the brain that can lead to disability or death. Call your doctor right away if you have any change in your mental state, decreased vision, or problems with speech or walking. These symptoms may start gradually and get worse quickly.
• Also call your doctor at once if you have:
· new or worsening nerve problems such as numbness, burning, pain, weakness, or tingly feeling;
· a light-headed feeling, like you might pass out;
· chest pain, dry cough, swelling in your hands or ankles, feeling short of breath, even with mild exertion;
· severe headache, confusion, and/or seizure (convulsions);
· severe constipation, bloody or tarry stools, vomit that looks like blood or coffee grounds;
· fever, chills, body aches, flu symptoms, light bruising, unusual bleeding (nose, mouth, vagina, or rectum);
· red bumps, spreading skin rash, painful skin lesions on your arms, person, or neck;
· quick or slow heart course, weak pulse, lower back pain, blood in your urine, few or no urinating;
· muscle weakness, tightness, or contraction, overactive reflexes; or
· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
• General side effects may include:
· upset stomach, vomiting;
· diarrhea, constipation, bloating;
· headache, mild dizziness;
· mild rash or itching; or
· feeling tired.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Much drugs can interact with bortezomib. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with bortezomib, especially:
· rifabutin, rifampin, rifapentine;
· St. John's wort;
· an antibiotic--clarithromycin, erythromycin, telithromycin;
· an antifungal medication--clotrimazole, itraconazole, ketoconazole, voriconazole;
· an antidepressant--nefazodone, paroxetine, sertraline;
· a barbiturate--amobarbital, butabarbital, mephobarbital, secobarbital, phenobarbital;
· diabetes medication you take by mouth (your doze may need to be adjusted when your bortezomib treatment starts);
· HIV/AIDS medicine--atazanavir, delavirdine, efavirenz, etravirine, indinavir, nelfinavir, nevirapine, saquinavir, ritonavir;
· medicines to treat narcolepsy--armodafinil, modafinil; or
· seizure medicine--carbamazepine, felbamate, oxcarbazepine, phenytoin, primidone.
• This list is not complete and much another drugs can interact with bortezomib. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.
• Your pharmacist can provide more information about bortezomib.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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