(eye FOS fah mide) Brand: Ifex
• You must not receive ifosfamide if you have a medical condition that causes urination problems (such as an enlarged prostate).
• Serious and sometimes fatal infections may occur during treatment with ifosfamide. Stop using this medication and call your doctor right away if you have signs of infection such as: sudden weakness or ill feeling, fever, chills, cool or flu symptoms, mouth sores, red or swollen gums, trouble swallowing, cough, trouble breathing, pale skin, light bruising, unusual bleeding, or feeling light-headed.
• Ifosfamide can harm your kidneys. Call your doctor at once if you have swelling, pain in your side or lower back, few or no urinating, pain or burning when you urinate, or blood in your urine.
• Ifosfamide can also affect your nervous system. Call your doctor if you have problems with your hearing or vision, ringing in your ears, confusion, unusual thoughts or behavior, hallucinations, or seizure (convulsions).
• Ifosfamide is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
• Ifosfamide is used with another cancer medicines to treat testicular cancer.
• Ifosfamide may also be used for purposes not listed in this medicine guide.
• You must not use ifosfamide if you are allergic to it, or if you have a medical condition that causes urination problems (such as an enlarged prostate).
• To create certain ifosfamide is safety for you, speak your doctor if you have:
· kidney disease;
· a last or active bladder infection;
· if you have ever been treated with busulfan; or
· if your bladder has ever been treated with radiation treatment.
• Using ifosfamide may magnify your risk of developing another types of cancer, such as leukemia. Ask your doctor about your specific risk.
• FDA pregnancy category D. Although ifosfamide is not for use by women, this medicine can reason birth defects if a woman is exposed to it during pregnancy.
• Use effective birth control to prevent pregnancy, whether you are a man or a woman. Ifosfamide use by either parent may reason birth defects. Hold using birth control for at least 6 months after treatment.
• This medicine may affect fertility (your capacity to have children), whether you are a man or a woman. Some women using ifosfamide have stopped having periods, or started having symptoms of early menopause.
• Ifosfamide can pass into breast milk and may harm a nursing child. Do not breast-feed while taking ifosfamide.
• Your doctor will perform blood and urine trials to create certain you do not have conditions that would prevent you from safely using this medicine.
• Ifosfamide is injected into a vein through an IV. A healthcare provider will give you this injection.
• If this medication accidentally gets on your skin, wash it thoroughly with soap and warm water.
• Ifosfamide is given in a 21-day treatment cycle, but you will only need to take the medication during the first 5 days of every cycle. Your doctor will determine how long to treat you with ifosfamide.
• Drink plenty of liquids while you are taking ifosfamide.
• Ifosfamide can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your heart, kidney function, liver function, or nerve and muscle function may also need to be checked. Your cancer treatments may be delayed based on the results of these tests.
• Ifosfamide can have long lasting effects on your body. You may need frequent medical trials for a short time after you stop using this medicine.
• Call your doctor for instructions if you miss a doze of ifosfamide.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Ifosfamide may impair your thinking or reactions. Avoid driving or operating machinery before you know how this medication will affect you.
• Grapefruit and grapefruit juice may interact with ifosfamide and lead to unwanted side effects. Discuss the use of grapefruit commodity with your doctor.
• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.
• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
• Avoid being around people who are sick or have infections. Speak your doctor at once if you develop signs of infection.
• Do not receive a "live" vaccine while using ifosfamide, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
• Drinking alcohol can magnify determined side effects of ifosfamide, especially nausea and vomiting.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Serious and sometimes fatal infections may occur during treatment with ifosfamide. Stop using this medication and call your doctor right away if you have signs of infection such as:
· sudden weakness or ill feeling, fever, chills, sore throat, cool or flu symptoms;
· painful mouth sores, pain when swallowing, red or swollen gums;
· pale skin, light bruising, unusual bleeding (nose, mouth, vagina, or rectum); or
· feeling light-headed or short of breath, chest discomfort, wheezing, dry cough or hack, rapid weight loss.
• Call your doctor at once if you have any of these side effects:
· swelling, pain in your side or lower back, few or no urinating, pain or burning when you urinate, blood in your urine;
· upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
· rapid weight gain, especially in your person and midsection;
· problems with your hearing or vision, ringing in your ears;
· confusion, unusual thoughts or behavior, hallucinations, seizure (convulsions);
· muscle movements you can't control;
· a wound that will not heal; or
· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.
• General side effects may include:
· nausea and vomiting;
· numbness or tingling in your hands or feet;
· drowsiness, dizziness, spinning sensation;
· blurred vision, eye irritation; or
· temporary hair loss.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Using ifosfamide with another drugs that create you sleepy or slow your breathing can reason serious or life-threatening side effects. Ask your doctor till taking a sleeping pill, narcotic pain medication, muscle relaxer, or medication for anxiety, depression, or seizures.
• Much drugs can interact with ifosfamide. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with ifosfamide, especially:
· bosentan;
· imatinib;
· isoniazid;
· nefazodone;
· sorafenib;
· St. John's wort;
· an antibiotic--clarithromycin, telithromycin;
· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;
· heart medication--nicardipine, quinidine;
· hepatitis C medications--boceprevir, telaprevir;
· HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;
· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or
· tuberculosis medication--rifabutin, rifampin, rifapentine.
• This list is not complete and much another drugs can interact with ifosfamide. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.
• Your doctor or pharmacist can provide more information about ifosfamide.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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