SOLIFENACIN

(sol ee FEN a sin) Brand: VESIcare

What is the most significant information I must know about solifenacin?

• You must not use this medicine if you are allergic to solifenacin, or if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate.

• Till using solifenacin, speak your doctor if you have glaucoma, liver malady, kidney malady, a blockage in your stomach or intestines, or a history of Long QT syndrome.

• Avoid becoming overheated or dehydrated during exercice and in hot weather. Solifenacin can decrease perspiration and you may be more prone to heat stroke.

• This medicine may reason blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

• There are much another medicines that can interact with solifenacin. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor. Hold a list of all your medicines and show it to any healthcare provider who treats you.

• Stop using this medicine and call your doctor if you have serious side effects such as hot and dry skin, extreme thirst, severe stomach pain or constipation, pain or burning when you urinate, or if you stop urinating.

What is solifenacin?

• Solifenacin reduces muscle spasms of the bladder and urinary tract.

• Solifenacin is used to treat symptoms of overactive bladder, such as frequent or urgent urination, and incontinence (urine leakage).

• Solifenacin may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking solifenacin?

• You must not use this medicine if you are allergic to solifenacin, or have determined conditions. Be certain your doctor knows if you have:

· untreated or uncontrolled narrow-angle glaucoma;

· a stomach mess causing delayed emptying; or

· if you are unable to urinate.

• To create certain you can safely take solifenacin, speak your doctor if you have any of these another conditions:

· glaucoma;

· liver disease;

· kidney disease;

· a blockage in your stomach or intestines; or

· a history of Long QT syndrome.

• FDA pregnancy category C. It is not known whether solifenacin will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether solifenacin passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using solifenacin.

How must I take solifenacin?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Solifenacin is generally taken once for day. Follow your doctor's instructions.

• Take this medication with water.

• Do not crush, chew, or interrupt the tablet. Swallow it intact.

• Solifenacin can be taken with or without food.

• Store at room temperature away from moisture and heat. Hold the bottle tightly closed when not in use.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while taking solifenacin?

• Avoid becoming overheated or dehydrated during exercice and in hot weather. Solifenacin can decrease perspiration and you may be more prone to heat stroke.

• This medicine may reason blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

What are the possible side effects of solifenacin?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using solifenacin and call your doctor at once if you have a serious side effect such as:

· hot, dry skin and extreme thirst;

· severe stomach pain, or constipation for 3 days or longer;

· pain or burning when you urinate;

· vision changes, eye pain, or seeing halos near lights;

· urinating smaller than normal or not at all;

· confusion, hallucinations;

· tall potassium (slow heart course, weak pulse, muscle weakness, tingly feeling); or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• Smaller serious side effects may include:

· headache, dizziness, drowsiness, feeling tired;

· dry mouth, hoarse voice;

· dry eyes, blurred vision;

· nausea, loss of appetite, upset stomach, heartburn;

· mild constipation; or

· fever, sore throat, body aches, or another flu symptoms.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect solifenacin?

• Speak your doctor about all another medicines you use, especially:

· arsenic trioxide (Trisenox);

· carbamazepine (Carbatrol, Equetro, Tegretol);

· conivaptan (Vaprisol);

· nefazodone;

· phenytoin (Dilantin);

· tacrolimus (Prograf);

· vandetanib (Caprelsa);

· antifungal medicine such as itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), or voriconazole (Vfend);

· the hepatitis C medications boceprevir (Victrelis) or telaprevir (Incivek);

· HIV/AIDS medication such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), or saquinavir (Invirase);

· an antibiotic such as azithromycin (Zithromax, Zmax, Z-Pack), clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam), rifampin (Rifadin, Rifater, Rifamate), or telithromycin (Ketek);

· an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), citalopram (Celexa), clomipramine (Anafranil), or desipramine (Norpramin);

· anti-malaria medications such as chloroquine (Aralen), halofantrine (Halfan), or mefloquine (Lariam);

· heart rhythm medication such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), flecainide (Tambocor), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);

· medication to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron (Zofran);

· medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);

· migraine headache medication such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig); or

· narcotic medicine such as methadone (Methadose, Diskets, Dolophine).

• This list is not complete and another drugs may interact with solifenacin. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about solifenacin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.