DESVENLAFAXINE

(des VEN la FAX een) Brand: Pristiq

What is the most significant information I must know about desvenlafaxine?

• You must not use this medication if you are being treated with methylene blue injection.

• Do not use desvenlafaxine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

• Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using desvenlafaxine. Your family or another caregivers must also be alert to changes in your mood or symptoms.

• Do not give this medicine to anyone under 18 years old without the advice of a doctor.

What is desvenlafaxine?

• Desvenlafaxine is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). Desvenlafaxine affects chemicals in the brain that may become unbalanced and reason depression.

• Desvenlafaxine is used to treat major depressive disorder.

• Desvenlafaxine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking desvenlafaxine?

• You must not use this medication if you are allergic to desvenlafaxine or venlafaxine (Effexor), or if you are being treated with methylene blue injection.

• Do not use desvenlafaxine if you are taking an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. You should wait at least 14 days after stopping an MAOI till you can take desvenlafaxine. After you stop taking desvenlafaxine, you should wait at least 7 days till you start taking an MAOI.

• To create certain desvenlafaxine is safety for you, speak your doctor if you have:

· bipolar mess (manic depression);

· liver or kidney disease;

· heart malady, tall blood pressure, tall cholesterol, or a history of stroke;

· glaucoma;

· seizures or epilepsy;

· a history of stroke;

· a bleeding or blood clotting mess;

· low levels of sodium in your blood; or

· if you are switching to desvenlafaxine from other antidepressant.

• FDA pregnancy category C. Desvenlafaxine may reason problems in a newborn child if the mother takes the medicine late in pregnancy (during the third trimester). Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• Desvenlafaxine can pass into breast milk and may harm a nursing child. Speak your doctor if you are breast-feeding a baby.

• Do not give this medicine to anyone under 18 years old without the advice of a doctor.

How must I take desvenlafaxine?

• Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• You may take desvenlafaxine with or without food. Take the medication at the same time every day.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact.

• It may take different weeks till your symptoms improve. Hold using the medicine as directed and speak your doctor if your symptoms do not improve.

• Do not stop using desvenlafaxine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using desvenlafaxine.

• Your blood pressure will need to be checked often.

• This medicine can reason you to have a false positive drug screening test. If you provide a urine sample for drug screening, speak the laboratory staff that you are taking desvenlafaxine.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking desvenlafaxine?

• Drinking alcohol can magnify determined side effects of desvenlafaxine.

• Ask your doctor till taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with desvenlafaxine may reason you to bruise or bleed easily.

• Desvenlafaxine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Avoid exposure to sunlight or tanning beds. Desvenlafaxine can create you sunburn more easily. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.

What are the possible side effects of desvenlafaxine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

• Call your doctor at once if you have:

· seizure (convulsions);

· agitation, hallucinations, fever, quick heart course, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination;

· blurred vision, eye pain, or seeing halos near lights;

· cough, chest tightness, trouble breathing;

· light bruising or bleeding (nosebleeds, bleeding gums), blood in your urine or stools, coughing up blood;

· very stiff (rigid) muscles, tall fever, sweating, confusion, quick or uneven heartbeats, tremors, feeling like you might pass out;

· headache, slurred speech, severe weakness, muscle cramps, feeling unsteady, fainting, shallow breathing (breathing may stop);

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• General side effects may include:

· dizziness, drowsiness, anxiety;

· heighten sweating;

· mild nausea, loss of appetite, constipation;

· sleep problems (insomnia); or

· decreased sex drive, impotence, or difficulty having an orgasm.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect desvenlafaxine?

• Taking desvenlafaxine with another drugs that create you sleepy or slow your breathing can magnify these effects. Ask your doctor till taking desvenlafaxine with a sleeping pill, narcotic pain medication, muscle relaxer, or medication for anxiety or seizures.

• Much drugs can interact with desvenlafaxine. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with desvenlafaxine, especially:

· any another antidepressant;

· a blood thinner such as warfarin, Coumadin;

· a diuretic or "water pill";

· lithium;

· midazolam;

· imatinib;

· St. John's wort;

· tryptophan (sometimes called L-tryptophan);

· an antibiotic--clarithromycin, telithromycin;

· antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

· heart medication--nicardipine, quinidine;

· hepatitis C medications--boceprevir, telaprevir;

· HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir;

· migraine headache medication--sumatriptan, rizatriptan, and others; or

· pain medication--fentanyl or tramadol.

• This list is not complete and much another drugs can interact with desvenlafaxine. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about desvenlafaxine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(31)