RIZATRIPTAN

(RYE za TRIP tan) Brand: Maxalt, Maxalt-MLT

What is the most significant information I must know about rizatriptan?

• You must not take this medicine if you are allergic to rizatriptan, if you have any history of heart malady, or if you have coronary heart malady, angina, blood circulation problems, lack of blood supply to the heart, uncontrolled tall blood pressure, ischemic bowel malady, a history of a heart onslaught or stroke, or if your headache seems to be various from your normal migraine headaches.

• Do not take rizatriptan within 24 hours till or after using other migraine headache medicine, including almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), sumatriptan (Imitrex, Treximet), zolmitriptan (Zomig), or ergot medication such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine).

• Do not use rizatriptan if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the past 14 days.

• Till taking rizatriptan, speak your doctor if you have liver or kidney malady, tall blood pressure, a heart rhythm mess, or coronary heart malady (or risk factors such as diabetes, menopause, smoking, being overweight, having tall cholesterol, having a family history of coronary artery malady, being older than 40 and a man, or being a woman who has had a hysterectomy).

• Also speak your doctor if you are also taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), sertraline (Zoloft), trazodone (Desyrel, Oleptro), venlafaxine (Effexor), or vilazodone (Viibryd).

• Rizatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

• After taking a rizatriptan tablet, you should wait two (2) hours till taking a second tablet. Do not take more than 30 mg of rizatriptan in 24 hours.

What is rizatriptan?

• Rizatriptan is a headache medication that narrows the blood vessels near the brain. Rizatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to easy and sound, and another migraine symptoms.

• Rizatriptan is used to treat migraine headaches. Rizatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

• Rizatriptan must not be used to treat a general tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be various from your normal migraine headaches. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches.

• Rizatriptan may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till using rizatriptan?

• You must not take this medicine if you are allergic to rizatriptan, or if you have:

· coronary heart malady, angina (chest pain), blood circulation problems, lack of blood supply to the heart;

· a history of heart malady, heart onslaught, or stroke, including "mini-stroke";

· severe or uncontrolled tall blood pressure;

· ischemic bowel malady; or

· a headache that seems various from your normal migraine headaches.

• Do not take rizatriptan if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the past 14 days.

• To create certain you can safely take rizatriptan, speak your doctor if you have any of these another conditions:

· liver disease;

· kidney malady (especially if you are on dialysis);

· tall blood pressure, a heart rhythm mess; or

· coronary heart malady (or risk factors such as diabetes, menopause, smoking, being overweight, having tall cholesterol, having a family history of coronary artery malady, being older than 40 and a man, or being a woman who has had a hysterectomy).

• Rizatriptan disintegrating tablets may contain phenylalanine. Conversation to your doctor till using this form of rizatriptan if you have phenylketonuria (PKU).

• FDA pregnancy category C. It is not known whether rizatriptan will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether rizatriptan passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Do not give a rizatriptan regular tablet to anyone under 18 years old. Only rizatriptan orally disintegrating tablets (Maxalt-MLT) are for use in children who are at least 6 years old.

How must I use rizatriptan?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Overuse of migraine headache medication can actually create your headaches worse.

• Take rizatriptan as soon as you announcement headache symptoms, or after an onslaught has already begun.

• Your doctor may want to give your first doze of this medication in a hospital or clinic setting to see if you have any serious side effects.

• Take one rizatriptan tablet intact with a full glass of water.

• To take rizatriptan orally disintegrating tablets (Maxalt-MLT):

· Hold the tablet in its blister pack before you are ready to take the medication. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may hurt the tablet.

· Using dry hands, remove the tablet and seat it in your mouth. It will begin to dissolve right away.

· Do not swallow the tablet intact. Let it to dissolve in your mouth without chewing.

· Swallow different times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

• After taking a tablet: If your headache does not completely go away, or goes away and comes back, take a second tablet two (2) hours after the first. Do not take more than 30 mg of rizatriptan in 24 hours. If your symptoms have not ameliorate, contact your doctor till taking any more tablets.

• Contact your doctor if you have more than four headaches in one month (30 days).

• If you use rizatriptan long-term, your doctor may want to check your heart function using an electrocardiograph or ECG (sometimes called an EKG), a car that measures electrical activity of the heart. This will help your doctor determine if it is still safety for you to use this medicine. Visit your doctor regularly.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Since rizatriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using rizatriptan.

• After taking a rizatriptan tablet, you should wait two (2) hours till taking a second tablet. Do not take more than 30 mg of rizatriptan in 24 hours.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose could reason tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, or seizure).

What must I avoid while using rizatriptan?

• Do not take rizatriptan within 24 hours till or after using other migraine headache medication, including:

· almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), sumatriptan (Imitrex, Treximet), or zolmitriptan (Zomig); or

· ergot medication such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine).

• Rizatriptan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of rizatriptan?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using rizatriptan and call your doctor at once if you have a serious side effect such as:

· feeling of pain or tightness in your jaw, neck, or throat;

· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling;

· sudden numbness or weakness, especially on one side of the body;

· sudden severe headache, confusion, problems with vision, speech, or balance;

· sudden and severe stomach pain and bloody diarrhea;

· numbness or tingling and a pale or blue-colored appearance in your fingers or toes; or

· (if you are also taking an antidepressant) -- agitation, hallucinations, fever, quick heart course, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

• Smaller serious side effects may include:

· mild headache (not a migraine);

· dry mouth, mild nausea;

· pressure or hard feeling in any part of your body;

· dizziness, drowsiness, weary feeling; or

· warmth, redness, or mild tingling under your skin.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect rizatriptan?

• Speak your doctor about all another medicines you use, especially:

· propranolol (Inderal, InnoPran); or

· an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), sertraline (Zoloft), trazodone (Desyrel, Oleptro), venlafaxine (Effexor), or vilazodone (Viibryd).

• This list is not complete and another drugs may interact with rizatriptan. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about rizatriptan.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

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