ALPROSTADIL (INJECTABLE AND TRANSURETHRAL)

(al PROS ta dil) Brand: Caverject, Caverject Impulse, Edex, Muse

What is the most significant information I must know about alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose determined causes of this mess. Alprostadil is also used to improve blood flow in newborn babies with a determined genetic heart condition. This alprostadil medicine manual addresses only the adult male use of this medicine in erectile disorders.

• You must not use this medicine if you are allergic to alprostadil, or if you have sickle cell anemia, leukemia, a bone marrow tumor, a curved or deformed penis, penile fibrosis or Peyronie's malady, a penile implant, or if you have been told you must not have sexual intercourse for health reasons.

• Till using alprostadil, speak your doctor if you have heart malady, tall blood pressure, a bleeding mess, a history of blood clots, or a malady that could be passed in blood (such as hepatitis or HIV).

• The injectable form of alprostadil is injected into the side of the penis. The transurethral pellet is a very little suppository that is inserted into the opening of the penis (the urethra).

• Use this medicine exactly as it was predesigned for you. Using too many alprostadil can be very dangerous. The medication comes with patient instructions for safety and effective use. Follow these directions carefully.

• Your first doze of this medication will be given in your doctor's office so you can be observed for how well the medicine works and if it causes any side effects.

• Do not self-inject this medication if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Call your doctor, nurse, or pharmacist if you have any questions. Using an alprostadil transurethral pellet improperly could reason hurt to your urethra.

Alprostadil is used only when needed to get an erection. An erection must occur within 5 to 20 minutes after you use the medicine, and must recent for 30 to 60 minutes.

• Search abnormal medical attention if you have a painful or prolonged erection lasting 4 hours or longer.

What is alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose determined causes of this mess. Alprostadil is also used to improve blood flow in newborn babies with a determined genetic heart condition. This alprostadil medicine manual addresses only the adult male use of this medicine in erectile disorders.

Alprostadil relaxes blood vessels and muscles in the penis. This increases blood flow into the penis, causing an erection.

Alprostadil may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till using alprostadil?

• You must not use this medicine if you are allergic to alprostadil, or if you have:

· sickle cell anemia or the sickle cell anemia trait;

· leukemia;

· a tumor of the bone marrow (multiple myeloma);

· a curved or deformed penis;

· penile fibrosis or Peyronie's malady;

· if you have a penile implant; or

· if you have been told you must not have sexual intercourse for health reasons.

• To create certain you can safely use alprostadil, speak your doctor if you have any of these another conditions:

· a history of blood clots;

· heart malady, tall blood pressure (hypertension);

· a bleeding or blood-clotting mess; or

· a malady that could be passed in blood (such as hepatitis or HIV).

• Use a condom to prevent transfer of this medicine to your sexual partner if she is pregnant or could become pregnant.

Caverject, Caverject Impulse, Edex, or Muse must not be used by women or by anyone under 18 years old.

How must I use alprostadil?

• Your first doze of this medication will be given in your doctor's office so you can be observed for how well the medicine works and if it causes any side effects. You will then be shown how to properly give the medicine to yourself. Wait at least 1 day after your first doze till using the medication again.

• Use exactly as predesigned by your doctor. Do not use in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Using too many alprostadil can be very dangerous.

Alprostadil is used only when needed to get an erection. An erection must occur within 5 to 20 minutes after you use the medicine, and must recent for 30 to 60 minutes. The length of time your erection lasts may be slightly different.

• The injectable form of alprostadil is injected into the side of the penis.

• The transurethral pellet is a very little suppository that is inserted into the opening of the penis (the urethra).

• Do not use more than 2 alprostadil pellets in one day (24 hours). Do not use more than 3 alprostadil injections for week. Let at least 24 hours to pass between injections.

Alprostadil comes with patient instructions for safety and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Alprostadil injectable is a powder medication that comes with a sterile liquid for mixing it. Caverject Impulse is a brand of alprostadil injectable supplied as a needle and syringe that contains both the powder medication and the sterile liquid. The doze is automatically mixed when you turn a dial on the end of the syringe. The Caverject Impulse syringe is designed for only one use. Carefully follow the instructions provided with this product.

• Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Hold this container out of the reach of children and pets.

• Prepare your alprostadil doze only when you are ready to use the medication. Do not shake the mixed medication. After mixing, the medicine must be clear. Do not use the medicine if it looks cloudy or has particles in it. Call your doctor for a new prescription.

• Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an alprostadil transurethral pellet improperly could reason hurt to your urethra.

• The Caverject Impulse device uses a very thin needle, which could interrupt easily. If the needle breaks during injection and you can see and grasp the broken end, remove it and contact your doctor. If you can't remove the broken end, call your doctor right away.

• An alprostadil injection can reason bleeding where the needle is placed. This can create it easier for your sexual partner to be exposed to your blood. Till using this medicine, speak your doctor if you have a virus such as hepatitis or HIV, which can be passed to other face who comes into contact with your blood.

• To be certain this medicine is not causing deleterious effects, your penis may need to be examined each 3 months. Visit your doctor regularly.

Storing this medicine:

· Hold every urethral pellet in its original foil pouch before you are ready to use it. Store the foil pouches in the refrigerator. You may store the pouches at room temperature for up to 14 days.

· Store alprostadil injectable at room temperature. The 40 microgram power of unmixed alprostadil can be stored at room temperature for up to 3 months, or before the expiration date on the label, whichever happens first.

· Do not expose alprostadil commodity to freezing or very hot temperatures. Do not store your medicine in a closed automobile, or pack it into baggage that will be placed into a cargo area during travel.

What happens if I miss a dose?

• Since alprostadil is used as needed, you will not be on a dosing schedule.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include feeling light-headed, fainting, or having a painful or prolonged erection lasting 4 hours or longer.

What must I avoid while using alprostadil?

• This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Taking this medicine will not prevent you from passing a malady such as hepatitis or HIV to your sexual partner. Avoid having unprotected sex. Conversation with your doctor about safety ways to prevent HIV transmission during sex. Sharing drug or medication needles is never safety, even for a healthy person.

What are the possible side effects of alprostadil?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using alprostadil and call your doctor at once if you have a serious side effect such as:

· feeling light-headed, fainting;

· trouble urinating, blood in your urine;

· bleeding, bruising, or swelling where you injected the medication;

· a painful erection that lasts 4 hours or longer;

· severe pain or irritation of your penis or urethra; or

· redness, lumps, tenderness, unusual shape or curving of the erect penis.

• Smaller serious side effects may include:

· unusual discharge from your penis; or

· mild pain in your penis, urethra, or testicles;

· headache, dizziness;

· back pain;

· a rash on the skin of your penis;

· itching, warmth, or numbness of your penis;

· cough, stuffy nose, cool symptoms, flu symptoms.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

• Your sexual partner may also have side effects such as burning, itching, or irritation of the body areas that come into contact with your penis.

What another drugs will affect alprostadil?

• Speak your doctor about all another medicines you use, especially:

· blood pressure medicine; or

· a blood thinner such as heparin or warfarin (Coumadin, Jantoven).

• This list is not complete and another drugs may interact with alprostadil. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about alprostadil.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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